Cited by 1,512T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

Open access

Seddiki, Nabila, Santner-Nanan, Brigitte, Martinson, Jeff, Zaunders, John, Sasson, Sarah, Landay, Alan, Solomon, Michael, Selby, Warwick, Alexander, Stephen I., Nanan, Ralph, Kelleher, Anthony, de St. Groth, Barbara Fazekas·2006·The Journal of Experimental Medicine

DOI 10.1084/jem.20060468PMC PMC2118333

Open this paper in CoChat — free account Open PDF

Abstract

Abnormalities in CD4+CD25+Foxp3+ regulatory T (T reg) cells have been implicated in susceptibility to allergic, autoimmune, and immunoinflammatory conditions. However, phenotypic and functional assessment of human T reg cells has been hampered by difficulty in distinguishing between CD25-expressing activated and regulatory T cells. Here, we show that expression of CD127, the α chain of the interleukin-7 receptor, allows an unambiguous flow cytometry–based distinction to be made between CD127lo T reg cells and CD127hi conventional T cells within the CD25+CD45RO+RA− effector/memory and CD45RA+RO− naive compartments in peripheral blood and lymph node. In healthy volunteers, peripheral blood CD25+CD127lo cells comprised 6.35 ± 0.26% of CD4+ T cells, of which 2.05 ± 0.14% expressed the naive subset marker CD45RA. Expression of FoxP3 protein and the CD127lo phenotype were highly correlated within the CD4+CD25+ population. Moreover, both effector/memory and naive CD25+CD127lo cells manifested suppressive activity in vitro, whereas CD25+CD127hi cells did not. Cell surface expression of CD127 therefore allows accurate estimation of T reg cell numbers and isolation of pure populations for in vitro studies and should contribute to our understanding of regulatory abnormalities in immunopathic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1084/jem.20060468

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses
Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315
CD4+CD25high Regulatory Cells in Human Peripheral Blood
Baecher‐Allan, C., Brown, J. A., Freeman, G. J., & Hafler, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1245 · Cited by 1,889
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., & Horak, I. D. (1993) · Cell · doi:10.1016/0092-8674(93)80067-o · Cited by 1,744
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
von Freeden-Jeffry, U., Vieira, P., Lucian, L., McNeil, T., Burdach, S. E. G., & Murray, R. (1995) · Journal of Experimental Medicine · doi:10.1084/jem.181.4.1519 · Cited by 1,648
Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy
Ehrenstein, M. R., Evans, J. G., Singh, A., Moore, S., Warnes, G., Isenberg, D. A., & Mauri, C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040165 · Cited by 1,253
Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
Ling, E. M., Smith, T. R. F., Nguyen, X. D., Pridgeon, C., Dallman, M. J., Arbery, J., Carr, V. A., & Robinson, D. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15592-x · Cited by 759
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
Gavin, M. A., Clarke, S. R. M., Negrou, E., Gallegos, A. M., & Rudensky, A. Y. (2001) · Nature Immunology · doi:10.1038/ni743 · Cited by 643
Multiple immuno-regulatory defects in type-1 diabetes
Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin‐Su, K., Ten, S., Sanz, M. M., Exley, M. A., Wilson, B., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13605 · Cited by 640
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
Roncador, G., Brown, P. J., Maestre, L., Hüe, S., Martinez-Torrecuadrada, J. L., Ling, K., Pratap, S., Toms, C., Fox, B. C., Cerundolo, V., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526189 · Cited by 592

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 1

2005, Hum. Immunol., 66, 13

Sorted by citations

Items 801–900 of 1,000

Good Manufacturing Practice-Compliant Production and Lot-Release of Ex Vivo Expanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders
Wiesinger, M., Stoica, D., Rößner, S., Lorenz, C., Fischer, A., Atreya, R. N., Neufert, C. F., Atreya, I., Scheffold, A., Schuler‐Thurner, B., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01371 · Cited by 27
Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls
Buhelt, S., Søndergaard, H. B., Oturai, A. B., Ullum, H., von Essen, M. R., & Sellebjerg, F. T. (2019) · Cells · doi:10.3390/cells8060634 · Cited by 29
“On CD4+ T cells, expression of CD25 and the IL-7 receptor α (CD127) identify two CD25+ CD4+ T cell populations: The non-regulatory CD127+CD25+ population and the regulatory CD127loCD25hi (TReg) population [50,51] (Figure 1D).”
Background
Interleukin-7 Immunotherapy
Sportès, C., & Gress, R. E. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72005-0_35 · Cited by 26
“Conversely, mice transgenic for IL-7 develop T cell lymphoproliferative/autoimmune diseases and T cell lymphomas (Fisher et al. 1995; Samaridis et al. 1991 ).”
