The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice
Open accessAbstract
The current epidemic of hospital- and community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections has caused significant human morbidity, but a protective vaccine is not yet available. Prior infection with S. aureus is not associated with protective immunity. This phenomenon involves staphylococcal protein A (SpA), an S. aureus surface molecule that binds to Fcγ of immunoglobulin (Ig) and to the Fab portion of VH3-type B cell receptors, thereby interfering with opsonophagocytic clearance of the pathogen and ablating adaptive immune responses. We show that mutation of each of the five Ig-binding domains of SpA with amino acid substitutions abolished the ability of the resulting variant SpAKKAA to bind Fcγ or Fab VH3 and promote B cell apoptosis. Immunization of mice with SpAKKAA raised antibodies that blocked the virulence of staphylococci, promoted opsonophagocytic clearance, and protected mice against challenge with highly virulent MRSA strains. Furthermore, SpAKKAA immunization enabled MRSA-challenged mice to mount antibody responses to many different staphylococcal antigens.
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Citations
Cites
1 retracted
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
Cheng, A. G., Kim, H. K., Burts, M. L., Krausz, T., Schneewind, O., & Missiakas, D. M. (2009) · The FASEB Journal · doi:10.1096/fj.09-135467 · Cited by 437
Self-citationRetractedKlevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726
Infection with Vancomycin-Resistant Staphylococcus aureus Containing the vanA Resistance Gene
Chang, S., Sievert, D. M., Hageman, J. C., Boulton, M. L., Tenover, F. C., Downes, F. P., Shah, S., Rudrik, J. T., Pupp, G. R., Brown, W. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025025 · Cited by 1,095
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
Mazmanian, S. K., Liu, G., Ton-That, H., & Schneewind, O. (1999) · Science · doi:10.1126/science.285.5428.760 · Cited by 1,053
Self-citationTon-That, H., Liu, G., Mazmanian, S. K., Faull, K. F., & Schneewind, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12424 · Cited by 567
Self-citationSorting of protein a to the staphylococcal cell wall
Schneewind, O., Model, P., & Fischetti, V. A. (1992) · Cell · doi:10.1016/0092-8674(92)90101-h · Cited by 552
Self-citationStaphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Gómez, M. I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., Cheung, A., & Prince, A. (2004) · Nature Medicine · doi:10.1038/nm1079 · Cited by 412
Protein A Isolated from Staphylococcus aureus after Digestion with Lysostaphin
Sjöquist, J., Meloun, B., & Hjelm, H. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb02023.x · Cited by 308 · cited 2×
“Using these models and molecular genetics approaches, staphylococcal protein A (SpA), a cell wall–anchored surface protein (Sjöquist et al., 1972), was identified as a crucial virulence factor for lung infections, septicemia, and abscess development (Palmqvist et al.”
MethodKuklin, N. A., Clark, D. J., Secore, S., Cook, J., Cope, L. D., McNeely, T., Noble, L., Brown, M. J., Zorman, J. K., Wang, X. M., et al. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2215-2223.2006 · Cited by 264
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Cited by
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,533
Staphylococcus aureus biofilms: Properties, regulation, and roles in human disease
Archer, N. K., Mazaitis, M. J., Costerton, J. W., Leid, J. G., Powers, M. E., & Shirtliff, M. E. (2011) · Virulence · doi:10.4161/viru.2.5.17724 · Cited by 1,018
Staphylococcus aureus Secreted Toxins and Extracellular Enzymes
Tam, K., & Torres, V. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0039-2018 · Cited by 452
Immunity against Staphylococcus aureus cutaneous infections
Miller, L. S., & Cho, J. S. (2011) · Nature Reviews Immunology · doi:10.1038/nri3010 · Cited by 434
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng, A. G., McAdow, M., Kim, H. K., Bae, T., Missiakas, D. M., & Schneewind, O. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001036 · Cited by 324
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Metadata
- Authors
- Kim, H. K., Cheng, A. G., Kim, H.-Y., Missiakas, D. M., & Schneewind, O.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-08-16
- Volume
- 207
- Issue
- 9
- Pages
- 1863-1870
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2069699883
- Cited by
- 203
- References
- 11
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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