DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,264

ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Guermonprez, P., Saveanu, L., Kleijmeer, M. J., Davoust, J. M., Endert, P. V., & Amigorena, S. (2003) · Nature · doi:10.1038/nature01911 · Cited by 753

Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors.

Arai, F., Miyamoto, T., Ohneda, O., Inada, T., Sudo, T., Brasel, K., Miyata, T., Anderson, D. M., & Suda, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1741 · Cited by 693

Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

Matsuo, K., Galson, D. L., Chen, Z., Peng, L., Laplace, C., Wang, K. Z. Q., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313973200 · Cited by 570

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

Boyce, B. F., Yoneda, T., Lowe, C., Soriano, P. M., & Mundy, G. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116032 · Cited by 553

RANKL-induced DC-STAMP Is Essential for Osteoclastogenesis

Kukita, T., Wada, N., Kukita, A., Kakimoto, T., Sandra, F., Toh, K., Nagata, K., Iijima, T., Horiuchi, M., Matsusaki, H., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040518 · Cited by 357

Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells.

(1995) · Europe PMC (PubMed Central) · Cited by 294

Bifurcation of osteoclasts and dendritic cells from common progenitors

Miyamoto, T. K., Ohneda, O., Arai, F., Iwamoto, K., Okada, S., Takagi, K., Anderson, D. M., & Suda, T. (2001) · Blood · doi:10.1182/blood.v98.8.2544 · Cited by 280

Precursors linked via the zipper-like structure or the filopodium during the secondary fusion of osteoclasts

Takito, J., & Nakamura, M. (2012) · Communicative & Integrative Biology · doi:10.4161/cib.20980 · Cited by 17

Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy

Tomlinson, G. S., Thomas, N., Chain, B., Best, K., Simpson, N., Hardavella, G. F., Brown, J., Bhowmik, A., Navani, N., Janes, S. M., et al. (2015) · CHEST Journal · doi:10.1378/chest.15-0647 · Cited by 17

Development of the Skeleton

Provot, S., Schipani, E., Wu, J. Y., & Kronenberg, H. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00006-6 · Cited by 18

Osteoclastic microRNAs and their translational potential in skeletal diseases

Inoue, K., Nakano, S., & Zhao, B. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00761-4 · Cited by 18

Cell Fusion and Hyperactive Osteoclastogenesis in Multiple Myeloma

Silvestris, F., Ciavarella, S., Strippoli, S., & Dammacco, F. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0782-5_5 · Cited by 17

Asperuloside Prevents Peri-Implantitis via Suppression of NF-κB and ERK1/2 on Rats

Wang, X., Chen, X., Zhang, Z., Chen, J., Ge, Z., Huang, S., Wei, H., & Li, D. (2022) · Pharmaceuticals · doi:10.3390/ph15081027 · Cited by 16

Matrix-enabled mechanobiological modulation of osteoimmunology

Lee, J., Park, J. H., Lee, J. H., Lee, H., Knowles, J. C., & Kim, H. (2022) · Matter · doi:10.1016/j.matt.2022.07.002 · Cited by 16

Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway

Ihn, H. J., Lee, D., Lee, T., Kim, S., Shin, H., Bae, Y. C., Hong, J. M., & Park, E. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142201 · Cited by 16

RANKL pretreatment plays an important role in the differentiation of pit-forming osteoclasts induced by TNF-α on murine bone marrow macrophages.

Yamashita, Y., Ukai, T., Nakamura, H., Yoshinaga, Y., Kobayashi, H., Takamori, Y., Noguchi, S., Yoshimura, A., & Hara, Y. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.06.002 · Cited by 15

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages

Pegoraro, G., Eaton, B., Ulrich, R. L., Lane, D. J., Ojeda, J. F., Bavari, S., DeShazer, D., & Panchal, R. G. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-98 · Cited by 16

Antiresorptive Activity ofBacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation

Choi, S., Moon, S., Yang, H. J., Kwon, D. Y., Son, Y., Yu, R., Kim, Y. S., Kim, S. I., Chae, E. J., Park, S., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/748687 · Cited by 16

Tumor necrosis factor receptor-associated factor 6 is required to inhibit foreign body giant cell formation and activate osteoclasts under inflammatory and infectious conditions

