Cited by 1,512T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

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Seddiki, Nabila, Santner-Nanan, Brigitte, Martinson, Jeff, Zaunders, John, Sasson, Sarah, Landay, Alan, Solomon, Michael, Selby, Warwick, Alexander, Stephen I., Nanan, Ralph, Kelleher, Anthony, de St. Groth, Barbara Fazekas·2006·The Journal of Experimental Medicine

DOI 10.1084/jem.20060468PMC PMC2118333

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Abstract

Abnormalities in CD4+CD25+Foxp3+ regulatory T (T reg) cells have been implicated in susceptibility to allergic, autoimmune, and immunoinflammatory conditions. However, phenotypic and functional assessment of human T reg cells has been hampered by difficulty in distinguishing between CD25-expressing activated and regulatory T cells. Here, we show that expression of CD127, the α chain of the interleukin-7 receptor, allows an unambiguous flow cytometry–based distinction to be made between CD127lo T reg cells and CD127hi conventional T cells within the CD25+CD45RO+RA− effector/memory and CD45RA+RO− naive compartments in peripheral blood and lymph node. In healthy volunteers, peripheral blood CD25+CD127lo cells comprised 6.35 ± 0.26% of CD4+ T cells, of which 2.05 ± 0.14% expressed the naive subset marker CD45RA. Expression of FoxP3 protein and the CD127lo phenotype were highly correlated within the CD4+CD25+ population. Moreover, both effector/memory and naive CD25+CD127lo cells manifested suppressive activity in vitro, whereas CD25+CD127hi cells did not. Cell surface expression of CD127 therefore allows accurate estimation of T reg cell numbers and isolation of pure populations for in vitro studies and should contribute to our understanding of regulatory abnormalities in immunopathic diseases.

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N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses
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Background
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Background
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Background
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Background
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CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals
Zaunders, J. J., Danta, M., Bailey, M., Mak, G., Marks, K., Seddiki, N., Xu, Y., Templeton, D. J., Cooper, D. A., Boyd, M. A., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00438 · Cited by 17
“At the same time, in comparison to the effect on Tfh, we also studied the effect of treated HIV-1 infection on other key subsets of CD4+ T cells, including CCR5+ memory CD4+ T cells, CD127+ long-term memory cells, CD103+ tissue-resident memory T (Trm) cells, CD161+ cells, which is a surrogate cell surface maker for Th…”
MethodResultInfluentialSelf-citation
Decreased Frequencies of Peripheral Blood CD4+CD25+CD127–Foxp3+ in Patients with Graves’ Disease and Graves’ Orbitopathy: Enhancing Effect of Insulin Growth Factor-1 on Treg Cells
Pawłowski, P., Grubczak, K., Kostecki, J., Iłendo, E., Moniuszko, M., Pawłowska, M., Ręjdak, R., Reszeć, J., & Myśliwiec, J. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0042-122780 · Cited by 17
“More recent studies demonstrated that the combination of low CD127 expression and high CD25 expression identified potently suppressive cells highly enriched with Foxp3s [18, 19].”
Background
Regulatory immune cells in kidney disease
Lee, V. W., Wang, Y. M., Wang, Y. P., Zheng, D., Polhill, T. S., Cao, Q., Wu, H., Alexander, I. E., Alexander, S. I., & Harris, D. C. H. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00077.2008 · Cited by 17
“In humans, the recent identification of CD127 expression has been the most definitive marker yet of Tregs (73).”
Self-citation
Experimentally induced accumulation of Foxp3+ T cells in upper airway allergy
Skrindo, I., Scheel, C., Johansen, F., & Jahnsen, F. L. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03710.x · Cited by 16
Human regulatory T cells suppress proliferation of B lymphoma cells
Grygorowicz, M. A., Biernacka, M., Bujko, M., Nowak, E., Rymkiewicz, G., Paszkiewicz‐Kozik, E., Borycka, I. S., Bystydzieński, Z., Walewski, J. A., & Markowicz, S. (2016) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1121260 · Cited by 17
“CD127 expression is reportedly inversely correlated with the degree of FOXP3 expression in human peripheral blood CD4 + CD25 + T cells.[28,29] CD4 + CD25 + CD127T cells with the low FOXP3 TSDR methylation level are generally considered as a Treg population generated in thymus, whereas FOXP3-expressing CD4 + CD25 + CD1…”
Background
Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection
Singh, A. K., Salwe, S., Padwal, V., Velhal, S., Sutar, J., Bhowmick, S., Mukherjee, S., Nagar, V. S., Patil, P., & Patel, V. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00182 · Cited by 15
“Expression of CD25 (IL-2Rα) and CD127 (IL-7Rα) on T cells was used to enumerate Tregs (CD3+CD4+CD25highCD127low) (31, 32) (Supplementary Figure S1B).”
Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation
Meyer, B. J., Kunz, N., Seki, S., Higgins, R., Ghosh, A., Hupfer, R., Baldrich, A., Hirsiger, J. R., Jauch, A., Burgener-Gasser, A.-V., et al. (2023) · Journal of Clinical Immunology · doi:10.1007/s10875-023-01547-y · Cited by 16
“4b), in keeping with literature on Treg surface phenotyping [40, 41].”
Result
Janus Kinase Inhibitors Differentially Inhibit Specific Cytokine Signals in the Mesenteric Lymph Node Cells of Inflammatory Bowel Disease Patients
Hindmarch, D. C., Malashanka, S., Shows, D. M., Clarke, A. S., & Lord, J. D. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad173 · Cited by 16
Biomaterial-enhanced treg cell immunotherapy: A promising approach for transplant medicine and autoimmune disease treatment
Mashayekhi, K., Khazaie, K., Faubion, W. A., & Kim, G. B. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.03.030 · Cited by 17
“Consequently, Tregs are now defined as Foxp3 + /CD127low/CD25high/CD4 + cells [13].”
Background
Regulatory T cells in renal disease.
Wang, Y. M., Hu, M., Wang, Y., Polhill, T. S., Zhang, G. Y., Wang, Y., Lee, V. W., Harris, D. C. H., & Alexander, S. I. (2008) · PubMed Central · Cited by 16
Self-citation
A novel human CD4 + T‐cell inducer subset with potent immunostimulatory properties
Ndhlovu, L. C., Leal, F. E., Eccles-James, I. G., Jha, A. R., Lanteri, M. C., Norris, P. J., Barbour, J. D., Wachter, D. J., Andersson, J., Taskén, K., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200939258 · Cited by 16
Molecular Regulation ofCellular Immunity by FOXP3
McMurchy, A. N., Nunzio, S. D., Roncarolo, M. G., Bacchetta, R., & Levings, M. K. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1599-3_3 · Cited by 17
REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA
D'Arena, G. F., Rossi, G., Vannata, B., & Deaglio, S. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.053 · Cited by 16
“Moreover, CD127, that identified the heterodimeric IL-7 receptor, combined with CD4, CD25 and FoxP3, has been shown to better identify Tregs avoiding the contamination of this small cell population (accounting for 1-4% of circulating CD4+ lymphocytes in humans) with activated Tcells.16,17 Tregs and Autoimmunity.”
Determination of a CD4+CD25−FoxP3+ T cells subset in tumor-draining lymph nodes of colorectal cancer secreting IL-2 and IFN-γ
Jafarinia, M., Mehdipour, F., Hosseini, S. V., Ghahramani, L., Hosseinzadeh, M., & Ghaderi, A. A. (2016) · Tumor Biology · doi:10.1007/s13277-016-5345-y · Cited by 16
FOXP3 renders activated human regulatory T cells resistant to restimulation-induced cell death by suppressing SAP expression
Katz, G., Voss, K., Yan, T. F., Kim, Y. C., Kortum, R. L., Scott, D. W., & Snow, A. L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.02.007 · Cited by 16
“The gating strategy is shown in Figure 1, where Tregs were defined as CD4+ CD25hi CD127lo and Tcons were defined as CD4+ CD25lo CD127hi [22].”
Method
Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors
Hirabayashi, K., Yanagisawa, R., Saito, S., Higuchi, Y., Koya, T., Sano, K., Koido, S., Okamoto, M., Sugiyama, H., Nakazawa, Y., et al. (2018) · Anticancer Research · doi:10.21873/anticanres.12465 · Cited by 16
Comparative Analysis of Thymic and Blood Treg in Myasthenia Gravis: Thymic Epithelial Cells Contribute to Thymic Immunoregulatory Defects
Truffault, F., Nazzal, D., Verdier, J., Gradolatto, A., Fadel, É., Roussin, R., Eymard, B., Panse, R. L., & Berrih‐Aknin, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00782 · Cited by 16
“The absence of CD127 is also a hallmark of Treg, yet some CD25hiCD127low CD4 + T cells also contain non-Treg (22, 23).”
