PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

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1. Genetic and Epigenetic Regulation of PD-1 Expression
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2. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
   Yan Zhang, Shengdong Huang, Dejun Gong, Yanghua Qin, Qian Shen · 2010 · Cellular and Molecular Immunology
3. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy
   Fumihiko Tsushima, Sheng Yao, Tahiro Shin, Andrew S. Flies, Sarah J. Flies, Haiying Xu, Koji Tamada, Drew M. Pardoll, Lieping Chen · 2007 · Blood
4. Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
   R. M. S. Wong, Ronaldo Scotland, Roy Lau, Chenhui Wang, Alan J. Korman, W. Martin Kast, Jeffrey S. Weber · 2007 · International Immunology
5. PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention
   DE Kaufmann, Bruce D. Walker · 2009 · The Journal of Immunology
6. The Programmed Death-1 Immune-Suppressive Pathway: Barrier to Antitumor Immunity
   Suzanne Ostrand‐Rosenberg, Lucas A. Horn, Samuel T. Haile · 2014 · The Journal of Immunology
7. Interaction of human PD-L1 and B7-1
   Manish J. Butte, Victor Peña‐Cruz, Mi‐Jung Kim, Gordon James Freeman, Arlene H. Sharpe · 2008 · Molecular Immunology
8. Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy
   Cynthia L. Gay, Ronald J. Bosch, Justin Ritz, Jason M. Hataye, Evgenia Aga, Randall L. Tressler, Stephen W. Mason, Carey K. Hwang, Dennis M. Grasela, Neelanjana Ray et al. · 2017 · The Journal of Infectious Diseases
9. PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
   Guoping Peng, Shuping Li, Wei Wu, Xufei Tan, Yiqiong Chen, Zhi Chen · 2007 · Molecular Immunology
10. IL-10, T cell exhaustion and viral persistence
    Shawn D. Blackburn, E. John Wherry · 2007 · Trends in Microbiology
11. The Immunoregulatory Role of CD244 in Chronic Hepatitis B Infection and its Inhibitory Potential on Virus-Specific CD8+ T-cell Function
    Bijan Raziorrouh, Winfried Schraut, Tilman J. Gerlach, Daniela Nowack, Norbert H. Grüner, Axel Ulsenheimer, Roman Zachoval, Martin Wächtler, Michael Spannagl, Jürgen Haas et al. · 2010 · Hepatology
12. PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
    Rémi Fromentin, Sandrina DaFonseca, Cecilia Theresa Costiniuk, Mohamed El Far, Francesco A. Procopio, Frederick M. Hecht, Rebecca Hoh, Steven G. Deeks, Daria J. Hazuda, Sharon R. Lewin et al. · 2019 · Nature Communications
13. Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection
    Sang‐Jun Ha, Scott N. Mueller, E. John Wherry, Daniel L. Barber, Rachael D. Aubert, Arlene H. Sharpe, Gordon James Freeman, Rafi Ahmed · 2008 · The Journal of Experimental Medicine
14. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
    Chen Ying Zhu, Kaori Sakuishi, Sheng Xiao, Zhiyi Sun, Sarah Zaghouani, Guangxiang Gu, Chao Wang, Dewar J. Tan, Chuan Wu, Manu Rangachari et al. · 2015 · Nature Communications
15. Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
    Adriano Boasso, Gene M. Shearer · 2007 · Clinical Immunology
16. Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
    Hertoghs, Kirsten M.L., Moerland, Perry D., van Stijn, Amber, Remmerswaal, Ester B.M., Yong, Sila L., van de Berg, Pablo J.E.J., van Ham, S. Marieke, Baas, Frank, ten Berge, Ineke J.M., van Lier, René A.W. · 2010 · Journal of Clinical Investigation
17. Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
    Tsvetelina Pentcheva‐Hoang, Emily Corse, James Patrick Allison · 2009 · Immunological Reviews
18. High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 + and CD4 + T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
    Victoria O Kasprowicz, Julian Schulze zur Wiesch, Thomas Kuntzen, Brian E. Nolan, Steven Longworth, Andrew C. Berical, Jenna Blum, Cory M. McMahon, Laura L. Reyor, Nahel Elias et al. · 2007 · Journal of Virology
