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Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors

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Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts

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Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts

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Conditional Inactivation of Blimp1 in Adult Mice Promotes Increased Bone Mass

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Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice

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Adenovirus-mediated expression of bone morphogenetic protein-2 activates titanium particle-induced osteoclastogenesis and this effect occurs in spite of the suppression of TNF-α expression by siRNA

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RANKL-Induced Btn2a2 – A T Cell Immunomodulatory Molecule – During Osteoclast Differentiation Fine-Tunes Bone Resorption

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Conditional Disruption of miR17∼92 in Osteoclasts Led to Activation of Osteoclasts and Loss of Trabecular Bone in Part Through Suppression of the miR17‐Mediated Downregulation of Protein‐Tyrosine Phosphatase‐oc in Mice

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Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

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Artemisia capillaris Alleviates Bone Loss by Stimulating Osteoblast Mineralization and Suppressing Osteoclast Differentiation and Bone Resorption

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Monocytes Seeded on Engineered Hypertrophic Cartilage Do Not Enhance Endochondral Ossification Capacity

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Extracellular pH is a critical regulator of osteoclast fusion, size and activation

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The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins

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Isoliensinine Suppresses Osteoclast Formation Through NF-κB Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

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Increased Osteoclastogenesis in Absence of TG2 Is Reversed by Transglutaminase Inhibition—Evidence for the Role for TG1 in Osteoclast Formation

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Morusin Inhibits RANKL-induced Osteoclastogenesis and Ovariectomized Osteoporosis

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Hem1 is essential for ruffled border formation in osteoclasts and efficient bone resorption

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Prostaglandin F2α negatively regulates bone resorption in murine osteoclast development

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Methanol Extract ofCroton PycnanthusBenth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-κB Signaling Pathways

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Bone resorptive activity of human peripheral blood mononuclear cells after fusion with polyethylene glycol

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Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone

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Apremilast inhibits inflammatory osteoclastogenesis

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Osteoclasts-Key Players in Skeletal Health and Disease

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Involvement of cellular protrusions in gamete interactions

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Water extract of tendril of Cucurbita Moschata Duch. suppresses RANKL-induced osteoclastogenesis by down-regulating p38 and ERK signaling

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The Osteoclast

Faccio, R., Choi, Y., Teitelbaum, S. L., & Takayanagi, H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375670-1.10006-8 · Cited by 6

Novel Signaling Pathways and Therapeutic Targets in Osteoclasts

Takayanagi, H. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72009-8_12 · Cited by 6

A novel DCSTAMP antagonist impedes preosteoclast fusion via modulation of RAP1B–RAC1-mediated cytoskeletal remodeling

Zhang, Z., Tao, Z., Zhang, W., Zhang, Z., Zhang, X., Xu, X., Yang, B., Meng, Y., Tao, X., & Zhou, X. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01591-1 · Cited by 6

Giant Cell Tumor of Bone: Biology, Pathophysiology, and Histopathology in the Era of H3F3A

Carneiro, B. D., Brilhante, S. G., Faria, C., Fonseca, S., & Pozza, D. H. (2026) · Biomedicines · doi:10.3390/biomedicines14020449 · Cited by 5

The role and mechanisms of bone microenvironment regulators in osteoporosis: novel intervention strategies for addressing the challenges of aging

Yao, H., Cui, Y., Li, P., Sun, S., Peng, C., & Wu, D. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1783422 · Cited by 5

Harnessing osteoimmunity to treat peri-implant inflammatory osteolysis

Chen, Z., Wang, D., Yang, R., Liu, X., Zhang, G., Lu, Q., Ma, W., & Song, Y. (2024) · Materials Advances · doi:10.1039/d3ma00733b · Cited by 5

MDP/NOD2 enhances RANKL-induced osteoclast differentiation of RAW264.7 cells

Sugimoto, W., Inoue, H., Sougawa, N., Goda, S., & Nishiura, A. (2025) · Journal of Oral Biosciences · doi:10.1016/j.job.2025.100630 · Cited by 5

Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use

Tsuda, E., Fukuda, C., Okada, A., Karibe, T., Hiruma, Y., Takagi, N., Isumi, Y., Yamamoto, T., Hasegawa, T., Uehara, S., et al. (2021) · Bone · doi:10.1016/j.bone.2021.116241 · Cited by 5

Triphenyl hexene, an active substance of Betaone barley water extract, inhibits RANKL-induced osteoclast differentiation and LPS-induced osteoporosis

Lee, Y., Lee, H.-J., Shin, H.-B., Ham, J. R., Lee, M., Lee, M., & Son, Y. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105037 · Cited by 5

Hypoxia‐induced factor 1α promotes osteotomy‐induced regional acceleratory phenomenon via DC‐STAMP mediated membrane fusion