Background
CD127 immunophenotyping suggests altered CD4+ T cell regulation in primary progressive multiple sclerosis
McKay, F. C., Swain, L. I., Schibeci, S. D., Rubio, J. P., Kilpatrick, T. J., Heard, R. N., Stewart, G. J., & Booth, D. R. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.02.003 · Cited by 26
Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection
Martinuzzi, E., Scotto, M., Waeckel-Énée, E., Brezar, V., Ribeil, J., Endert, P. V., & Mallone, R. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.01.003 · Cited by 26
Effector memory–type regulatory T cells display phenotypic and functional instability
Wendering, D. J., Amini, L., Schlickeiser, S., Farrera-Sal, M., Schulenberg, S., Peter, L., Mai, M., Vollmer, T., Du, W., Stein, M., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn3470 · Cited by 25
“The IL-7 receptor subunit α (CD127) inversely correlates with FoxP3 expression and suppressive function of T reg cells and is used along with CD25 to purify these cells (CD4 + CD25 + CD127 low ) ( 15 ).”
Background
The ‘Treg paradox’ in inflammatory arthritis
Schnell, J. T., Briviesca, R. L., Kim, T., Charbonnier, L., Henderson, L. A., van Wijk, F., & Nigrovic, P. A. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01190-w · Cited by 27
HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients
Schmidt, H.-H., Ge, Y., Hartmann, F. J., Conrad, H., Klug, F., Nittel, S., Bernhard, H., Domschke, C., Schütz, F., Sohn, C., et al. (2013) · OncoImmunology · doi:10.4161/onci.24962 · Cited by 25
“Human Tregs are characterized by the expression of the interleukin-2 (IL-) receptor α chain (CD25), the forkhead box P3 (FOXP3) transcription factor and reduced expression levels of the interleukin-7 receptor (CD127).(10) Tregs often accumulate in the blood and malignant lesions of cancer patients.”
Background
T regulatory cells mediate immunosuppresion by adenosine in peripheral blood, sentinel lymph node and TILs from melanoma patients
Gennaro, P. D., Gerlini, G., Caporale, R., Sestini, S., Brandani, P., Urso, C., Pimpinelli, N., & Borgognoni, L. (2018) · Cancer Letters · doi:10.1016/j.canlet.2017.12.032 · Cited by 25
Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease
Morina, L., Jones, M., Oguz, C., Kaplan, M. J., Gangaplara, A., Fitzhugh, C. D., Kanakry, C. G., Shevach, E. M., & Buszko, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1114780 · Cited by 25
“We also transferred purified CD4+CD25CD127hi T cells to NSG mice and at the peak of their activation in vivo administered a single dose of anti-CD3 and analyzed the mouse splenocytes 12h later (Figure S7).”
BackgroundInfluential
Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB
Jackson-Sillah, D., Cliff, J. M., Mensah, G. I., Dickson, E. K., Sowah, S. A., Tetteh, J. K. A., Addo, K. K., Ottenhoff, T. H. M., Bothamley, G. H., & Dockrell, H. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068121 · Cited by 25
“Other markers have been proposed as Treg markers suggesting the heterogeneous nature of these cells [37,38] and the need to include a variety of markers for their effective isolation and functional characterisation.”
Background
Chronic Graft-versus-Host Disease: How Can We Release Prometheus?
Teshima, T., Wynn, T. A., Soiffer, R. J., Matsuoka, K., & Martin, P. J. (2007) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2007.10.023 · Cited by 25
“Sorted CD4(1)CD25(1)CD127(2) T cells exhibit suppressive activity in vitro [43,44].”
Background
Prolactin down-regulates CD4+CD25hiCD127low/− regulatory T cell function in humans
Legorreta-Haquet, M. V., Chávez-Rueda, A. K., Montoya-Díaz, E., Arriaga‐Pizano, L., Silva‐García, R., Chávez-Sanchéz, L., Moreno-Lafont, M. C., Zenteno, E., & Blanco-Favela, F. A. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0040 · Cited by 25
Development of CD4+CD25+FoxP3+ regulatory T cells from cord blood hematopoietic progenitor cells
Hutton, J. F., Gargett, T., Sadlon, T. J., Bresatz, S., Brown, C. Y., Zola, H., Shannon, M. F., D’Andrea, R. J., & Barry, S. C. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008620 · Cited by 25
“CD4 CD25 Foxp3 HPC-derived cells displayed an inverse correlation with CD127 (94% CD127lo) and coexpressed TCR (90%), CD45RO (70%), CD45RA (55%), CD39 (75%), MHC II (45%), and CD8 (48”
BackgroundInfluential
FOXP3+regulatory T cells as biomarkers in human malignancies
Bignone, P. A., & Banham, A. H. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712590802494022 · Cited by 25
“Critically the ability to separate functional CD4 + CD25 + human Treg populations independently of their CD25 expression, using their reduced levels of CD127 expression, indicated that these additional FOXP3 + populations also have suppressive activity [32,33] .”
Background
From stability to dynamics: understanding molecular mechanisms of regulatory T cells throughFoxp3transcriptional dynamics
Bending, D., & Ono, M. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13194 · Cited by 24
“As the immunosuppressive Treg population is commonly identified by the expression of Foxp3 (as Foxp3+ T cells in mice [2] and Foxp3highCD45RA+ [22,23] or Foxp3+CD127–CD25high T cells [24,25] in humans), the investigation of Foxp3 dynamics in vivo, especially during immune responses, will be key for understanding the i…”
Background
Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity
Betts, B., Locke, F., Sagatys, E. M., Pidala, J., Walton, K., Menges, M., Reff, J., Saha, A., Djeu, J., Kiluk, J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02887 · Cited by 20
“Treg Experiments Tregs were defined as CD4, CD127, CD25, Foxp3 cells (31, 32).”