Background
Human CD36hi monocytes induce Foxp3+ CD25+ T cells with regulatory functions from CD4 and CD8 subsets
Lee, J. G., Jaeger, K. E., Seki, Y., Lim, Y. W., Cunha, C., Vuchkovska, A., Nelson, A. J., Nikolai-Yogerst, A., Kim, D., Nishimura, M. I., et al. (2021) · Immunology · doi:10.1111/imm.13316 · Cited by 17
Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance
Kaljanac, M., & Abken, H. (2022) · Transplantation · doi:10.1097/tp.0000000000004316 · Cited by 19
“CD127 is a suitable marker in this respect because CD127 inversely correlates with FoxP3 and suppressive function.(69,70) CD4CD25 Treg‚ sorted based on low CD127 expression‚ provide a more potent therapeutic capacity than conventional Treg.”
Natural killer T cells constitutively expressing the interleukin‐2 receptor α chain early in life are primed to respond to lower antigenic stimulation
Ladd, M., Sharma, A., Huang, Q., Wang, A. Y., Xu, L., Genowati, I., Levings, M. K., & Lavoie, P. M. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03304.x · Cited by 18
“3A), but did express high levels of CD127 (the IL-7 receptor alpha chain), which is absent on Tregs and also characteristic of naïve T cells [27, 28].”
Background
Diagnostic Value of Regulatory T Cells: A New Facet of a Much Studied Cell Population
Brown, K., & Wong, W. (2008) · Transplantation · doi:10.1097/tp.0b013e31818f3d2a · Cited by 16
“The low level, or lack of, expression of CD127 has also recently been used to identify Treg (71, 72).”
Role Played by CD4+FOXP3+Regulatory T Cells in Suppression of Host Responses toHaemophilus ducreyiduring Experimental Infection of Human Volunteers
Li, W., Tenner‐Racz, K., Rácz, P., Janowicz, D. M., Fortney, K. R., Katz, B. P., & Spinola, S. M. (2010) · The Journal of Infectious Diseases · doi:10.1086/652781 · Cited by 16
“Human Treg cells can generally be distinguished from effector T cells on the basis of low surface expression of CD127 (interleukin 7 receptor a) [31, 32].”
Background
Expression of IL-7 receptor in human peripheral regulatory T cells
Ciebiada, M., Kasztalska, K., Górska-Ciebiada, M., Barylski, M., & Górski, P. (2012) · Archives of Medical Science · doi:10.5114/aoms.2012.31387 · Cited by 16
Histone methylation mediates plasticity of human FOXP 3+ regulatory T cells by modulating signature gene expressions
He, H., Ni, B., Tian, Y., Tian, Z., Chen, Y., Liu, Z., Yang, X., Lv, Y., & Zhang, Y. (2013) · Immunology · doi:10.1111/imm.12198 · Cited by 16
Immunologic monitoring in kidney transplant recipients
Townamchai, N., Safa, K., & Chandraker, A. K. (2013) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2013.04.002 · Cited by 16
“Effector/memory T cells help prevent infection and cancer, but are associated with acute rejection [56]; they can be detected and differentiated from naïve T cells by staining for CD25, CD45RA, CD45RO, and CD62L [57–59].”
Background
Peripheral and Intestinal CD4+ T Cells With a Regulatory Phenotype in Pediatric Patients With Inflammatory Bowel Disease
Scaleia, R. L., Morrone, S., Stoppacciaro, A., Scarpino, S., Antonelli, M., Bianchi, E., Nardo, G. D., Oliva, S., Viola, F., Cucchiara, S., et al. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181e4d323 · Cited by 16
Expression of CD4+CD25+CD127Low regulatory T cells and cytokines in peripheral blood of patients with primary liver carcinoma
Zhou, W., Deng, J., Chen, Q., Li, R., Xu, X., Guan, Y., Li, W., Xiong, X., Li, H., Li, J., et al. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.44088 · Cited by 16
“CD127 is a recently discovered antigen associated with Tregs that is weakly expressed on Tregs, while the self-activated memory T cell CD127 is strongly expressed; therefore, CD4+CD25+CD127 low/- is used to represent Tregs now[4, 5].”