19. Optimizing a Multicolor Immunophenotyping Assay
    Yolanda D. Mahnke, Mario Roederer · 2007 · Clinics in Laboratory Medicine
20. Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
    Takuya Yamamoto, David A. Price, Joseph Paul Casazza, Guido Ferrari, Martha Nason, Pratip K. Chattopadhyay, Mario Roederer, Emma Gostick D, Peter D. Katsikis, Daniel C. Douek et al. · 2011 · Blood
21. The T-Cell Response to HIV
    Bruce D. Walker, A J McMichael · 2012 · Cold Spring Harbor Perspectives in Medicine
22. Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion
    Christine M. Bucks, Jillian Norton, Alina C. Boesteanu, Yvonne M. Mueller, Peter D. Katsikis · 2009 · The Journal of Immunology
23. The Immune Response to Human CMV
    Corinna La Rosa, Don J. Diamond · 2012 · Future Virology
24. Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells
    Szu-Han Huang, Yanqin Ren, Allison S. Thomas, Dora Chan, Stefanie Mueller, Adam R. Ward, Shabnum Patel, Catherine M. Bollard, Carolina Colli Cruz, Sara Karandish et al. · 2018 · Journal of Clinical Investigation
25. Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques
    Jacob D. Estes, Shari N. Gordon, Ming Zeng, Ann Chahroudi, Richard M. Dunham, Silvija I. Staprans, Cavan Reilly, Guido Silvestri, Ashley T. Haase · 2008 · The Journal of Immunology
26. Humanized mouse models to study human diseases
    Michael A. Brehm, Leonard D. Shultz, Dale L. Greiner · 2010 · Current Opinion in Endocrinology Diabetes and Obesity
27. The Role of IL-10 in Regulating Immunity to Persistent Viral Infections
    Elizabeth B. Wilson, David G. Brooks · 2010 · Current topics in microbiology and immunology
28. PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion
    Roberto Tinoco, Florent Carrette, Monique L. Henriquez, Dennis C. Otero, Jonathan Magaña, Marcus Bosenberg, Susan L. Swain, Linda M. Bradley · 2016 · Immunity
29. Interaction of SHP‐2 SH2 domains with PD‐1 ITSM induces PD‐1 dimerization and SHP‐2 activation
    Patsoukis, Nikolaos, Duke-Cohan, Jonathan S., Chaudhri, Apoorvi, Aksoylar, Halil-Ibrahim, Wang, Qi, Council, Asia, Berg, Anders, Freeman, Gordon J., Boussiotis, Vassiliki A. · 2020 · Communications Biology
30. Inhibitors of the PD-1 Pathway in Tumor Therapy
    Martin W. LaFleur, Yuki Muroyama, Charles G. Drake, Arlene H. Sharpe · 2018 · The Journal of Immunology
31. Dynamic Programmed Death 1 Expression by Virus-Specific CD8 T Cells Correlates With the Outcome of Acute Hepatitis B
    Zheng Zhang, Ji‐Yuan Zhang, E. John Wherry, Bo Jin, Bin Xu, Zhengsheng Zou, Shu–Ye Zhang, Baosen Li, Hui–Feng Wang, Hao Wu et al. · 2008 · Gastroenterology
32. PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce, Jorge R. Almeida, Martin Larsen, Laurine Haro, Brigitte Autran, Gordon James Freeman, Victor Appay · 2007 · AIDS
33. SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas, David A. Price, Joseph J. Mattapallil, David R. Ambrozak, Christof Geldmacher, Valentina Cecchinato, Monica Vaccari, Elżbieta Anna Tryniszewska, Emma Gostick D, Mario Roederer et al. · 2007 · Blood
34. Coinfection With HIV-1 and HCV—A One-Two Punch
    Arthur Y. Kim, Raymond T. Chung · 2009 · Gastroenterology
35. Immunology and the elusive AIDS vaccine
    Herbert W. Virgin, Bruce D. Walker · 2010 · Nature
36. Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells
    Ben Youngblood, Alessandra Noto, Filippos Porichis, Rama S. Akondy, Zaza M. Ndhlovu, James W Austin, Rebeka Bordi, Francesco A. Procopio, Toshiyuki Miura, Todd M. Allen et al. · 2013 · The Journal of Immunology
37. Immunity, ageing and cancer
    Derhovanessian, Evelyna, Solana, Rafael, Larbi, Anis, Pawelec, Graham · 2008 · Immunity & Ageing
38. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection
    Guoping Peng, Shuping Li, Wei Wu, Zhen Sun, Yiqiong Chen, Zhi Chen · 2007 · Immunology
39. PD-1 Expression and IL-2 Loss of Cytomegalovirus- Specific T Cells Correlates with Viremia and Reversible Functional Anergy
    Urban Sester, Daniela Presser, Jan Dirks, Barbara Christine Gärtner, H. Köhler, Martina Sester · 2008 · American Journal of Transplantation
40. Responsiveness of HIV-specific CD4 T cells to PD-1 blockade
    Filippos Porichis, Douglas S. Kwon, Jennifer Zupkosky, Daniel P. Tighe, Ashley M. McMullen, Mark A. Brockman, David F. Pavlik, Marta Rodríguez‐García, Florencia Pereyra, Gordon James Freeman et al. · 2011 · Blood
41. CD8+ Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells
    Nichole R. Klatt, Emi Shudo, Alex M. Ortiz, Jessica C. Engram, Mirko Paiardini, Benton Lawson, Michael D. Miller, James G. Else, Ivona Pandrea, Jacob D. Estes et al. · 2010 · PLoS Pathogens
42. PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients
    Julien J. Fourcade, Pavol Kudela, Zhaojun Sun, Hongmei Shen, Stephanie R. Land, Diana E. Lenzner, Philippe Guillaume, Immanuel F. Luescher, Cindy Sander, Soldano Ferrone et al. · 2009 · The Journal of Immunology
43. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
    Scott N. Mueller, Vijay K. Vanguri, Sang‐Jun Ha, Erin E. West, Mary E Keir, Jonathan N. Glickman, Arlene H. Sharpe, Rafi Ahmed · 2010 · Journal of Clinical Investigation
44. TIM-3 and Its Regulatory Role in Immune Responses
    Chen Ying Zhu, Ana Carrizosa Anderson, Vijay Kumar Kuchroo · 2010 · Current topics in microbiology and immunology
45. Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance
    Ruihan Tang, Manu Rangachari, Vijay Kumar Kuchroo · 2019 · Seminars in Immunology
46. PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
    Ravi Dyavar Shetty, Vijayakumar Velu, Kehmia Titanji, Steven E. Bosinger, Gordon James Freeman, Guido Silvestri, Rama Rao Amara · 2012 · Journal of Clinical Investigation
47. Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options
    Vijayakumar Velu, Ravi Dyavar Shetty, Marie Larsson, Esaki Muthu Shankar · 2015 · Retrovirology
48. CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
    Yoav Peretz, Zhong He, Yu Shi, Bader Yassine‐Diab, Jean-Philippe Goulet, Rebeka Bordi, Ali Filali‐Mouhim, Jean-Baptiste Loubert, Mohamed El Far, Franck P. Dupuy et al. · 2012 · PLoS Pathogens
49. CTL quality and the control of human retroviral infections
    Charles R. M. Bangham · 2009 · European Journal of Immunology
50. siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen–specific CD8+ T cells
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51. Insights into B cells and HIV ‐specific B‐cell responses in HIV ‐infected individuals
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52. Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype
    Alexandre Harari, Cristina Cellerai, Felicitas Bellutti Enders, Josef Köstler, Laura Codarri Deak, Gonzalo Tapia, Onur Boyman, Erika Castro, Silvana Gaudieri, IAN R. JAMES et al. · 2007 · Proceedings of the National Academy of Sciences
53. Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
    Marcia Bellon, Christophe Nicot · 2017 · Viruses
54. Partial restoration of T‐cell function in aged mice by in vitro blockade of the PD‐1/ PD‐L1 pathway
    Celine Silva Lages, Ian Paul Lewkowich, Alyssa A. Sproles, Marsha A. Wills-Karp, Claire Anne Chougnet · 2010 · Aging Cell
55. Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure
    Alexandre Harari, Felicitas Bellutti Enders, Cristina Cellerai, Pierre‐Alexandre Bart, Giuseppe Pantaleo · 2009 · Journal of Virology
56. Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
    Joseph N. Blattman, E. John Wherry, Sang‐Jun Ha, Robbert G. Van der Most, Rafi Ahmed · 2009 · Journal of Virology