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
Dao, T., Mun, S. S., Scott, A., Jarvis, C. A., Korontsvit, T., Yang, Z., Liu, L., Klatt, M. G., Guerreiro, M., Selvakumar, A., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1570778 · Cited by 25
CD 127 − and FoxP3 + Expression on CD25 + CD4 + T Regulatory Cells upon Specific Diabetogeneic Stimulation in High‐risk Relatives of Type 1 Diabetes Mellitus Patients
Vrabelová, Z., Hroteková, Z., Hladíková, Z., Böhmová, K., Štechová, K., & Michálek, J. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02074.x · Cited by 25
Immune correlates of anti-BCMA CAR-T products idecabtagene vicleucel and ciltacabtagene autoleucel in a real-world cohort of patients with multiple myeloma
Atanackovic, D., Luetkens, T., Schneider, D., Hu, P., Wang, X., Shetty, A. C., Tallon, L. J., Patel, I., Singh, R., Gebru, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60980-2 · Cited by 27
“We have amended our manuscript accordingly.”
Impaired IL-10–dependent Induction of Tolerogenic Dendritic Cells by CD4+CD25hiCD127lo/− Natural Regulatory T Cells in Human Allergic Asthma
Nguyen, K. D., Vanichsarn, C. T., & Nadeau, K. C. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200905-0761oc · Cited by 24
Identification, frequency, activation and function of CD4+ CD25highFoxP3+ regulatory T cells in children with juvenile idiopathic arthritis
Stelmaszczyk‐Emmel, A., Jackowska, T., Rutkowska‐Sak, L., Marusak-Banacka, M., & Wasik, M. (2011) · Rheumatology International · doi:10.1007/s00296-010-1728-3 · Cited by 24
“In this situation, the assessment of CD127 expression can be very useful [28–30].”
Background
Incomplete Normalization of Regulatory T-Cell Frequency in the Gut Mucosa of Colombian HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment
Rueda, C. M., Velilla, P. A., Chougnet, C. A., & Rugeles, M. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071062 · Cited by 24
“Treg are a subpopulation of CD4+ T-cells, characterized by high constitutive expression of CD25 and FOXP3, and low expression of CD127 [12].”
BackgroundInfluential
Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation
Lucarelli, B., Merli, P., Bertaina, V., & Locatelli, F. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1123091 · Cited by 24
Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease
Brown, C. Y., Sadlon, T. J., Hope, C. M., Wong, Y. Y., Wong, S. W., Liu, N., Withers, H., Brown, K. A., Bandara, V., Gundsambuu, B., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01269 · Cited by 25
“In search of surface-expressed surrogates of the suppressor function or FOXP3 expression, two groups observed that reduced expression of the IL7 receptor (CD127) is a hallmark of the human Treg phenotype (11, 12).”
Background
Intestinal Regulatory T Cells
Figliuolo, V. R., Jamwal, D. R., & Kiela, P. R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6407-9_9 · Cited by 28
Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination
Elias, G., Meysman, P., Bartholomeus, E., Neuter, N. D., Keersmaekers, N., Suls, A., Jansens, H., Souquette, A. H., Reu, H. D., Emonds, M., et al. (2022) · eLife · doi:10.7554/elife.68388 · Cited by 26
Circulating Regulatory T Cells in “Clinical” Monoclonal B-Cell Lymphocytosis
D'Arena, G. F., Rossi, G., Minervini, M. M., Savino, L., D’Auria, F., Laurenti, L., Principe, M. I. D., Deaglio, S., Biagi, A., Martino, L. D., et al. (2011) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201102400410 · Cited by 24
New ways to separate Graft‐versus‐Host Disease and Graft‐versus‐Tumour effects after allogeneic haematopoietic stem cell transplantation
Kotsiou, E., & DAVIES, J. K. (2012) · British Journal of Haematology · doi:10.1111/bjh.12115 · Cited by 24
Subpopulations of helper T lymphocytes in tuberculous pleurisy
Tong, Z.-H., & Shi, H. (2013) · Tuberculosis · doi:10.1016/j.tube.2013.02.014 · Cited by 24
Phenotypic analysis of human peripheral blood regulatory T cells (CD4+FOXP3+CD127lo/–) ex vivo and after in vitro restimulation with malaria antigens
Finney, O. C., Riley, E. M., & Walther, M. R. (2009) · European Journal of Immunology · doi:10.1002/eji.200939708 · Cited by 24
Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue
Rane, L., Rahman, S. M. M. A., Magalhaes, I., Ahmed, R. K. S., Spångberg, M., Kondova, I. I., Verreck, F. A. W., Andersson, J., Brighenti, S., & Maeurer, M. J. (2011) · Genes and Immunity · doi:10.1038/gene.2011.29 · Cited by 25
The Effector T Cell Response to Ryegrass Pollen Is Counterregulated by Simultaneous Induction of Regulatory T Cells
Mittag, D., Scholzen, A., Varese, N. P., Baxter, L., Paukovics, G., Harrison, L. C., Rolland, J. M., & O’Hehir, R. E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901036 · Cited by 24
“Human studies have mostly identified Tregs based on high expression of CD25 and Foxp3 and, in some cases, low expression of CD127 (2, 3).”
