The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
Open accessAbstract
Integrins are critical for hemostasis and thrombosis because they mediate both platelet adhesion and aggregation. Talin is an integrin-binding cytoplasmic adaptor that is a central organizer of focal adhesions, and loss of talin phenocopies integrin deletion in Drosophila. Here, we have examined the role of talin in mammalian integrin function in vivo by selectively disrupting the talin1 gene in mouse platelet precursor megakaryocytes. Talin null megakaryocytes produced circulating platelets that exhibited normal morphology yet manifested profoundly impaired hemostatic function. Specifically, platelet-specific deletion of talin1 led to spontaneous hemorrhage and pathological bleeding. Ex vivo and in vitro studies revealed that loss of talin1 resulted in dramatically impaired integrin αIIbβ3-mediated platelet aggregation and β1 integrin–mediated platelet adhesion. Furthermore, loss of talin1 strongly inhibited the activation of platelet β1 and β3 integrins in response to platelet agonists. These data establish that platelet talin plays a crucial role in hemostasis and provide the first proof that talin is required for the activation and function of mammalian α2β1 and αIIbβ3 integrins in vivo.
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Transmission Electron Microscopy
Williams, D. B., & Carter, C. B. (2009) · Springer eBooks · doi:10.1007/978-0-387-76501-3 · Cited by 3,963
Ruggeri, Z. M. (2002) · Nature Medicine · doi:10.1038/nm1102-1227 · Cited by 1,589
Self-citationTalin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., & Calderwood, D. A. (2003) · Science · doi:10.1126/science.1086652 · Cited by 1,209
Self-citationExposure of platelet fibrinogen receptors by ADP and epinephrine.
Bennett, J. S., & Vilaire, G. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109597 · Cited by 849
Savage, B., Almus-Jacobs, F., & Ruggeri, Z. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81607-4 · Cited by 801
Self-citationHodivala-Dilke, K. M., McHugh, K. P., Tsakiris, D. A., Rayburn, H., Crowley, D., Ullman-Culleré, M., Ross, F. P., Coller, B. S., Teitelbaum, S., & Hynes, R. O. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5487 · Cited by 740
Calderwood, D. A., Zent, R., Grant, R., Rees, D. J. G., Hynes, R. O., & Ginsberg, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28071 · Cited by 720
Self-citationIntegrins: dynamic scaffolds for adhesion and signaling in platelets
Shattil, S. J., & Newman, P. J. (2004) · Blood · doi:10.1182/blood-2004-04-1257 · Cited by 601
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
Nieswandt, B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2120 · Cited by 548
Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature · doi:10.1038/nature01147 · Cited by 441
Cited by
Rapid leukocyte migration by integrin-independent flowing and squeezing
Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397
Self-citationThe final steps of integrin activation: the end game
Shattil, S. J., Kim, C., & Ginsberg, M. H. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2871 · Cited by 1,086
Self-citationThe Tail of Integrins, Talin, and Kindlins
Moser, M., Legate, K. R., Zent, R., & Fässler, R. (2009) · Science · doi:10.1126/science.1163865 · Cited by 760
Talin – the master of integrin adhesions
Klapholz, B., & Brown, N. H. (2017) · Journal of Cell Science · doi:10.1242/jcs.190991 · Cited by 309
Harburger, D. S., Bouaouina, M., & Calderwood, D. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809233200 · Cited by 304
Metadata
- Authors
- Petrich, B. G., Marchese, P., Ruggeri, Z. M., Spiess, S., Weichert, R. A. M., Ye, F., Tiedt, R., Skoda, R. C., Monkley, S. J., Critchley, D. R., & Ginsberg, M. H.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-12-17
- Volume
- 204
- Issue
- 13
- Pages
- 3103-3111
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2111803487
- Cited by
- 309
- References
- 31
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Petrich, B. G., Marchese, P., Ruggeri, Z. M., Spiess, S., Weichert, R. A. M., Ye, F., Tiedt, R., Skoda, R. C., Monkley, S. J., Critchley, D. R., & Ginsberg, M. H. (2007). Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20071800
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