The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity
Open accessAbstract
Sensitization to contact allergens requires activation of the innate immune system by endogenous danger signals. However, the mechanisms through which contact allergens activate innate signaling pathways are incompletely understood. In this study, we demonstrate that mice lacking the adenosine triphosphate (ATP) receptor P2X7 are resistant to contact hypersensitivity (CHS). P2X7-deficient dendritic cells fail to induce sensitization to contact allergens and do not release IL-1β in response to lipopolysaccharide (LPS) and ATP. These defects are restored by pretreatment with LPS and alum in an NLRP3- and ASC-dependent manner. Whereas pretreatment of wild-type mice with P2X7 antagonists, the ATP-degrading enzyme apyrase or IL-1 receptor antagonist, prevents CHS, IL-1β injection restores CHS in P2X7-deficient mice. Thus, P2X7 is a crucial receptor for extracellular ATP released in skin in response to contact allergens. The lack of P2X7 triggering prevents IL-1β release, which is an essential step in the sensitization process. Interference with P2X7 signaling may be a promising strategy for the prevention of allergic contact dermatitis.
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Cites
Gout-associated uric acid crystals activate the NALP3 inflammasome
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Immunological and inflammatory functions of the interleukin-1 family
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Cryopyrin activates the inflammasome in response to toxins and ATP
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The Inflammasomes: Guardians of the Body
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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
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Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
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Self-citationLiaisons dangereuses: P2X7 and the inflammasome
Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493
Cited by
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Vénéreau, E., Ceriotti, C., & Bianchi, M. E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00422 · Cited by 666
Extracellular purines, purinergic receptors and tumor growth
Di Virgilio, F., & Adinolfi, E. (2017) · Oncogene · doi:10.1038/onc.2016.206 · Cited by 559
Early immune events in the induction of allergic contact dermatitis
Kaplan, D. H., Igyártó, B. Z., & Gaspari, A. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3150 · Cited by 521
Honda, T., Egawa, G., Grabbe, S., & Kabashima, K. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.284 · Cited by 366
Martin, S. F., Esser, P. R., Weber, F. C., Jakob, T., Freudenberg, M. A., Schmidt, M., & Goebeler, M. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02652.x · Cited by 290
Self-citation
Metadata
- Authors
- Weber, F. C., Esser, P. R., Müller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., & Martin, S. F.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-11-08
- Volume
- 207
- Issue
- 12
- Pages
- 2609-2619
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2116867036
- Cited by
- 207
- References
- 12
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Weber, F. C., Esser, P. R., Müller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., & Martin, S. F. (2010). Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20092489
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