The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
Open accessAbstract
Forkhead box P3 (FOXP3)+CD4+CD25+ inducible regulatory T (iT reg) cells play an important role in immune tolerance and homeostasis. In this study, we show that the transforming growth factor-β (TGF-β) induces the expression of the Runt-related transcription factors RUNX1 and RUNX3 in CD4+ T cells. This induction seems to be a prerequisite for the binding of RUNX1 and RUNX3 to three putative RUNX binding sites in the FOXP3 promoter. Inactivation of the gene encoding RUNX cofactor core-binding factor-β (CBFβ) in mice and small interfering RNA (siRNA)-mediated suppression of RUNX1 and RUNX3 in human T cells resulted in reduced expression of Foxp3. The in vivo conversion of naive CD4+ T cells into Foxp3+ iT reg cells was significantly decreased in adoptively transferred CbfbF/F CD4-cre naive T cells into Rag2−/− mice. Both RUNX1 and RUNX3 siRNA silenced human T reg cells and CbfbF/F CD4-cre mouse T reg cells showed diminished suppressive function in vitro. Circulating human CD4+ CD25high CD127− T reg cells significantly expressed higher levels of RUNX3, FOXP3, and TGF-β mRNA compared with CD4+CD25− cells. Furthermore, FOXP3 and RUNX3 were colocalized in human tonsil T reg cells. These data demonstrate Runx transcription factors as a molecular link in TGF-β–induced Foxp3 expression in iT reg cell differentiation and function.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
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Cited by
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Mechanisms of allergen-specific immunotherapy
Akdis, C. A., & Akdis, M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.030 · Cited by 803
Self-citationPeripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors
Zhu, J., & Paul, W. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00951.x · Cited by 579
Soyka, M. B., Wawrzyniak, P., Eiwegger, T., Holzmann, D., Treis, A., Wanke, K., Kast, J. I., & Akdis, C. A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.052 · Cited by 486
Metadata
- Authors
- Klunker, S., Chong, M. M. W., Mantel, P.-Y., Palomares, O., Bassin, C., Ziegler, M., Rückert, B., Meiler, F., Akdis, M., Littman, D. R., & Akdis, C. A.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-11-16
- Volume
- 206
- Issue
- 12
- Pages
- 2701-2715
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2137558988
- Cited by
- 193
- References
- 9
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Klunker, S., Chong, M. M. W., Mantel, P.-Y., Palomares, O., Bassin, C., Ziegler, M., Rückert, B., Meiler, F., Akdis, M., Littman, D. R., & Akdis, C. A. (2009). Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20090596
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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