Background
Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a “proallergic” milieu
Reefer, A. J., Hulse, K. E., Lannigan, J. A., Solga, M. D., Wright, P. W., Kelly, L. A., Patrie, J. T., Chapman, M. D., & Woodfolk, J. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.023 · Cited by 24
“The increased cell size of the majority of TSLPr(1) T cells was readily evident on microscopic examination compared with resting effector cells identified by low DNA content and high expression of CD127 (Fig 5, A, gate C).(20,21) Collectively, these observations indicate that TSLPr is expressed on TH2 cells, and a lar…”
Circulating level of regulatory T cells in rheumatic heart disease: An observational study
Mukhopadhyay, S., Varma, S., Kumar, H. N. M., Yusaf, J., Goyal, M., Mehta, V., & Tyagi, S. (2016) · Indian Heart Journal · doi:10.1016/j.ihj.2015.08.009 · Cited by 24
Comparative Analysis of the Regulatory T Cells Dynamics in Peripheral Blood in Human and Porcine Polytrauma
Serve, R., Sturm, R., Schimunek, L., Störmann, P., Heftrig, D., Teuben, M. P. J., Oppermann, E., Horst, K., Pfeifer, R., Simon, T. P., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00435 · Cited by 24
“found 84% of CD4+CD25+ cells to be CD127low in human peripheral blood (71).”
Background
Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity
Mitchell, J. M., Kelly, J., Kvedaraite, E., Greenwood, T. V. B., Henter, J., Pellicci, D. G., Berzins, S. P., & Kannourakis, G. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108418 · Cited by 24
A New Subset of Human Naive CD8+ T Cells Defined by Low Expression of IL-7Rα
Alves, N. L., van Leeuwen, E. M. M., Remmerswaal, E. B. M., Vrisekoop, N., Tesselaar, K., Roosnek, E. E., ten Berge, I. J. M., & van Lier, R. A. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.221 · Cited by 24
“In addition, low expression of IL-7R has been recently proposed to be used as a marker for regulatory CD4 T cells, which have been defined as anergic to TCR-CD28 stimulation (29, 30).”
Background
Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25− T cells from atopic and nonatopic donors
Ahern, D., Lloyd, C. M., & Robinson, D. S. (2009) · Allergy · doi:10.1111/j.1398-9995.2008.01962.x · Cited by 24
“Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.”
BackgroundInfluential
Regulatory T-cell dysfunction and its implication for cell therapy
Valentini, N., Cier, C. J. R., & Lamarche, C. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad051 · Cited by 24
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination
Mukherjee, S., Chakraborty, S., Basak, U., Pati, S., Dutta, A., Dutta, S., Roy, D., Banerjee, S., Ray, A., Sa, G., et al. (2023) · Discover Oncology · doi:10.1007/s12672-023-00787-z · Cited by 23
Cutting Edge Issues in Autoimmune Hepatitis
Vergani, D., & Mieli‐Vergani, G. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-010-8236-9 · Cited by 23
“Another major feature of T-regs is low or absent expression of the IL-7 receptor [60, 62–64].”
Background
Therapeutic HIV-1 vaccine
Seddiki, N., & Lévy, Y. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000444 · Cited by 21
“Of note, CD4þ Tregs express a reduced level of IL-7Ra chain [45] but an increased level of IL-2Ra chain, and are dependent on IL-2 signalling [46].”
BackgroundSelf-citation
Regulatory T Cells and Their Association with Serum Markers and Symptoms in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Kailashiya, V., Singh, U., Rana, R. S., Singh, N. K., Dash, D., & Kailashiya, J. (2018) · Immunological Investigations · doi:10.1080/08820139.2018.1527852 · Cited by 23
“It had been observed that there is a ~ 90% correlation between CD4+ CD25+ CD127low/dim T cells and FoxP3 expression, thus CD4+ CD25+ CD127low/dim surface expression can be utilized for identification of Treg (Azimi et al., 2016; Seddiki et al., 2006).”
