The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy
Open accessAbstract
Type I interferons (IFNs) are critical mediators of antiviral defense, but their elicitation by bacterial pathogens can be detrimental to hosts. Many intracellular bacterial pathogens, including Mycobacterium tuberculosis, induce type I IFNs following phagosomal membrane perturbations. Cytosolic M. tuberculosis DNA has been implicated as a trigger for IFN production, but the mechanisms remain obscure. We report that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activating IFN production via the STING/TBK1/IRF3 pathway during M. tuberculosis and L. pneumophila infection of macrophages, whereas L. monocytogenes short-circuits this pathway by producing the STING agonist, c-di-AMP. Upon sensing cytosolic DNA, cGAS also activates cell-intrinsic antibacterial defenses, promoting autophagic targeting of M. tuberculosis. Importantly, we show that cGAS binds M. tuberculosis DNA during infection, providing direct evidence that this unique host-pathogen interaction occurs in vivo. These data uncover a mechanism by which IFN is likely elicited during active human infections.
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This phagosome-to-cytosol transition process has consequences for the host cell, such as induction of the cGAS/STING/TBK1/IRF-3/type I interferon signalling axis and NLRP3 inflammasome activation.
“an important cell biological process that has numerous consequences for the host cell, such as induc-tion of the cGAS/STING/TBK1/IRF-3/type I interferon signalling axis and NLRP3 inflammasome activation (69)(70)(71)(72)(73)(74)(75).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [71]
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Cites
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,549 · see citing works
Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252 · see citing works
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898 · see citing works
STING is a direct innate immune sensor of cyclic di-GMP
Burdette, D. L., Monroe, K. M., Sotelo-Troha, K., Iwig, J. S., Eckert, B., Hyodo, M., Hayakawa, Y., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10429 · Cited by 1,570 · see citing works
Self-citationPivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,097 · see citing works
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
Thurston, T. L. M., Wandel, M. P., von Muhlinen, N., Foeglein, Á., & Randow, F. (2012) · Nature · doi:10.1038/nature10744 · Cited by 1,034 · see citing works
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.003 · Cited by 1,003 · see citing works
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1240933 · Cited by 986 · see citing works
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., et al. (2014) · Nature · doi:10.1038/nature12862 · Cited by 896 · see citing works
Self-citationAutophagy, Immunity, and Microbial Adaptations
Deretic, V. P., & Levine, B. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.016 · Cited by 868 · see citing works
Woodward, J. J., Iavarone, A. T., & Portnoy, D. A. (2010) · Science · doi:10.1126/science.1189801 · Cited by 813 · see citing works
Watson, R. O., Manzanillo, P. S., & Cox, J. S. (2012) · Cell · doi:10.1016/j.cell.2012.06.040 · Cited by 755 · see citing works
Self-citationAutophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole
Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509157200 · Cited by 658 · see citing works
Manca, C., Tsenova, L., Bergtold, A., Freeman, S. L., Tovey, M. G., Musser, J. M., Barry, C. E., Freedman, V. H., & Kaplan, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091096998 · Cited by 590 · see citing works
Sauer, J., Troha, K., von Moltke, J., Monroe, K. M., Rae, C. S., Brubaker, S. W., Hyodo, M., Hayakawa, Y., Woodward, J. J., Portnoy, D. A., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00999-10 · Cited by 540 · see citing works
Self-citationVance, R. E., Isberg, R. R., & Portnoy, D. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.06.007 · Cited by 512 · see citing works
Self-citationSTING and the innate immune response to nucleic acids in the cytosol
Burdette, D. L., & Vance, R. E. (2013) · Nature Immunology · doi:10.1038/ni.2491 · Cited by 501 · see citing works
Self-citationType I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection
O’Connell, R. M., Saha, S. K., Vaidya, S. A., Bruhn, K. W., Miranda, G. A., Zarnegar, B. J., Perry, A. K., Nguyen, B. D., Lane, T. F., Taniguchi, T., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040712 · Cited by 489 · see citing works
The <i>Legionella</i> Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation
Choy, A., Dancourt, J., Mugo, B., O’Connor, T. J., Isberg, R. R., Melia, T. J., & Roy, C. R. (2012) · Science · doi:10.1126/science.1227026 · Cited by 473 · see citing works
Manzanillo, P. S., Shiloh, M. U., Portnoy, D. A., & Cox, J. S. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.03.007 · Cited by 456 · see citing works
Self-citationMice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes
Auerbuch, V., Brockstedt, D. G., Meyer-Morse, N., O’Riordan, M. X., & Portnoy, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040976 · Cited by 451 · see citing works
Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.002 · Cited by 418 · see citing works