Tang, Y., Li, X., Cai, Y., Bie, M., Tian, Y., Shao, Q., & Kang, F. (2022) · Oral Diseases · doi:10.1111/odi.14215 · Cited by 5

Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice

Wang, X., Shao, L., Richardson, K. K., Ling, W., Warren, A. D., Krager, K. J., Aykin‐Burns, N., Hromas, R., Zhou, D., Almeida, M., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102841 · Cited by 5

Cell Instructive Behavior of Composite Scaffolds in a Co-Culture of Human Mesenchymal Stem Cells and Peripheral Blood Mononuclear Cells

Kontogianni, G., Bonatti, A. F., Maria, C. D., Naseem, R., Coelho, C. C., Alpantaki, K., Batsali, A. K., Pontikoglou, C. G., Quadros, P. A., Dalgarno, K. W., et al. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15050116 · Cited by 5

Unraveling the Mechanisms That Regulate Osteoclast Differentiation: A Review of Current Advances

Zhang, S., Gao, M., Song, S., Zhao, T., Zhou, B.-H., Wang, H., Tian, W., Zhao, W., & Zhao, J. (2025) · genesis · doi:10.1002/dvg.70012 · Cited by 7

La fusion des macrophages : partenaires des cellules Somatiques et cancéreuses ?

Vignery, A., & Gilgenkrantz, S. (2005) · médecine/sciences · doi:10.1051/medsci/200521121070 · Cited by 5

Frequent Upregulation of Cyclin D1 and p16INK4a Expression with Low Ki-67 Scores in Multinucleated Giant Cells

Choi, J.-W., Lee, J. H., & Kim, Y. (2011) · Pathobiology · doi:10.1159/000327359 · Cited by 5

Skeletal Actions of Fasting-Induced Adipose Factor (FIAF)

Lin, J., Naot, D., Watson, M., Costa, J. L., Reid, I. R., Cornish, J., & Grey, A. B. (2013) · Endocrinology · doi:10.1210/en.2013-1238 · Cited by 5

DC-STAMP and TACE Levels are Higher in Patients with Periodontitis

Guardiola, C. J. D. A., Clemente‐Napimoga, J. T., Martinez, E. F., Abdalla, H. B., Peruzzo, D. C., Joly, J. C., & Napimoga, M. H. (2020) · Brazilian Dental Journal · doi:10.1590/0103-6440202002939 · Cited by 5

Niclosamide and its derivative DK‐520 inhibit RANKL‐induced osteoclastogenesis

Jiao, Y., Chen, C., Hu, X.-J., Feng, X., Shi, Z.-Q., Cao, J., Li, Q., & Zhu, Y. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12921 · Cited by 7

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo

Sun, P., Yang, Q., Wang, Y., Peng, J., Zhao, K., Jia, Y., Zhang, T., Lu, X., Han, W., & Qian, Y. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s275128 · Cited by 5

High Expression of DC-STAMP Gene Predicts Adverse Outcomes in AML

Liang, Q., Zhang, L., Wang, W., Zhao, J., Li, Q., Pan, H., Gao, Z., Fang, L., & Shi, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.876689 · Cited by 5

Ethanol Extract of Radix Asteris Suppresses Osteoclast Differentiation and Alleviates Osteoporosis

Lee, S.-J., Yang, H. J., Kim, S., Gu, D. R., Ryuk, J. A., Jang, S., & Ha, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216526 · Cited by 5

Histological and immunohistochemical analyses of osteoclast maturation in giant cell tumor of bone

Agawa, R., Kato, I., Kawabata, Y., Takeyama, M., & Fujii, S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155128 · Cited by 5

Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation

Usui, M., Okamatsu, Y., Sato, T., Hanatani, T., Moritani, Y., Sano, K., Yamamoto, M., & Nakashima, K. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.02.011 · Cited by 5

Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells

Yagi, M., Miyamoto, T. K., Toyama, Y., & Suda, T. (2006) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-006-0697-9 · Cited by 121

The dendritic cell-specific transmembrane protein DC-STAMP is essential for osteoclast fusion and osteoclast bone-resorbing activity

Miyamoto, T. (2006) · Modern Rheumatology · doi:10.1007/s10165-006-0524-0 · Cited by 62

Dendritic cell-specific transmembrane protein (DC-STAMP) regulates bone metabolism through cell-cell fusion of osteoclasts

Iwasaki, R., Miyamoto, T. K., Asoda, S., Nakagawa, T., & Kawana, H. (2009) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2009.03.606

Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells

Miyamoto, H., Suzuki, T., Miyauchi, Y., Iwasaki, R., Kobayashi, T., Sato, Y., Miyamoto, K., Hoshi, H., Hashimoto, K., Yoshida, S., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1575 · Cited by 177

COMMENTARY Macrophage fusion: the making of osteoclasts and giant cells

Vignery, A. (2013)