CSF-1 regulation of the wandering macrophage: complexity in action
Abstract
Most tissue macrophages and osteoclasts are regulated by colony-stimulating factor-1 (CSF-1, also known as macrophage CSF). The effects of CSF-1 are mediated by the CSF-1 receptor tyrosine kinase (CSF-1R), through autophosphorylation of CSF-1R and the subsequent phosphorylation of downstream molecules. Triggering this phosphorylation cascade increases gene transcription and protein translation, and induces cytoskeletal remodeling by several signaling pathways, leading to the survival, proliferation and differentiation of target cells. CSF-1-regulated tissue macrophages are important for innate immunity and for tissue development and function. Because CSF-1 regulates the survival, proliferation and chemotaxis of macrophages and supports their activation, this factor is involved in the pathogenesis of several diseases.
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Microglia usually become heterogeneously distributed when they respond to an insult or stimulus.
“Microglia usually become heterogeneously distributed when they respond to an insult or stimulus [39].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [39]
The CSF-1 signaling pathway is required for microglial motility.
“Other studies have shown that the CSF-1 signaling pathway is required for microglial motility [39].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [39]
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- Authors
- Pixley, F. J., & Stanley, E. R.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Stanley, E. Richard
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 14
- Issue
- 11
- Pages
- 628-638
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2032410318
- Cited by
- 807
- References
- 98
- Citations by year
- 2026: 19 · 2025: 34 · 2024: 50 · 2023: 32 · 2022: 45 · 2021: 41 · 2020: 36 · 2019: 34 · 2018: 30 · 2017: 39 · 2016: 33 · 2015: 34 · 2014: 44 · 2013: 40 · 2012: 45
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Institutes of Health (KO8 CA097348, PO1 CA100324, RO1 CA 25604, RO1 CA32551)
- Albert Einstein Cancer Center (P30 CA13330)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- colony-stimulating factor 1, CSF-1 receptor, tissue macrophages, osteoclasts, macrophage chemotaxis, macrophage activation, signaling pathways, innate immunity, pathogenesis
- MeSH terms
- Animals, Humans, Macrophage Activation, Macrophages, Phosphorylation, Signal Transduction, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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