Background
Mapping the extent of heterogeneity of human CCR5+ CD4+ T cells in peripheral blood and lymph nodes
Zaunders, J., Munier, C. M. L., McGuire, H. M., Law, H. L., Howe, A., Xu, Y., Groth, B. F. D. S., Schofield, P., Christ, D., Milner, B., et al. (2020) · AIDS · doi:10.1097/qad.0000000000002503 · Cited by 22
“Treg gates were set as previously described [46]”
MethodSelf-citation
Shear Stress Enhances the Paracrine-Mediated Immunoregulatory Function of Human Periodontal Ligament Stem Cells via the ERK Signalling Pathway
Suwittayarak, R., Klincumhom, N., Ngaokrajang, U., Namangkalakul, W., Ferreira, J. N., Pavasant, P., & Osathanon, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137119 · Cited by 23
The influence of bone marrow- and synovium-derived mesenchymal stromal cells from osteoarthritis patients on regulatory T cells in co-culture
Hagmann, S., Gotterbarm, T., Müller, T. H., Bäsig, A.-M., Gantz, S., Dreher, T., Kämmerer, P. W., Frank, S., Zeifang, F., & Moradi, B. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12122 · Cited by 23
Identification of a human Th1-like IFNγ-secreting Treg subtype deriving from effector T cells
Venigalla, R. K., Guttikonda, P. J., Eckstein, V., Ho, A. D., Sertel, S., Lorenz, H., & Tretter, T. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.06.004 · Cited by 23
Immune modulation of inflammatory conditions: regulatory T cells for treatment of GvHD
Haase, D., Starke, M., Puan, K. J., Lai, T. S., & Rötzschke, O. (2012) · Immunologic Research · doi:10.1007/s12026-012-8267-9 · Cited by 23
Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7
Kielsen, K., Ryder, L. P., Lennox-Hvenekilde, D., Gad, M., Nielsen, C. H., Heilmann, C. J., Ifversen, M., Pedersen, A. E., & Müller, K. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.023 · Cited by 22
Immune signatures for HIV-1 and HIV-2 induced CD4+T cell dysregulation in an Indian cohort
Salwe, S., Singh, A. K., Padwal, V., Velhal, S., Nagar, V. S., Patil, P., Deshpande, A. K., & Patel, V. V. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-3743-7 · Cited by 23
Antileukemic T-cell Responses Can Be Predicted by the Composition of Specific Regulatory T-cell Subpopulations
Schick, J., Vogt, V., Zerwes, M., Kroell, T., Kraemer, D. M., Köhne, C., Hausmann, A., Buhmann, R., Tischer, J., & Schmetzer, H. M. (2013) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31829180e7 · Cited by 23
miR-155 is differentially expressed in Treg subsets, which may explain expression level differences of miR-155 in HIV-1 infected patients
Seddiki, N., Swaminathan, S., Phetsouphanh, C., & Kelleher, A. D. (2012) · Blood · doi:10.1182/blood-2012-02-412874 · Cited by 23
Self-citation
Regulatory T cells as modulators of chronic allograft dysfunction
Issa, F., Chandrasekharan, D. P., & Wood, K. J. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.06.005 · Cited by 22
“Treg expressing low levels of CD127, the a-chain of the IL-7 receptor, were found to be 5 times more potent at this ability, in line with previous studies demonstrating enhanced suppressive qualities of CD127 Treg [32,33].”
Result
Regulatory T Cells in Melanoma Revisited by a Computational Clustering of FOXP3+ T Cell Subpopulations
Fujii, H., Josse, J., Tanioka, M., Miyachi, Y., Husson, F., & Ono, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1402695 · Cited by 22
“It was proposed that FOXP3 T cells could be classified into three functionally different subpopulations: CD45RO (equivalent to CD45RA(2)) FOXP3 T cells as classical Tregs with suppressive activity (9, 11), CD45RO(2) (or CD45RA) FOXP3 naive Tregs (9, 12, 13), and FOXP3CD45RO non-Tregs (9, 14, 15).”
BackgroundInfluential
Translational immune correlates of indirect antibody immunization in a randomized phase II study using scheduled combination therapy with carboplatin/paclitaxel plus oregovomab in ovarian cancer patients
Battaglia, A., Buzzonetti, A., Fossati, M., Scambia, G., Fattorossi, A., Madiyalakan, M. R., Mahnke, Y. D., & Nicodemus, C. F. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02456-z · Cited by 21
Standardization of Workflow and Flow Cytometry Panels for Quantitative Expression Profiling of Surface Antigens on Blood Leukocyte Subsets: An HCDM CDMaps Initiative
Kužílková, D., Puñet‐Ortiz, J., Aui, P. M., Fernández, J., Fišer, K., Engel, P., van Zelm, M. C., & Kalina, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827898 · Cited by 22
“The lymphoid tube was expanded with CD25, CD127 and CXCR5, enabling the detection of T regulatory cells (Tregs) (29) and Tfh cells (30, 31) with a total of 15 defined cell subsets (Table 2).”
Method
Type 1 diabetes and T regulatory cells
Essawy, B. E., & Li, X. C. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.04.009 · Cited by 22
Monitoring of CD4+CD25highIL-7Rαhigh activated T Cells in Kidney Transplant Recipients
Vallotton, L., Hadaya, K., Venetz, J.-P., Buehler, L. H., Ciuffreda, D., Nseir, G., Deak, L. C., Villard, J., Pantaleo, G., & Pascual, M. A. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09611010 · Cited by 22
The impact of circulating suppressor cells in multiple myeloma patients on clinical outcome of DLIs
Franssen, L. E., van de Donk, N. W. C. J., Emmelot, M. E., Roeven, M. W. H., Schaap, N. P., Dolstra, H., Hobo, W. A., Lokhorst, H. M., & Mutis, T. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.48 · Cited by 22
Discrete changes in circulating regulatory T cells during infliximab treatment of Crohn's disease
Hvas, C. L., Kelsen, J., Agnholt, J. S., Dige, A. K., Christensen, L. A., & Dahlerup, J. F. (2010) · Autoimmunity · doi:10.3109/08916930903509064 · Cited by 22
“, the absence of the IL-7 receptor a chain CD127 in CD4þCD25þT cells [34,35].”
