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Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent
Open accessAbstract
Leukocyte migration is a key event both in host defense against invading pathogens as well as in inflammation. Bacteria generate chemoattractants primarily by excretion (formylated peptides), complement activation (C5a), and subsequently through activation of leukocytes (e.g., leukotriene B4, platelet-activating factor, and interleukin 8). Here we describe a new protein secreted by Staphylococcus aureus that specifically impairs the response of neutrophils and monocytes to formylated peptides and C5a. This chemotaxis inhibitory protein of S. aureus (CHIPS) is a 14.1-kD protein encoded on a bacteriophage and is found in >60% of clinical isolates. CHIPS reduces the neutrophil recruitment toward C5a in a mouse peritonitis model, even though its activity is much more potent on human than on mouse cells. These findings suggest a new immune escape mechanism of S. aureus and put forward CHIPS as a potential new antiinflammatory therapeutic compound.
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Citations
Cited by
Complement and its role in innate and adaptive immune responses
Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932
Diep, B. A., Gill, S. R., Chang, R. F., Phan, T. H., Chen, J. H., Davidson, M. G., Lin, F., Lin, J., Carleton, H. A., Mongodin, E. F., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68231-7 · Cited by 1,633
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Food Poisoning and Staphylococcus aureus Enterotoxins
Argudín, M. Á., Mendoza, M. C., & Rodicio, M. R. (2010) · Toxins · doi:10.3390/toxins2071751 · Cited by 1,161
Skin microbiota–host interactions
Chen, Y. E., Fischbach, M. A., & Belkaid, Y. (2018) · Nature · doi:10.1038/nature25177 · Cited by 786
Metadata
- Authors
- de Haas, C. J. C., Veldkamp, K. E., Peschel, A., Weerkamp, F., Van Wamel, W. J. B., Heezius, E. C. J. M., Poppelier, M. J. J. G., Van Kessel, K. P. M., & van Strijp, J. A. G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-03-01
- Volume
- 199
- Issue
- 5
- Pages
- 687-695
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2119768770
- Cited by
- 471
- References
- 0
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Haas, C. J. C., Veldkamp, K. E., Peschel, A., Weerkamp, F., Van Wamel, W. J. B., Heezius, E. C. J. M., Poppelier, M. J. J. G., Van Kessel, K. P. M., & van Strijp, J. A. G. (2004). Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20031636
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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