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Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo
Open accessAbstract
Nuclear factor interleukin-3 (Nfil3; also known as E4-binding protein 4) is a basic region leucine zipper transcription factor that has antiapoptotic activity in vitro under conditions of growth factor withdrawal. To study the role of Nfil3 in vivo, we generated gene-targeted Nfil3-deficient (Nfil3−/−) mice. Nfil3−/− mice were born at normal Mendelian frequency and were grossly normal and fertile. Although numbers of T cells, B cells, and natural killer (NK) T cells were normal in Nfil3−/− mice, a specific disruption in NK cell development resulted in severely reduced numbers of mature NK cells in the periphery. This defect was NK cell intrinsic in nature, leading to a failure to reject MHC class I–deficient cells in vivo and reductions in both interferon γ production and cytolytic activity in vitro. Our results confirm the specific and essential requirement of Nfil3 for the development of cells of the NK lineage.
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Cites
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
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Cited by
Natural Killer Cells: Development, Maturation, and Clinical Utilization
Abel, A. M., Yang, C., Thakar, M. S., & Malarkannan, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01869 · Cited by 1,150
Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells
Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. S., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.002 · Cited by 359
Tumor Necrosis Factor Superfamily in Innate Immunity and Inflammation
Šedý, J., Bekiaris, V., & Ware, C. F. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016279 · Cited by 109
Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor
Wahlestedt, M., Ladopoulos, V., Hidalgo, I., Sanchez Castillo, M., Hannah, R., Säwén, P., Wan, H., Dudenhöffer-Pfeifer, M., Magnusson, M., Norddahl, G. L., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.112 · Cited by 75
Metadata
- Authors
- Kamizono, S., Duncan, G. S., Seidel, M. G., Morimoto, A., Hamada, K., Grosveld, G., Akashi, K., Lind, E. F., Haight, J. P., Ohashi, P. S., Look, A. T., & Mak, T. W.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-12-07
- Volume
- 206
- Issue
- 13
- Pages
- 2977-2986
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2113417184
- Cited by
- 334
- References
- 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kamizono, S., Duncan, G. S., Seidel, M. G., Morimoto, A., Hamada, K., Grosveld, G., Akashi, K., Lind, E. F., Haight, J. P., Ohashi, P. S., Look, A. T., & Mak, T. W. (2009). Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20092176
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