Background
Characterisation and expression analysis of the chicken interleukin-7 receptor alpha chain
van Haarlem, D. A., van Kooten, P. J. S., Rothwell, L. M., Kaiser, P., & Vervelde, L. (2009) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2009.05.001 · Cited by 22
“Moreover, surface expression of CD127 (IL-7Ra) combined with CD25 (IL-2Ra) can differentiate between human regulatory and conventional CD4+ T cells in adult peripheral blood [8].”
Background
Immune Correlates of Herpes Zoster in HIV-Infected Children and Youth
Weinberg, A., Huang, S., Song, L., Fenton, T., Williams, P. L., Patterson, J., Tovar-Salazar, A., & Levin, M. J. (2011) · Journal of Virology · doi:10.1128/jvi.06623-11 · Cited by 22
“In a multivariable analysis controlling for CD4 cell percentages, higher CD4 TGF- and CD4 PD1 percentages remained significantly associated with the occurrence of HZ (P 0.03), but CD4 IL-10 percentages did not.”
BackgroundInfluential
CD4+/CD25 high /FoxP3+/CD127− regulatory T cells in bronchoalveolar lavage fluid of lung cancer patients
Osińska, I., Stelmaszczyk‐Emmel, A., Polubiec-Kownacka, M., Dziedzic, D. A., & Domagala-Kulawik, J. J. (2016) · Human Immunology · doi:10.1016/j.humimm.2016.07.235 · Cited by 22
Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study
Narsale, A. A., Moya, R., Ma, J., Anderson, L. J., Wu, D. Y., Garcia, J. M., & Davies, J. D. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12424 · Cited by 22
Regulatory T cells in HIV infection: Who’s suppressing what?
Seddiki, N., & Kelleher, A. D. (2008) · Current HIV/AIDS Reports · doi:10.1007/s11904-008-0004-6 · Cited by 22
Self-citation
CD4dimCD25bright Treg cell frequencies above a standardized gating threshold are similar in asthmatics and controls
Hoffmann, H. J., Malling, T. H., Topçu, A., Ryder, L. P., Nielsen, K. R., Varming, K., Dahl, R., Omland, Ø., & Sigsgaard, T. (2007) · Cytometry Part A · doi:10.1002/cyto.a.20389 · Cited by 22
Evaluation of regulatory T cells (Tregs) alterations in patients with multiple myeloma treated with bortezomib or lenalidomide plus dexamethasone: correlations with treatment outcome
Hadjiaggelidou, C., Mandala, E., Terpos, E., Yiannaki, E. E., Markala, D., Triantafyllou, T., Παπαθεοδώρου, Α., Gkastari, V., Verrou, E., Papanikolaou, A., et al. (2019) · Annals of Hematology · doi:10.1007/s00277-019-03657-3 · Cited by 21
Fueling chimeric antigen receptor T cells with cytokines.
Jin, J., Cheng, J., Huang, M., Luo, H., & Zhou, J. (2020) · PubMed Central · Cited by 21
CD4+CD25+ T regulatory cells in renal transplantation
Cheung, J., Zahorowska, B., SURANYI, M. G., Wong, J. K. W., Diep, J., Spicer, S. T., Verma, N. D., Hodgkinson, S. J., & Hall, B. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1017683 · Cited by 21
Perspective on Potential Clinical Applications of Recombinant Human Interleukin‐7
Sportès, C., Gress, R. E., & Mackall, C. L. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05075.x · Cited by 21
Células T regulatórias naturais (T REGS) em doenças reumáticas
Cruvinel, W. D. M., Mesquita, D., Araújo, J. A. P., Salmazi, K. C., Kallas, E. G., & Andrade, L. E. C. (2008) · Revista Brasileira de Reumatologia · doi:10.1590/s0482-50042008000600007 · Cited by 21
High purity and yield of natural Tregs from cord blood using a single step selection method
Figueroa-Tentori, D., Querol, S., Dodi, I. A., Madrigal, J. A., & Duggleby, R. C. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.09.019 · Cited by 21
The Majority of HIV Type 1 DNA in Circulating CD4 + T Lymphocytes Is Present in Non-Gut-Homing Resting Memory CD4 + T Cells
McBride, K. L., Xu, Y., Bailey, M., Seddiki, N., Suzuki, K., Murray, J. M., Gao, Y., Yan, C., Cooper, D. A., Kelleher, A. D., et al. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2012.0351 · Cited by 21
Self-citation
CD4+FoxP3+ regulatory T-cells in human systemic lupus erythematosus
Suen, J., & Chiang, B. (2012) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2012.05.013 · Cited by 21
“humans and mice.(3,6) Thus, a combination of CD127, CD3, and CD4 expression can be used to isolate viable FoxP3þ T-cells (CD3þCD4þCD127e) for functional studies of Tregs.”
Background
What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?