Oya, A., Katsuyama, E., Morita, M., Sato, Y., Kobayashi, T., Miyamoto, K., Nishiwaki, T., Funayama, A., Fujita, Y., Kobayashi, T., et al. (2017) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-017-0890-z · Cited by 16

PSTP-3,5-Me Inhibits Osteoclast Differentiation and Bone Resorption

Cho, E., Chen, Z., Lee, J., Lee, S., & Lee, T. (2019) · Molecules · doi:10.3390/molecules24183346 · Cited by 16

Water Extract of Agastache rugosa Prevents Ovariectomy-Induced Bone Loss by Inhibiting Osteoclastogenesis

Jang, S., Hwang, Y., Kim, T. S., Yang, H. J., Lee, J. H., Seo, Y. H., Park, J.-I., & Ha, H. (2020) · Foods · doi:10.3390/foods9091181 · Cited by 16

Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling

Murakami, A., Matsuda, M., Harada, Y., & Hirata, M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784777 · Cited by 17

Bee venom attenuates Porphyromonas gingivalis and RANKL-induced bone resorption with osteoclastogenic differentiation

Gu, H., An, H., Kim, J., Kim, W., Gwon, M., Kim, H., Han, S. M., Park, I.-S., Park, S. C., Leem, J., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.05.001 · Cited by 16

Molecular signaling in biomaterial-induced foreign body response: current perspectives

Rahaman, S. G., Khan, M. I., Sankaran, K. R., & Rahaman, S. O. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00595.2025 · Cited by 18

Osteoclastogenesis Requires Primary Cilia Disassembly and Can Be Inhibited by Promoting Primary Cilia Formation Pharmacologically

Sutton, M. M., Duffy, M. P., Verbruggen, S. W., & Jacobs, C. R. (2023) · Cells Tissues Organs · doi:10.1159/000531098 · Cited by 15

Cellular and microenvironmental cues that promote macrophage fusion and foreign body response

Stewart, C. L., Hook, A. L., Zelzer, M., Marlow, M., & Piccinini, A. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1411872 · Cited by 17

Orthosilicic acid inhibits human osteoclast differentiation and bone resorption

Magnusson, C., & Ransjö, M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312169 · Cited by 15

Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions

Nomura, T., Aoyama, M., Waguri‐Nagaya, Y., Goto, Y., Suzuki, M., Miyazawa, K., Asai, K., & Goto, S. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.11.020 · Cited by 15

Barley Seedling Extracts Inhibit RANKL‐Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early‐to‐Late Stages of Osteoclastogenesis

Choi, S., Kim, S., Lee, K., Kang, H. J., Lee, M., Park, K., Lee, J. H., Park, K. D., & Seo, W. D. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/6072573 · Cited by 15

Ostm1 from Mouse to Human: Insights into Osteoclast Maturation

Vacher, J., Bruccoleri, M., & Pata, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165600 · Cited by 15

(S)-Equol Is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency–Induced Bone Loss in Mice

Tanaka, M., Fujii, S., Inoue, H., Takahashi, N., Ishimi, Y., & Uehara, M. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac130 · Cited by 16

Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state

Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., et al. (2015) · Bone · doi:10.1016/j.bone.2015.02.025 · Cited by 15

Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget’s disease of bone

Laurier, E., Amiable, N., Gagnon, É., Brown, J. P., & Michou, L. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0495-3 · Cited by 15

Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation

Fujikawa, J., Tanaka, M. H., Itoh, S., Fukushi, T., Kurisu, K., Takeuchi, Y., Morisaki, I., Wakisaka, S., & Abe, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1931-8 · Cited by 15

Double stranded RNA-dependent protein kinase is involved in osteoclast differentiation of RAW264.7 cells in vitro

Teramachi, J., Morimoto, H., Baba, R., Doi, Y., Hirashima, K., & Haneji, T. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.08.006 · Cited by 15

Bioaggregate Inhibits Osteoclast Differentiation, Fusion, and Bone Resorption In Vitro

Tian, J., Qi, W., Zhang, Y., Glogauer, M., Wang, Y., Lai, Z., & Jiang, H. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2015.05.018 · Cited by 15

TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function

Wu, M., Wang, Y., Deng, L., Chen, W., & Li, Y. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.5079 · Cited by 15

The DC-derived protein DC-STAMP influences differentiation of myeloid cells

Eleveld-Trancikova, D., Janssen, R. A. J., Hendriks, I. A. M., Looman, M. W. G., Moulin, V., Jansen, B., Jansen, J., Figdor, C. G., & Adema, G. J. (2007) · Leukemia · doi:10.1038/sj.leu.2404910 · Cited by 15

The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption

Zhang, C., Zhong, Z., Sang, W., Ghorbani, F., Ghalandari, B., Mohamadali, M., Irani, S., Qian, Z., Yi, C., & Yu, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.885507 · Cited by 14

Inhibitory effects of sodium pentosan polysulfate on formation and function of osteoclasts derived from canine bone marrow

Wijekoon, S., Bwalya, E. C., Fang, J., Kim, S., Hosoya, K., & Okumura, M. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1466-4 · Cited by 14

Protocatechualdehyde inhibits receptor activator of nuclear factor kappa‐B ligand ‐induced osteoclastogenesis and attenuates lipopolysaccharide‐induced inflammatory osteolysis

Huang, H., Jiang, W., Hong, K., Cai, J., He, Y., Ma, X., Wu, P., Lang, J., Ma, Y., Huang, C., et al. (2021) · Phytotherapy Research · doi:10.1002/ptr.7088 · Cited by 14

Biological causes of prosthetic joint failure

Revell, P. A. (2008) · Elsevier eBooks · doi:10.1533/9781845694807.3.349 · Cited by 14

L-type Ca2+ channel agonist inhibits RANKL-induced osteoclast formation via NFATc1 down-regulation

Noh, A. L. S. M., Park, H., Zheng, T., Ha, H., & Yim, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.05.009 · Cited by 14

Inhibition of osteoclast differentiation by overexpression of NDRG2 in monocytes

Kang, K., Nam, S., Kim, B., Lim, J. H., Yang, Y. D., Lee, M.-S., & Lim, J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.167 · Cited by 14

Inhibition of RANKL-induced osteoclast differentiation through the downregulation of c-Fos and NFATc1 by Eremochloa ophiuroides (centipedegrass) extract

Choi, B.-Y., PARK, C.-H., NA, Y. H., Bai, H., Cho, J., & Chung, B. Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5015 · Cited by 14

Ultrastructural aspects of foreign body giant cells generated on different substrates

ten Harkel, B., Koopsen, J., van Putten, S. M., van Veen, H. A., Picavet, D. I., de Vries, T. J., Bank, R. A., & Everts, V. E. (2016) · Journal of Structural Biology · doi:10.1016/j.jsb.2016.04.016 · Cited by 14

Osteoporosis and Bone Biology

de Paula, F. J. A., Black, D. M., & Rosen, C. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00029-0 · Cited by 14

Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide-induced bone loss in vivo

Kim, J., Baek, J. M., Ahn, S., Cheon, Y., Park, S., Yang, M., Choi, M. K., & Oh, J. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1300-0 · Cited by 14

TNX deficiency results in bone loss due to an increase in multinucleated osteoclasts

Kajitani, N., Yamada, T., Kawakami, K., & Matsumoto, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.134 · Cited by 16

Factors influencing multinucleated giant cell formation in vitro

Trout, K. L., & Holian, A. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.08.002 · Cited by 14

A Mechanically Stimulated Co-culture in 3-Dimensional Composite Scaffolds Promotes Osteogenic and Anti-osteoclastogenic Activity and M2 Macrophage Polarization

Kontogianni, G., Loukelis, K., Bonatti, A. F., Batoni, E., Maria, C. D., Vozzi, G., Naseem, R., Dalgarno, K. W., Shin, H., Vitale‐Brovarone, C., et al. (2025) · Biomaterials Research · doi:10.34133/bmr.0135 · Cited by 13

Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

Wan, Y., Nemoto, Y. L., Oikawa, T., Takano, K., Fujiwara, T. K., Tsujita, K., & Itoh, T. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202411024 · Cited by 13

