The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The origin and development of nonlymphoid tissue CD103+ DCs
Open accessAbstract
CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c+MHCII+ cells in tissues, which is CD103−CD11b+, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8+ DCs derive from the same precursor and follow a related differentiation program.
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Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
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Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene
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Self-citationTissue-Resident Macrophage Ontogeny and Homeostasis
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Metadata
- Authors
- Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J., Yin, N., Bromberg, J., Lira, S. A., Stanley, E. R., Nussenzweig, M., & Merad, M.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-12-14
- Volume
- 206
- Issue
- 13
- Pages
- 3115-3130
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2142084466
- Cited by
- 744
- References
- 7
- FWCI
- 20.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J., Yin, N., Bromberg, J., Lira, S. A., Stanley, E. R., Nussenzweig, M., & Merad, M. (2009). The origin and development of nonlymphoid tissue CD103+ DCs. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20091756
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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