Craenmehr, M. H. C., Heidt, S., Eikmans, M., & Claas, F. H. J. (2016) · HLA · doi:10.1111/tan.12737 · Cited by 21
Healthy Preterm Newborns Show an Increased Frequency of CD 4+ CD 25high CD 127low FOXP 3+ Regulatory T Cells with a Naive Phenotype and High Expression of Gut‐Homing Receptors
Rennó, C., Nadaf, M. I. V., Zago, C. A., Carneiro-Sampaio, M. M. S., & Palmeira, P. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12435 · Cited by 22
Phenotypic Alterations Involved in CD8+ Treg Impairment in Systemic Sclerosis
Negrini, S. M., Fenoglio, D., Parodi, A., Kalli, F., Battaglia, F., Nasi, G., Curto, M., Tardito, S., Ferrera, F., & Filaci, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00018 · Cited by 21
“CD127, the IL-7 receptor α chain, is reportedly a useful marker for identifying memory and effector T cells, while its expression is down-modulated on CD4+CD25+ Treg cells (18, 25, 26).”
Background
Death receptor 3 signaling enhances proliferation of human regulatory T cells
Bittner, S., Knoll, G., & Ehrenschwender, M. (2017) · FEBS Letters · doi:10.1002/1873-3468.12632 · Cited by 21
Frontline Science: Low regulatory T cells predict perioperative major adverse cardiovascular and cerebrovascular events after noncardiac surgery
Scholz, A. S., Handke, J., Gillmann, H.-J., Zhang, Q., Dehne, S., Janssen, H., Arens, C., Espeter, F., Sander, A., Giannitsis, E., et al. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.5hi1018-392rr · Cited by 21
HIV-Specific TGF- β -Positive CD4 + T Cells Do Not Express Regulatory Surface Markers and Are Regulated by CTLA-4
Elrefaei, M., Burke, C. M., Baker, C. A. R., Jones, N. G., Bousheri, S., Bangsberg, D. R., & Cao, H. (2009) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2009.0149 · Cited by 21
“7,8”
Influential
A prospective study of T- and B-lymphocyte subpopulations, CD81 expression levels on B cells and regulatory CD4+CD25+CD127low/−FoxP3+ T cells in patients with chronic HCV infection during pegylated interferon-alpha2a plus ribavirin treatment
Soldevila, B., Alonso, N., Martínez-Arconada, M. J., Morillas, R. M., Planas, R., Sanmartı́, A., & Martínez-Cáceres, E. M. (2010) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2010.01317.x · Cited by 21
Multiple Unit Pooled Umbilical Cord Blood is a Viable Source of Therapeutic Regulatory T Cells
Milward, K. F., Issa, F., Hester, J., Figueroa-Tentori, D., Madrigal, J. A., & Wood, K. J. (2012) · Transplantation · doi:10.1097/tp.0b013e31827722ed · Cited by 20
The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting
Coghill, J. M., Carlson, M., Moran, T. P., & Serody, J. S. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190802272684 · Cited by 20
“Two groups have shown that the CD4þCD25þCD127dim fraction is enriched for regulatory activity compared with the CD4þCD25þ CD127 population, and that highly pure Tregs can be isolated using flow-cytometry based approaches [33,34].”
Background
IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life
Hsu, P. S., Lai, C. L., Hu, M., Santner‐Nanan, B., Dahlstrom, J. E., Lee, C. H., Ajmal, A., Bullman, A., Arbuckle, S. M., Saedi, A. A., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701533 · Cited by 19
“CD25 (IL-2RA) expression compared with Tconv cells (24), we”
Self-citation
Regulatory T Cell Therapy Following Liver Transplantation
Yu, J.-J., Liu, Z., Li, C., Wei, Q., Zheng, S., Saeb‐Parsy, K., & Xu, X. (2020) · Liver Transplantation · doi:10.1002/lt.25948 · Cited by 20
“CD127 is thus often used in conjunction with CD25 as a marker for the identification and purification of Tregs, defined as CD4+CD25+CD127low T cells.(30,31) However, CD4+CD25+FOXP3+ remains the most widely accepted marker for Tregs,(29) and almost all ongoing clinical trials use CD4+FOXP3+ Tregs.”
Method
The Importance of the Transcription Factor Foxp3 in the Development of Primary Immunodeficiencies
Mertowska, P., Mertowski, S., Podgajna, M., & Grywalska, E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11040947 · Cited by 19
“Studies have shown that cells with the CD4+CD25+CD127low phenotype may also be present in some IPEX patients who suffer from decreased FOXP3 expression due to the occurrence of hypomorphic mutations [55,195].”
Background
Low-dose interleukin-2 therapy in systemic lupus erythematosus
Cava, A. L. (2023) · Rheumatology and Immunology Research · doi:10.2478/rir-2023-0021 · Cited by 19
Regulatory cells, cytokine pattern and clinical risk factors for asthma in infants and young children with recurrent wheeze
Borrego, L. M., Arroz, M. J., Videira, P. A., Martins, C. G., Guimarães, H., Nunes, G., Papoila, A. L., & Trindade, H. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03253.x · Cited by 20
Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma: A crucial role of CD25−FOXP3− T cells
Kakita, N., Kanto, T., Itose, I., Kuroda, S., Inoue, M., Matsubara, T., Higashitani, K., Miyazaki, M., Sakakibara, M., Hiramatsu, N., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27535 · Cited by 20
“In recent studies, the expression of IL-7 receptor alpha chain (CD127) was found to be downregulated in Tregs and CD127 expression to be inversely correlated with FOXP3 expression.(11,12) Moreover, CD127-negative T cells are endowed with suppressive ability irrespective of their CD25 expression.”