Pentamidine Inhibits Titanium Particle-Induced Osteolysis In Vivo and Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation In Vitro

Ihn, H. J., Kim, K., Cho, H.-S., & Park, E. K. (2019) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-019-00186-y · Cited by 13

PF-3845, a Fatty Acid Amide Hydrolase Inhibitor, Directly Suppresses Osteoclastogenesis through ERK and NF-κB Pathways In Vitro and Alveolar Bone Loss In Vivo

Ihn, H. J., Kim, Y., Lim, S.-M., Bae, J., Jung, J., Kim, Y. H., Park, J., Wang, Z., Koh, J., Bae, Y.-C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041915 · Cited by 13

β-Boswellic Acid Inhibits RANKL-Induced Osteoclast Differentiation and Function by Attenuating NF-κB and Btk-PLCγ2 Signaling Pathways

Park, G. D., Cheon, Y., Eun, S. Y., Lee, C. H., Lee, M. S., Kim, J., & Cho, H. J. (2021) · Molecules · doi:10.3390/molecules26092665 · Cited by 13

Isolation and characterization of porcine macrophages and their inflammatory and fusion responses in different stiffness environments

Meli, V. S., Donahue, R. P., Link, J. M., Hu, J. C. Y., Athanasiou, K. A., & Liu, W. F. (2021) · Biomaterials Science · doi:10.1039/d1bm00746g · Cited by 13

Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in POSTmenopausal MRONJ Patients

Park, S.-M., & Lee, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092377 · Cited by 14

Osteoclasts at Bone Remodeling: Order from Order

Takito, J., & Nonaka, N. (2023) · Results and problems in cell differentiation · doi:10.1007/978-3-031-37936-9_12 · Cited by 14

Aconitum pseudo-laeve var. erectum Inhibits Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclastogenesis via the c-Fos/nuclear Factor of Activated T-Cells, Cytoplasmic 1 Signaling Pathway and Prevents Lipopolysaccharide-Induced Bone Loss in Mice

Baek, J. S., Kim, J., Cheon, Y., Park, S., Ahn, S., Yoon, K., Oh, J., & Lee, M. S. (2014) · Molecules · doi:10.3390/molecules190811628 · Cited by 13

Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity

Yeon, J., Kim, H., Kim, K.-J., Lee, J., Won, D. H., Nam, S., Kim, S. H., Kang, H., & Son, Y. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00004 · Cited by 13

A role for tetraspanin proteins in regulating fusion induced by Burkholderia thailandensis

Elgawidi, A., Mohsin, M. I., Ali, F. F., Watts, A., Monk, P. N., Thomas, M. S., & Partridge, L. J. (2020) · Medical Microbiology and Immunology · doi:10.1007/s00430-020-00670-6 · Cited by 13

LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells

Kitano, V. J. F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., et al. (2020) · Journal of Cell Science · doi:10.1242/jcs.243840 · Cited by 13

Blocking of sodium and potassium ion-dependent adenosine triphosphatase-α1 with ouabain and vanadate suppresses cell–cell fusion during RANKL-mediated osteoclastogenesis

Makihira, S., Nikawa, H., Kajiya, M., Kawai, T., Mine, Y., Kosaka, E., Silva, M. J. B., Tobiume, K., & Terada, Y. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.044 · Cited by 13

The chromatin remodeling factor Arid1a cooperates with Jun/Fos to promote osteoclastogenesis by epigenetically upregulating Siglec15 expression

Zhang, Y., Sun, H., Huang, F., Chen, Y., Ding, X., Zhou, C., Wu, Y. T., Zhang, Q., Ma, X., Wang, J., et al. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae042 · Cited by 12

Osteogenic Differentiation of Human Gingival Fibroblasts Inhibits Osteoclast Formation

Ceylan, M., Schoenmaker, T., Hogervorst, J. M. A., Jansen, I. D. C., Schimmel, I. M., Prins, C., Laine, M. L., & de Vries, T. J. (2024) · Cells · doi:10.3390/cells13131090 · Cited by 12

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Miyamoto, T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041138 · Cited by 14

2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose isolated from Galla Rhois suppresses osteoclast differentiation and function by inhibiting NF-κB signaling