Background
Phenotypic Correlations between Monocytes and CD4+ T Cells in Allergic Patients
Moniuszko, M., Kowal, K., Jeznach, M., Rusak, M., Dąbrowska, M., & Bodzenta‐Łukaszyk, A. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000343687 · Cited by 16
Cell exhaustion in HIV-1 infection
Seddiki, N., Brezar, V., & Draenert, R. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000087 · Cited by 16
Self-citation
Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer
Du, W., Noyan, F., McCallion, O., Drosdek, V., Kath, J., Glaser, V., Fuster-García, C., Yang, M.-X., Stein, M., Franke, C., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.01.045 · Cited by 12
Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets
Ehx, G., Hannon, M., Beguin, Y. P., Humblet‐Baron, S., & Baron, F. (2015) · Oncotarget · doi:10.18632/oncotarget.6486 · Cited by 15
“Tregs are also featured by a low expression of CD127, the α chain of the IL-7 receptor [5].”
Background
Allergic disease in 8‐year‐old children is preceded by delayed B cell maturation
Strömbeck, A., Nordström, I., Andersson, K., Andersson, H., Johansen, S., Maglio, C., Rabe, H., Adlerberth, I., Wold, A. E., Hesselmar, B., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12922 · Cited by 15
“At 8 years of age, additional markers were included as follows: CD24 and CD38 to distinguish immature/transitional (CD24CD38), mature/na€ıve (CD24CD38), memory (CD24CD38) B cells(23) and CD127 to identify CD4CD25CD127 putative Tregs.(24) We also identified proportions of CD45RA and CD45RO putative Tregs.”
MethodInfluential
Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine
Brezar, V., Hani, L., Surénaud, M., Hubert, A., Lacabaratz, C., Lelièvre, J., Lévy, Y., & Seddiki, N. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006489 · Cited by 15
Self-citation
Short‐term cytokine stimulation reveals regulatory T cells with down‐regulated Foxp3 expression in human peripheral blood
Tabares, P., Berr, S., Langenhorst, D., Sawitzki, B., ten Berge, I. J. M., Tony, H., & Hünig, T. (2017) · European Journal of Immunology · doi:10.1002/eji.201747244 · Cited by 15
Analysis of the immune status from peripheral whole blood with a single-tube multicolor flow cytometry assay
Donaubauer, A.-J., Becker, I., Rühle, P. F., Fietkau, R., Gaipl, U. S., & Frey, B. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.03.003 · Cited by 15
OMIP‐090: A 20‐parameter flow cytometry panel for rapid analysis of cell diversity and homing capacity in human conventional and regulatory T cells
Stroukov, W., Mastronicola, D., Albany, C. J., Catak, Z., Lombardi, G., & Scottà, C. (2023) · Cytometry Part A · doi:10.1002/cyto.a.24720 · Cited by 14
“wherein the very high expression of CD25 combined to the low expression of CD127 describe a well-defined population expressing high levels of the lineage-defining Treg marker FOXP3 [9].”
Background
Sirolimus vs cyclosporine after induction with basiliximab does not promote regulatory T cell expansion in de novo kidney transplantation: Results from a single-center randomized trial
Libetta, C., Esposito, P. B., Gregorini, M., Margiotta, E., Martinelli, C., Borettaz, I., Canevari, M., Rampino, T., Ticozzelli, E., Abelli, M., et al. (2015) · Transplant Immunology · doi:10.1016/j.trim.2015.07.005 · Cited by 15
A flow cytometry based assay for the enumeration of regulatory T cells in whole blood
Hardy, M. Y., Vari, F., Rossetti, T. R., Hart, D. N. J., & Prue, R. L. (2012) · Journal of Immunological Methods · doi:10.1016/j.jim.2012.07.004 · Cited by 15
The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes.
Łuczyński, W., Stasiak‐Barmuta, A., Juchniewicz, A., Wawrusiewicz‐Kurylonek, N., Iłendo, E., Kos, J., Kretowski, A. J., Górska, M., Chyczewski, L., & Bossowski, A. T. (2010) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-008-0113-5 · Cited by 15
A study for proposal of use of regulatory T cells as a prognostic marker and establishing an optimal threshold level for their expression in chronic lymphocytic leukemia
Dasgupta, A., Mahapatra, M., & Saxena, R. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.966245 · Cited by 15
Flow cytometric immunophenotyping of regulatory T cells in chronic lymphocytic leukemia: comparative assessment of various markers and use of novel antibody panel with CD127 as alternative to transcription factor FoxP3
Dasgupta, A., Mahapatra, M., & Saxena, R. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.730614 · Cited by 15
Therapeutic potential of low‐dose IL‐2 in immune thrombocytopenia: An analysis of 3 cases
Zhang, J., Ruan, Y., Xu, X., Wang, H., Tao, Q., Lu, J., Xia, L., Zhang, Q., Wang, J., Wang, Y., et al. (2017) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21601 · Cited by 15
“Interestingly, studies have found that CD4 1 CD25 1 T cells with low expression of CD127 can also be used as reliable markers to define CD4 1 Tregs (10,11).”
