The DOI matches its Crossref record.
Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow
Open accessAbstract
We have used confocal videomicroscopy in real time to delineate the adhesive interactions supporting platelet thrombus formation on biologically relevant surfaces. Type I collagen fibrils exposed to flowing blood adsorb von Willebrand factor (vWF), to which platelets become initially tethered with continuous surface translocation mediated by the membrane glycoprotein Ib alpha. This step is essential at high wall shear rates to allow subsequent irreversible adhesion and thrombus growth mediated by the integrins alpha2beta1 and alpha(IIb)beta3. On subendothelial matrix, endogenous vWF and adsorbed plasma vWF synergistically initiate platelet recruitment, and alpha2beta1 remains key along with alpha(IIb)beta3 for normal thrombus development at all but low shear rates. Thus, hemodynamic forces and substrate characteristics define the platelet adhesion pathways leading to thrombogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Platelets in inflammation and thrombosis
Wagner, D. D., & Burger, P. C. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000095974.95122.ec · Cited by 570
von Willebrand factor, Jedi knight of the bloodstream
Springer, T. A. (2014) · Blood · doi:10.1182/blood-2014-05-378638 · Cited by 444
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
Crittenden, J. R., Bergmeier, W., Zhang, Y., Piffath, C. L., Liang, Y., Wagner, D. D., Housman, D. E., & Graybiel, A. M. (2004) · Nature Medicine · doi:10.1038/nm1098 · Cited by 406
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
Petrich, B. G., Marchese, P., Ruggeri, Z. M., Spiess, S., Weichert, R. A. M., Ye, F., Tiedt, R., Skoda, R. C., Monkley, S. J., Critchley, D. R., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071800 · Cited by 309
Self-citationGray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice
Deppermann, C., Cherpokova, D., Nurden, P., Schulz, J.-N., Thielmann, I., Kraft, P., Vögtle, T., Kleinschnitz, C., Dütting, S., Krohne, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69210 · Cited by 200
Metadata
- Authors
- Savage, B., Almus-Jacobs, F., & Ruggeri, Z. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 94
- Issue
- 5
- Pages
- 657-666
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2030665169
- Cited by
- 801
- References
- 0
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81607-4
- The paper
- Savage, B., Almus-Jacobs, F., & Ruggeri, Z. M. (1998). Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow. Cell. https://doi.org/10.1016/s0092-8674(00)81607-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