Ihn, H. J., Kim, T. H., Kim, K., Kim, G., Jeon, Y., Choi, Y. H., Bae, J., Kim, J., & Park, E. K. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.6.063 · Cited by 11

Endogenous Collagenases Regulate Osteoclast Fusion

Kim, H. J., & Lee, Y. (2020) · Biomolecules · doi:10.3390/biom10050705 · Cited by 12

Effects of Sparganii Rhizoma on Osteoclast Formation and Osteoblast Differentiation and on an OVX-Induced Bone Loss Model

Lee, S., Kim, M., Hong, S., Kim, E. J., Kim, J., Sohn, Y., & Jung, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797892 · Cited by 12

Human circulating monocytes can express receptor activator of nuclear factor‐κB ligand and differentiate into functional osteoclasts without exogenous stimulation

Seta, N., Okazaki, Y., & Kuwana, M. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.4 · Cited by 12

Activated protein C suppresses osteoclast differentiation via endothelial protein C receptor, protease-activated receptor-1, sphingosine 1-phosphate receptor, and apolipoprotein E receptor 2

Yoshida, K., Akita, N., Okamoto, T., Asanuma, K., Uchida, A., Sudo, A., Shimaoka, M., Suzuki, K., & Hayashi, T. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.01.001 · Cited by 12

Paget’s disease of bone: an update on epidemiology, pathogenesis and pharmacotherapy

Gennari, L., Rendina, D., Picchioni, T., Bianciardi, S., Materozzi, M., Nuti, R., & Merlotti, D. (2018) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2018.1500691 · Cited by 13

Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

Bae, S., Shin, M. W., Son, T., Lee, H. S., Chae, J. S., Jeon, S., Oh, G. T., & Kim, K. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0201-3 · Cited by 14

CD13 is a critical regulator of cell–cell fusion in osteoclastogenesis

Ghosh, M., Kelava, T., Vrhovac, I., Kalajzić, I., & Shapiro, L. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-90271-x · Cited by 12

Netrins as prophylactic targets in skeletal diseases: A double-edged sword?

Maruyama, K., Takemura, N., Martino, M. M., Kondo, T., & Akira, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.011 · Cited by 12

Beyond the membrane: rethinking EGFR signaling in physiology and cancer

Jendrisek, G., Mesa, D., Conte, A., Malabarba, M. G., & Sigismund, S. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-06036-6 · Cited by 16

Cell Fusion and Syncytia Formation in Cancer

Sieler, M., & Dittmar, T. (2023) · Results and problems in cell differentiation · doi:10.1007/978-3-031-37936-9_20 · Cited by 11

BCPA {N,N′-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1

Cho, E., Lee, J., Lee, J., Chen, Z., Ahn, S. H., Kim, N. D., Kook, M.-S., Min, S. H., Park, B., & Lee, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113436 · Cited by 11

Bone anti-resorptive effects of coumarins on RANKL downstream cellular signaling: a systematic review of the literature

Tavares, S. J. S., & Lima, V. (2021) · Fitoterapia · doi:10.1016/j.fitote.2021.104842 · Cited by 11

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Katagi, M., Terashima, T., Ohashi, N., Nakae, Y., Yamada, A., Nakagawa, T., Miyazawa, I., Maegawa, H., Okano, J., Suzuki, Y., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02082-5 · Cited by 11

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

Xu, S., Cao, X., Yu, Z., He, W., Pang, Y., Lin, W., Chen, Z., Guo, W., Lu, X., & Lin, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.726361 · Cited by 11

Leishmania infection-induced multinucleated giant cell formation via upregulation of ATP6V0D2 expression

Hong, J., Sanjoba, C., Fujii, W., Yamagishi, J., & Goto, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953785 · Cited by 11

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Maes, C., & Kronenberg, H. M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382040-2.10004-8 · Cited by 12

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Shariati, K., Bedar, M., Huang, K. X., Moghadam, S., Mirzaie, S., LaGuardia, J. S., Chen, W., Kang, Y., Ren, X., & Lee, J. C. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400296 · Cited by 15

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COMMENTARY Macrophage fusion: the making of osteoclasts and giant cells

Vignery, A. (2013)