The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Staphylococcus aureus synthesizes adenosine to escape host immune responses
Open accessAbstract
Staphylococcus aureus infects hospitalized or healthy individuals and represents the most frequent cause of bacteremia, treatment of which is complicated by the emergence of methicillin-resistant S. aureus. We examined the ability of S. aureus to escape phagocytic clearance in blood and identified adenosine synthase A (AdsA), a cell wall–anchored enzyme that converts adenosine monophosphate to adenosine, as a critical virulence factor. Staphylococcal synthesis of adenosine in blood, escape from phagocytic clearance, and subsequent formation of organ abscesses were all dependent on adsA and could be rescued by an exogenous supply of adenosine. An AdsA homologue was identified in the anthrax pathogen, and adenosine synthesis also enabled escape of Bacillus anthracis from phagocytic clearance. Collectively, these results suggest that staphylococci and other bacterial pathogens exploit the immunomodulatory attributes of adenosine to escape host immune responses.
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“…aureus is the leading cause of bloodstream, lower respiratory tract, skin, and soft tissue infections (Klevens et al., 2006; Klevens et al., 2007) because of its unique ability to multiply in blood or other host tissues and cause persistent infections (Lowy, 1998).”
BackgroundThe complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
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Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium
Eltzschig, H. K., Ibla, J. C., Furuta, G. T., Leonard, M. O., Jacobson, K. A., Enjyoji, K., Robson, S. C., & Colgan, S. P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030891 · Cited by 499
LYSOSTAPHIN: A NEW BACTERIOLYTIC AGENT FOR THE STAPHYLOCOCCUS
Schindler, C. A., & Schuhardt, V. T. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.3.414 · Cited by 482
Mazmanian, S. K., Ton-That, H., Su, K., & Schneewind, O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032523999 · Cited by 372 · cited 1×
“Sortase A anchors a large spectrum of different polypeptides in the staphylococcal envelope, using a transpeptidation mechanism and LPXTG motif sorting signal at the C terminus of surface proteins (Mazmanian et al., 2002).”
BackgroundSelf-citationGaspar, A. H., Marraffini, L. A., Glass, E. M., DeBord, K. L., Ton-That, H., & Schneewind, O. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.13.4646-4655.2005 · Cited by 82
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Cited by
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,533
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Regulation of Inflammation by Adenosine
Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng, A. G., McAdow, M., Kim, H. K., Bae, T., Missiakas, D. M., & Schneewind, O. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001036 · Cited by 324
Self-citationA play in four acts: Staphylococcus aureus abscess formation
Cheng, A. G., DeDent, A. C., Schneewind, O., & Missiakas, D. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.01.007 · Cited by 310
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Metadata
- Authors
- Thammavongsa, V., Kern, J. W., Missiakas, D. M., & Schneewind, O.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-09-28
- Volume
- 206
- Issue
- 11
- Pages
- 2417-2427
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129234516
- Cited by
- 252
- References
- 8
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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