Background
Metabolic reprogramming augments potency of human pSTAT3–inhibited iTregs to suppress alloreactivity
Walton, K., Fernandez, M. R., Sagatys, E. M., Reff, J., Kim, J., Lee, M. C., Kiluk, J. V., Hui, J. Y. C., McKenna, D. H., Hupp, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.136437 · Cited by 15
“The final purity of the iTreg (CD4+, CD127-, CD25+, Foxp3+) (28, 29) product was >90% (Fig.”
Background
Circulating and Endometrial Regulatory T Cell and Related Populations in Endometriosis and Infertility: Endometriosis Is Associated with Blunting of Endometrial Cyclical Effects and Reduced Proportions in Moderate-Severe Disease
Hey‐Cunningham, A. J., Riaz, A., Fromm, P. D., Kupresanin, F., Markham, R., & McGuire, H. M. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00658-4 · Cited by 17
“Using multiparametric flow cytometry, through a series of sequential hierarchical gating CD4+ T cells were identified in the blood and/or endometrium of all participants, with Tregs further identified using best practice approach of CD25hi CD127lo CD4+ expression by lymphocytes [40] pro-”
Method
Quantification of Circulating Regulatory T Cells by Flow Cytometry in Kidney Transplant Patients After Basiliximab Induction Therapy
Abadja, F., Alamartine, É., Berthoux, F. C., Mariat, C., Genin, C., & Lambert, C. (2010) · Transplantation · doi:10.1097/tp.0b013e3181bbbd67 · Cited by 15
“9, ACT1, Bb10, BF2, 2A3, BC96, MA251, and 4E3) to detect the CD4 CD25 CD127 regulatory T-cell subset (6,7) was compared.”
Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques
Mason, R. D., Rose, R. D., Seddiki, N., Kelleher, A. D., & Kent, S. J. (2008) · Virology · doi:10.1016/j.virol.2008.08.042 · Cited by 15
Self-citation

Authors: Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., Kelleher, A., & de St. Groth, B. F.
Affiliations: The University of Sydney (AU)
4Department of Paediatrics, University of Sydney, Western Clinical School, Penrith, NSW 2751, Australia
Rush University Medical Center (US)
St Vincent's Hospital Sydney (AU)
Royal Prince Alfred Hospital (AU)
Children's Hospital at Westmead (AU)
UNSW Sydney (AU)
1Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, NSW 2042, Australia
ORCID: Seddiki, Nabila
Zaunders, John
Sasson, Sarah
Landay, Alan
Solomon, Michael
Alexander, Stephen I.
Nanan, Ralph
Kelleher, Anthony
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2006-07-03
Volume: 203
Issue: 7
Pages: 1693-1700
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20060468
PMC: PMC2118333
OpenAlex: W2168628806
Cited by: 1,512
References: 30
Citations by year: 2026: 18 · 2025: 25 · 2024: 32 · 2023: 32 · 2022: 44 · 2021: 49 · 2020: 58 · 2019: 75 · 2018: 51 · 2017: 64 · 2016: 74 · 2015: 63 · 2014: 87 · 2013: 92 · 2012: 116
FWCI: 45.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders: Crohn's and Colitis Foundation of America
Crohn's and Colitis Foundation
Medical Research Council
National Health and Medical Research Council
National Institute of Allergy and Infectious Diseases (P01AI055793, AI55793, U19AI055793)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: regulatory T cells, CD127, interleukin-2 receptor, Foxp3, CD25, CD4+ T cells, naive T cells, effector memory T cells
MeSH terms: Adult, Humans, Infant, Newborn, Lymphocyte Activation, Receptors, Interleukin-2, T-Lymphocyte Subsets, Receptors, Interleukin-7, T-Lymphocytes, Regulatory

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

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