The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti–HIV-1 activity
Open accessAbstract
Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G), a cytidine deaminase, is a recently recognized innate intracellular protein with lethal activity against human immunodeficiency virus (HIV). Packaged into progeny virions, APOBEC3G enzymatic activity leads to HIV DNA degradation. As a counterattack, HIV virion infectivity factor (Vif) targets APOBEC3G for proteasomal proteolysis to exclude it from budding virions. Based on the ability of APOBEC3G to antagonize HIV infection, considerable interest hinges on elucidating its mechanism(s) of regulation. In this study, we provide the first evidence that an innate, endogenous host defense factor has the potential to promote APOBEC3G and rebuke the virus-mediated attempt to control its cellular host. We identify interferon (IFN)-α as a potent inducer of APOBEC3G to override HIV Vif neutralization of APOBEC3 proteins that pose a threat to efficient macrophage HIV replication. Our data provide a new dimension by which IFN-α mediates its antiviral activity and suggest a means to render the host nonpermissive for viral replication.
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Citations
Cites
1 retracted
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells
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RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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Antiviral Actions of Interferons
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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
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The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
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DNA Deamination Mediates Innate Immunity to Retroviral Infection
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Cited by
Bosinger, S. E., Li, Q., Gordon, S. N., Klatt, N. R., Duan, L., Xu, L., Francella, N., Sidahmed, A., Smith, A. J., Cramer, E. M., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40115 · Cited by 409
APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
Sharma, S., Patnaik, S. K., Thomas Taggart, R., Kannisto, E. D., Enriquez, S. M., Gollnick, P., & Baysal, B. E. (2015) · Nature Communications · doi:10.1038/ncomms7881 · Cited by 264
Chen, T.-W., Lee, C.-C., Liu, H., Wu, C.-S., Pickering, C. R., Huang, P.-J., Wang, J., Chang, I. Y.-F., Yeh, Y.-M., Chen, C.-D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00493-9 · Cited by 115
Rate, A., Upham, J. W., Bosco, A., McKenna, K. L., & Holt, P. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.72 · Cited by 88
Trapp, S., Derby, N. R., Singer, R., Shaw, A., Williams, V. G., Turville, S. G., Bess, J. W., Lifson, J. D., & Robbiani, M. (2009) · Journal of Virology · doi:10.1128/jvi.00023-08 · Cited by 79
Metadata
- Authors
- Peng, G., Lei, K. J., Jin, W., Greenwell-Wild, T., & Wahl, S. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2006-01-17
- Volume
- 203
- Issue
- 1
- Pages
- 41-46
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2137051059
- Cited by
- 293
- References
- 30
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti–HIV-1 activity. https://app.cochat.ai/papers/10.1084/jem.20051512
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- Peng, G., Lei, K. J., Jin, W., Greenwell-Wild, T., & Wahl, S. M. (2006). Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti–HIV-1 activity. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20051512
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