Background
Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor‐ligand interactions
Kueng, H. J., Manta, C., Haiderer, D., Reichl, V., Schmetterer, K. G., Neunkirchner, A., Byrne, R. A., Scheinecker, C., Steinberger, P., Seed, B., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-137281 · Cited by 20
“Interleukin receptor components such as the IL-2R -chain (CD25) and IL-7R -chain (CD127) are differentially represented among human T-cell subsets (43), and it has been reported that the CD4 CD25CD127 (IL-2R IL-7R ) phenotype identifies natural Treg cells (43).”
Background
Homeostatic T Cell Proliferation after Islet Transplantation
Monti, P., & Piemonti, L. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/217934 · Cited by 20
Increased Circulating CD4+CD25+CD127low/neg Regulatory T-cells as a Prognostic Biomarker in Acute Pancreatitis
Minkov, G., Yovtchev, Y. P., & Halacheva, K. S. (2017) · Pancreas · doi:10.1097/mpa.0000000000000894 · Cited by 20
IPEX as a Consequence of Alternatively Spliced FOXP3
Mailer, R. K. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.594375 · Cited by 20
“Accordingly, the most suppressive human Treg-cell population has been identified to express a CD4+CD25+CD127low phenotype (39, 40).”
Background
Distribution of CD4pos -, CD8pos – and Regulatory T Cells in the Upper and Lower Gastrointestinal Tract in Healthy Young Subjects
Tauschmann, M., Prietl, B., Treiber, G. M., Gorkiewicz, G., Kump, P. K., Högenauer, C., & Pieber, T. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080362 · Cited by 20
“5, anti-CD4 PE, anti-CD8 V500, anti-CD25 PE-Cy7 and anti-CD127 FITC (BD Biosciences, USA).”
BackgroundInfluential
The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements
Scheinberg, P., Melenhorst, J. J., Hill, B. J., Keyvanfar, K., Barrett, A. J., Price, D. A., & Douek, D. C. (2007) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.01.005 · Cited by 20
“…of CD25 and recent studies have suggested that the downregulation of the IL-7 receptor (CD127) or the isolation of CD45RA + naïve CD4+CD25 high may serve as a discriminator between T R and non-T R CD4+ T cells (Hoffmann et al., 2006; Liu et al., 2006; Seddiki et al., 2006) without the need for ICS.”
Background
Special regulatory T‐cell review: T‐cell dependent suppression revisited
Basten, A., & Groth, B. F. D. S. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02772.x · Cited by 20
Foxp3 as a marker of tolerance induction versus rejection
Zhang, G. Y., Hu, M., Wang, Y. M., & Alexander, S. I. (2009) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32831da83c · Cited by 20
Self-citation
The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes
Lašťovička, J. (2013) · Research in Endocrinology · doi:10.5171/2013.119348 · Cited by 18
Impact of Mononuclear Cell Infiltration on Chondrodestructive MMP/ADAMTS Production in Osteoarthritic Knee Joints—An Ex Vivo Study
Platzer, H., Nees, T. A., Reiner, T., Tripel, E., Gantz, S., Hagmann, S., Moradi, B., & Rosshirt, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051279 · Cited by 19
“Among the different T cell subtypes, regulatory CD4+CD25+CD127low/- T cells (Treg) [30,31], which are known for their anti-inflammatory characteristics and their role in the maintenance of self-tolerance [32–35], were detected in OA synovium and synovial fluid [29].”
Background

Authors: Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., Kelleher, A., & de St. Groth, B. F.
Affiliations: The University of Sydney (AU)
4Department of Paediatrics, University of Sydney, Western Clinical School, Penrith, NSW 2751, Australia
Rush University Medical Center (US)
St Vincent's Hospital Sydney (AU)
Royal Prince Alfred Hospital (AU)
Children's Hospital at Westmead (AU)
UNSW Sydney (AU)
1Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, NSW 2042, Australia
ORCID: Seddiki, Nabila
Zaunders, John
Sasson, Sarah
Landay, Alan
Solomon, Michael
Alexander, Stephen I.
Nanan, Ralph
Kelleher, Anthony
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2006-07-03
Volume: 203
Issue: 7
Pages: 1693-1700
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20060468
PMC: PMC2118333
OpenAlex: W2168628806
Cited by: 1,512
References: 30
Citations by year: 2026: 18 · 2025: 25 · 2024: 32 · 2023: 32 · 2022: 44 · 2021: 49 · 2020: 58 · 2019: 75 · 2018: 51 · 2017: 64 · 2016: 74 · 2015: 63 · 2014: 87 · 2013: 92 · 2012: 116
FWCI: 45.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders: Crohn's and Colitis Foundation of America
Crohn's and Colitis Foundation
Medical Research Council
National Health and Medical Research Council
National Institute of Allergy and Infectious Diseases (P01AI055793, AI55793, U19AI055793)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: regulatory T cells, CD127, interleukin-2 receptor, Foxp3, CD25, CD4+ T cells, naive T cells, effector memory T cells
MeSH terms: Adult, Humans, Infant, Newborn, Lymphocyte Activation, Receptors, Interleukin-2, T-Lymphocyte Subsets, Receptors, Interleukin-7, T-Lymphocytes, Regulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks