The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
Peripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors
Open accessAbstract
Summary: CD4+ T cells, also known as T‐helper (Th) cells, play an important role in orchestrating adaptive immune responses to various infectious agents. They are also involved in the induction of autoimmune and allergic diseases. Upon T‐cell receptor (TCR)‐mediated cell activation, naive CD4+ T cells can differentiate into at least four major lineages, Th1, Th2, Th17, and iTreg cells, that participate in different types of immune responses. Networks of cytokines and transcription factors are critical for determining CD4+ T‐cell fates and effector cytokine production. Here, we review collaboration and cross‐regulation between various essential cytokines in the activation/induction of key transcription factors during the process of Th cell differentiation towards these distinct lineages. We also discuss the interactions of key transcription factors at both genetic and protein levels and the function of the resulting network(s) in regulating the expression of effector cytokines.
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Cites
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“IL-23 is important for full differentiation and maintenance of Th17 cells (36), although it is not involved in the initial differentiation stage due to lack of IL23R expression on naive CD4 T cells (8, 9, 37).”
BackgroundA Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
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Skon, C. N., Lee, J.-Y., Anderson, K. G., Masopust, D., Hogquist, K. A., & Jameson, S. C. (2013) · Nature Immunology · doi:10.1038/ni.2745 · Cited by 817
NF-κB in inflammation and cancer
Mao, H., Zhao, X., & Sun, S.-C. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 489
A cold-blooded view of adaptive immunity
Flajnik, M. F. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0003-9 · Cited by 348
Zhu, J., Jankovic, D., Oler, A. J., Wei, G., Sharma, S., Hu, G., Guo, L., Yagi, R., Yamane, H., Punkosdy, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.007 · Cited by 335
Self-citationOxidative stress in multiple sclerosis: Central and peripheral mode of action
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Metadata
- Authors
- Zhu, J., & Paul, W. E.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-10-25
- Volume
- 238
- Issue
- 1
- Pages
- 247-262
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1939125543
- Cited by
- 579
- References
- 193
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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