57. Emergence of Polyfunctional CD8+T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
    Manuela Rehr, Julia Cahenzli, Anna Haas, David A. Price, Emma Gostick D, Milo Huber, Urs W. Karrer, Annette Oxenius · 2008 · Journal of Virology
58. Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 + T cell functions during chronic viral infection
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59. Increased Programmed Death-1 Expression on CD4+ T Cells in Cutaneous T-Cell Lymphoma
    Sara S. Samimi, Bernice M. Benoit, Katherine G. Evans, E. John Wherry, Louise C. Showe, Maria Wysocka, Alain H. Rook · 2010 · Archives of Dermatology
60. Role of PD-1 in HIV Pathogenesis and as Target for Therapy
    Filippos Porichis, DE Kaufmann · 2011 · Current HIV/AIDS Reports
61. PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A
    Nikolaos Patsoukis, Duygu Sari, Vassiliki A. Boussiotis · 2012 · Cell Cycle
62. The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses
    Alison Crawford, E. John Wherry · 2009 · Current Opinion in Immunology
63. Vaccine Design for CD8 T Lymphocyte Responses
    Richard A. Koup, Daniel C. Douek · 2011 · Cold Spring Harbor Perspectives in Medicine
64. HIV-specific CD8+ T cells and HIV eradication
    Richard Brad Jones, Bruce D. Walker · 2016 · Journal of Clinical Investigation
65. Harnessing the immune system to treat cancer
    Nina Bhardwaj · 2007 · Journal of Clinical Investigation
66. Notch signaling regulates PD‐1 expression during CD8 + T‐cell activation
    Mélissa Mathieu, Natacha Cotta‐Grand, Jean‐François Daudelin, Paméla Thébault, Nathalie Labrecque · 2012 · Immunology and Cell Biology
67. Elevated Expression Levels of Inhibitory Receptor Programmed Death 1 on Simian Immunodeficiency Virus-Specific CD8 T Cells during Chronic Infection but Not after Vaccination
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68. Immune Checkpoint Protein Inhibition for Cancer: Preclinical Justification for CTLA-4 and PD-1 Blockade and New Combinations
    Kathryn Anissa Baksh, Jeffrey S. Weber · 2015 · Seminars in Oncology
69. Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells
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70. Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment
    Simona Urbani, Barbara Amadei, Daniela Tola, Giuseppe Pedrazzi, Luca Sacchelli, Maria Cristina Cavallo, Alessandra Orlandini, Gabriele Missale, Carlo I. Ferrari · 2008 · Journal of Hepatology
71. B7-H1 Up-Regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B
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72. Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates
    Mohamed B. Ezzelarab, Alan F. Zahorchak, L. Lu, Adrián E. Morelli, Geetha Chalasani, Anthony Jake Demetris, Fadi G. Lakkis, Martin N. Wijkstrom, Noriko Murase, Abhi Humar et al. · 2013 · American Journal of Transplantation
73. Memory T cells need CD28 costimulation to remember
    Alina C. Boesteanu, Peter D. Katsikis · 2009 · Seminars in Immunology
74. The Role of LAT in Increased CD8 + T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1
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75. Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques
    Kehmia Titanji, Vijayakumar Velu, Lakshmi S. Chennareddi, Matam Vijay–Kumar, Andrew T. Gewirtz, Gordon James Freeman, Rama Rao Amara · 2010 · Journal of Clinical Investigation
76. Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo
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77. BCL-2 Antagonism Sensitizes CTL-Resistant HIV Reservoirs to Elimination Ex Vivo
    Yanqin Ren, Szu-Han Huang, Shabnum Patel, Winiffer D. Conce Alberto, Dean Magat, Dughan J. Ahimovic, Amanda B. Macedo, Ryan Durga, Dora Chan, Elizabeth A. Zale et al. · 2019 · Journal of Clinical Investigation
78. Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm
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79. The hallmarks of CMV-specific CD8 T-cell differentiation
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80. Plasmacytoid and Myeloid Dendritic Cells With a Partial Activation Phenotype Accumulate in Lymphoid Tissue During Asymptomatic Chronic HIV-1 Infection
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81. Elite control of HIV infection: implications for vaccine design
    Brett M. Baker, Brian L. Block, Alissa C. Rothchild, Bruce D. Walker · 2008 · Expert Opinion on Biological Therapy
82. On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection
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83. Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion
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84. MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells
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85. PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination
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86. Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders
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87. Cutting Edge: Programmed Death-1 Defines CD8+CD122+ T Cells as Regulatory versus Memory T Cells
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88. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum
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89. Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model
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90. Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection
    Constantinos Petrovas, Benjamin Chaon, David R. Ambrozak, David A. Price, J. Joseph Melenhorst, Brenna J. Hill, Christof Geldmacher, Joseph Paul Casazza, Pratip K. Chattopadhyay, Mario Roederer et al. · 2009 · The Journal of Immunology
91. Mechanisms of CD8 + T cell‐mediated suppression of HIV/SIV replication
    Julia Bergild McBrien, Nitasha Kumar, Guido Silvestri · 2018 · European Journal of Immunology
92. PD-1 Expression on Natural Killer Cells and CD8 + T Cells During Chronic HIV-1 Infection
    S. Norris, Adam Coleman, Leticia Kuri-Cervantes, Mark Bower, Mark Richard Nelson, Martin Rhys Goodier · 2012 · Viral Immunology
93. The B7 family of immunoregulatory receptors: A comparative and evolutionary perspective
    John D. Hansen, Louis Du Pasquier, Marie‐Paule Lefranc, Virginie Lopez, Abdenour Benmansour, Pierre Boudinot · 2008 · Molecular Immunology
94. Is immunosenescence influenced by our lifetime “dose” of exercise?
    Turner, James E. · 2016 · Biogerontology
95. Programmed death ligand 1 is over‐expressed by neutrophils in the blood of patients with active tuberculosis
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96. The Single-Cell Phenotypic Identity of Human CD8+ and CD4+ T Cells
    Jolanda Brummelman, Karolina Pilipow, Enrico Lugli · 2018 · International review of cytology
97. Cutting Edge: Programmed Death-1 Expression Is Increased on Immunocytes in Chronic Hepatitis C Virus and Predicts Failure of Response to Antiviral Therapy: Race-Dependent Differences
    Lucy Golden‐Mason, Jared S. Klarquist, Abdus S. Wahed, Hugo R. Rosen · 2008 · The Journal of Immunology
98. Regulation of Virus-Specific CD4+ T Cell Function by Multiple Costimulatory Receptors during Chronic HIV Infection
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99. Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview
    Kesava Rao Venkata Kurapati, Venkata Subba Rao Atluri, Thangavel Samikkannu, Gabriella Garcia, Madhavan Nair · 2016 · Frontiers in Microbiology
100. Molecular signatures of T-cell inhibition in HIV-1 infection
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