The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vaccine protection against Staphylococcus aureus pneumonia
Open accessAbstract
Staphylococcus aureus pneumonia causes significant mortality in hospitalized or healthy individuals, and recent increases in morbidity are attributed to the rapid spread of methicillin-resistant S. aureus (MRSA) strains, which are often not susceptible to antibiotic therapy. α-Hemolysin (Hla), a secreted pore-forming toxin, is an essential virulence factor of MRSA in a mouse model of S. aureus pneumonia. We show that the level of Hla expression by independent S. aureus strains directly correlates with their virulence. Active immunization with a mutant form of Hla (HlaH35L), which cannot form pores, generates antigen-specific immunoglobulin G responses and affords protection against staphylococcal pneumonia. Moreover, transfer of Hla-specific antibodies protects naive animals against S. aureus challenge and prevents the injury of human lung epithelial cells during infection. Thus, Hla vaccination or immunotherapy may prevent S. aureus pneumonia in humans.
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Gillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514
Poring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F. R., & Schneewind, O. (2007) · Nature Medicine · doi:10.1038/nm1207-1405 · Cited by 492
Self-citationVaccine assembly from surface proteins of Staphylococcus aureus
Stranger-Jones, Y. K., Bae, T., & Schneewind, O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606863103 · Cited by 309
Self-citationPatel, A. H., Nowlan, P., Weavers, E. D., & Foster, T. (1987) · Infection and Immunity · doi:10.1128/iai.55.12.3103-3110.1987 · Cited by 280
Cited by
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718
Community-associated meticillin-resistant Staphylococcus aureus
DeLeo, F. R., Otto, M., Kreiswirth, B. N., & Chambers, H. F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61999-1 · Cited by 1,506
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
DeLeo, F. R., & Chambers, H. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38226 · Cited by 512
Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457
Inoshima, I., Inoshima, N., Wilke, G. A., Powers, M. E., Frank, K. M., Wang, Y., & Wardenburg, J. B. (2011) · Nature Medicine · doi:10.1038/nm.2451 · Cited by 21
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Metadata
- Authors
- Wardenburg, J. B., & Schneewind, O.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-02-11
- Volume
- 205
- Issue
- 2
- Pages
- 287-294
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2150491739
- Cited by
- 407
- References
- 4
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- green
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