Zhao, Z., Fux, B., Goodwin, M., Dunay, I. R., Strong, D. W., Miller, B. C., Cadwell, K., Delgado, M. A., Ponpuak, M., Green, K. G., et al. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.003 · Cited by 413 · see citing works
Self-citationWassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.003 · Cited by 401 · see citing works
Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to Listeria Infection
Carrero, J. A., Calderón, B., & Unanue, E. R. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040769 · Cited by 390 · see citing works
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis
Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X.-D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.005 · Cited by 384 · see citing works
Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses
Teles, R. M. B., Graeber, T. G., Krutzik, S. R., Montoya, D. J., Schenk, M., Lee, D. J., Komisopoulou, E., Kelly‐Scumpia, K. M., Chun, R. F., Iyer, S. S., et al. (2013) · Science · doi:10.1126/science.1233665 · Cited by 381 · see citing works
Liang, Q., Seo, G. J., Choi, Y. J., Kwak, M., Ge, J., Rodgers, M. A., Shi, M., Leslie, B. J., Hopfner, K., Ha, T., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.01.009 · Cited by 351 · see citing works
Innate recognition of bacteria by a macrophage cytosolic surveillance pathway
O’Riordan, M. X., Yi, C. H., Gonzales, R., Lee, K., & Portnoy, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202476699 · Cited by 282 · see citing works
Dey, B., Dey, R. J., Cheung, L. S., Pokkali, S., Guo, H., Lee, J., & Bishai, W. R. (2015) · Nature Medicine · doi:10.1038/nm.3813 · Cited by 263 · see citing works
Novikov, A., Cardone, M., Thompson, R. W., Shenderov, K., Kirschman, K. D., Mayer-Barber, K. D., Myers, T. G., Rabin, R. L., Trinchieri, G., Sher, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100926 · Cited by 243 · see citing works
Zughaier, S. M., Zimmer, S. M., Datta, A., Carlson, R. W., & Stephens, D. S. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.2940-2950.2005 · Cited by 240 · see citing works
Lee, J., Remold, H. G., Ieong, M. H., & Kornfeld, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4267 · Cited by 238 · see citing works
Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen
Leber, J. H., Crimmins, G. T., Raghavan, S., Meyer-Morse, N., Cox, J. S., & Portnoy, D. A. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040006 · Cited by 221 · see citing works
Self-citationModulation of Inflammasome Pathways by Bacterial and Viral Pathogens
Lamkanfi, M., & Dixit, V. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100229 · Cited by 217 · see citing works
The protein SdhA maintains the integrity of the Legionella -containing vacuole
Creasey, E. A., & Isberg, R. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121286109 · Cited by 198 · see citing works
Monroe, K. M., McWhirter, S. M., & Vance, R. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000665 · Cited by 190 · see citing works
Self-citationChoi, J., Park, S., Biering, S. B., Selleck, E. M., Liu, C. Y., Zhang, X., Fujita, N., Saitoh, T., Akira, S., Yoshimori, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.006 · Cited by 181 · see citing works
Self-citationZhang, Y., Yeruva, L., Marinov, A. D., Prantner, D., Wyrick, P. B., Lupashin, V. V., & Nagarajan, U. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302718 · Cited by 152 · see citing works
Induction of type I interferons by bacteria
Monroe, K. M., McWhirter, S. M., & Vance, R. E. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01478.x · Cited by 144 · see citing works
Self-citationListeria phospholipases subvert host autophagic defenses by stalling pre‐autophagosomal structures
Tattoli, I., Sorbara, M. T., Yang, C., Tooze, S. A., Philpott, D. J., & Girardin, S. E. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.234 · Cited by 144 · see citing works
Lippmann, J., Rothenburg, S., Deigendesch, N., Eitel, J., Meixenberger, K., van Laak, V., Slevogt, H., N’Guessan, P. D., Hippenstiel, S., Chakraborty, T., et al. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01232.x · Cited by 89 · see citing works
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Self-citationRegulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333 · see citing works
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Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0151-1 · Cited by 1,467 · see citing works
Autophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works
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West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115 · see citing works
Dunphy, G., Flannery, S. M., Almine, J. F., Connolly, D. J., Paulus, C., Jønsson, K. L., Jakobsen, M. R., Nevels, M. M., Bowie, A. G., & Unterholzner, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.034 · Cited by 648 · see citing works
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Deretic, V., & Levine, B. (2018) · Autophagy · doi:10.1080/15548627.2017.1402992 · Cited by 563 · see citing works
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Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, C. C., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., et al. (2017) · Nature · doi:10.1038/nature23890 · Cited by 511 · see citing works
Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.003 · Cited by 401 · see citing works
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Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.131 · Cited by 382 · see citing works
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Boxx, G. M., & Cheng, G. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.016 · Cited by 335 · see citing works
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Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315 · see citing works
“Activated STING is able to recruit TANK-binding kinase 1 (TBK1), which phosphorylates interferon regulatory factor 3 (IRF3) to enhance its homodimerization and migrate into the nucleus, followed by induction of interferon β (IFNβ) and interferon-stimulated genes (ISGs) (Schoggins et al., 2014; Storek et al., 2015; Wat…”
BackgroundLama, L., Adura, C., Xie, W., Tomita, D., Kamei, T., Kuryavyi, V., Gogakos, T., Steinberg, J. I., Miller, M., Ramos-Espiritu, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08620-4 · Cited by 303 · see citing works
Beckwith, K. S., Beckwith, M. S., Ullmann, S., Sætra, R. S., Kim, H., Marstad, A., Åsberg, S. E., Strand, T. A., Haug, M., Niederweis, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16143-6 · Cited by 282 · see citing works
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Queval, C. J., Brosch, R., & Simeone, R. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02284 · Cited by 215 · see citing works
Köster, S., Upadhyay, S., Chandra, P., Papavinasasundaram, K., Yang, G., Hassan, A., Grigsby, S. J., Mittal, E., Park, H. S., Jones, V., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707792114 · Cited by 208 · see citing works
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
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Mitchell*, G., Chen*, C., & Portnoy, D. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0012-2015 · Cited by 137 · see citing works
Gröschel, M. I., Sayes, F., Shin, S. J., Frigui, W., Pawlik, A., Orgeur, M., Canetti, R., Honoré, N., Simeone, R., van der Werf, T. S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.057 · Cited by 125 · see citing works
Mittal, E., Skowyra, M. L., Uwase, G., Tinaztepe, E., Mehra, A., Köster, S., Hanson, P. I., & Philips, J. A. (2018) · mBio · doi:10.1128/mbio.01765-18 · Cited by 110 · see citing works
Patrick, K. L., Bell, S. L., Weindel, C. G., & Watson, R. O. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00138 · Cited by 110 · see citing works
Self-citationBarczak, A. K., Avraham, R., Singh, S., Luo, S. S., Zhang, W. R., Bray, M.-A., Hinman, A. E., Thompson, M., Nietupski, R. M., Golas, A., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006363 · Cited by 120 · see citing works
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Sun, H., Huang, Y., Mei, S., Xu, F., Liu, X., Zhao, F., Yin, L., Zhang, D., Wei, L., Wu, C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108586 · Cited by 105 · see citing works
Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity
Zahid, A., Ismail, H., Li, B., & Jin, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613039 · Cited by 100 · see citing works
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Sala, C., Odermatt, N. T., Soler-Arnedo, P., Gülen, M. F., von Schultz, S., Benjak, A., & Cole, S. T. (2018) · PLOS Pathogens · doi:10.1371/journal.ppat.1007491 · Cited by 35 · see citing works
- Authors
- Watson, R. O., Bell, S. L., MacDuff, D. A., Kimmey, J. M., Diner, E. J., Olivas, J., Vance, R. E., Stallings, C. L., Virgin, H. W., & Cox, J. S.
- Affiliations
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- University of California, Berkeley (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Cox, Jeffery S.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 17
- Issue
- 6
- Pages
- 811-819
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC4466081
- OpenAlex
- W1667606852
- Cited by
- 645
- References
- 44
- Citations by year
- 2026: 50 · 2025: 41 · 2024: 54 · 2023: 53 · 2022: 60 · 2021: 66 · 2020: 67 · 2019: 54 · 2018: 59 · 2017: 70 · 2016: 54 · 2015: 17
- FWCI
- 32.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- Arnold and Mabel Beckman Foundation
- Damon Runyon Cancer Research Foundation
- University of Pennsylvania
- National Institutes of Health
- University of California, San Francisco
- National Institute of General Medical Sciences (GM: 007067, T32GM007067, T32GM008568)
- National Institute of Allergy and Infectious Diseases (U19AI109725, P01AI063302)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- cGAS, Mycobacterium tuberculosis, type I interferon, STING, TBK1, IRF3, autophagy, cytosolic DNA sensing, Listeria monocytogenes, c-di-AMP, macrophages, host-pathogen interaction, intracellular bacterial infection, innate immunity
- MeSH terms
- Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Animals, Antigens, Bacterial, Autophagy, Bacterial Proteins, Cytosol, DNA, Bacterial, Female, Interferon Type I, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Mycobacterium tuberculosis, Nucleotidyltransferases, Tuberculosis, Legionella pneumophila, Host-Pathogen Interactions
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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