Panton‐Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community‐Associated Methicillin‐Resistant Staphylococcus aureus Disease
Open accessAbstract
Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other virulence factors that are common in these clones are likely responsible for the mouse phenotype.
“Since PVL seems to have few effects on virulence in both primary and secondary mouse pneumonia models [22,50], other virulence factors that are common in these clones are likely responsible for the mouse phenotype.”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lina, G., Piemont, Y., Godail-Gamot, F., Bes, M., Peter, M.-O., Gauduchon, V., Vandenesch, F., & Etienne, J. (1999) · Clinical Infectious Diseases · doi:10.1086/313461 · Cited by 2,489 · see citing works
Methicillin-Resistant <i>S. aureus</i> Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285 · see citing works
Vandenesch, F., Naimi, T. S., Enright, M. C., Lina, G., Nimmo, G. R., Heffernan, H., Liassine, N., Bes, M., Greenland, T., Reverdy, M. E., et al. (2003) · Emerging infectious diseases · doi:10.3201/eid0908.030089 · Cited by 1,718 · see citing works
Diep, B. A., Gill, S. R., Chang, R. F., Phan, T. H., Chen, J. H., Davidson, M. G., Lin, F., Lin, J., Carleton, H. A., Mongodin, E. F., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68231-7 · Cited by 1,633 · see citing works
Gillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514 · see citing works
Genome and virulence determinants of high virulence community-acquired MRSA
Baba, T., Takeuchi, F., Kuroda, M., Yuzawa, H., Aoki, K.-I., Oguchi, A., Nagai, Y., Iwama, N., Asano, K., Naimi, T. S., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08713-5 · Cited by 1,356 · see citing works
King, M. D., Humphrey, B. J., Wang, Y. F., Kourbatova, E. V., Ray, S. M., & Blumberg, H. M. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-5-200603070-00005 · Cited by 776 · see citing works
Francis, J. S., Doherty, M. C., Lopatin, U. A., Johnston, C. P., Sinha, G., Ross, T. L., Cai, M., Hansel, N. N., Perl, T. M., Ticehurst, J. R., et al. (2004) · Clinical Infectious Diseases · doi:10.1086/427148 · Cited by 715 · see citing works
Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia
Labandeira‐Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., Barbu, E. M., Sarathy, V. V., Höök, M., Étienne, J., et al. (2007) · Science · doi:10.1126/science.1137165 · Cited by 707 · see citing works
Voyich, J. M., Otto, M. J., Mathema, B., Braughton, K. R., Whitney, A. R., Welty, D. M., Long, R. D., Dorward, D. W., Gardner, D. J., Lina, G., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/509506 · Cited by 562 · see citing works
Self-citationPoring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F. R., & Schneewind, O. (2007) · Nature Medicine · doi:10.1038/nm1207-1405 · Cited by 492 · see citing works
Self-citationSevere Community-acquired Pneumonia Due to <i>Staphylococcus aureus</i> , 2003–04 Influenza Season
Hageman, J. C., Uyeki, T. M., Francis, J. S., Jernigan, D. B., Wheeler, J. G., Bridges, C. B., Barenkamp, S. J., Sievert, D. M., Srinivasan, A., Doherty, M. C., et al. (2006) · Emerging infectious diseases · doi:10.3201/eid1206.051141 · Cited by 379 · see citing works
Wardenburg, J. B., Patel, R. J., & Schneewind, O. (2007) · Infection and Immunity · doi:10.1128/iai.01313-06 · Cited by 348 · see citing works
Self-citationKönig, B., Prévost, G., Piémont, Y., & König, W. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.3.607 · Cited by 164 · see citing works
Miles, G., Movileanu, L., & Bayley, H. (2002) · Protein Science · doi:10.1110/ps.4360102 · Cited by 123 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718 · see citing works
Self-citationDavid, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972 · see citing works
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,697 · see citing works
Community-associated meticillin-resistant Staphylococcus aureus
DeLeo, F. R., Otto, M. J., Kreiswirth, B. N., & Chambers, H. F. “. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61999-1 · Cited by 1,502 · see citing works
Self-citationStaphylococcal manipulation of host immune responses
Thammavongsa, V., Kim, H. K., Missiakas, D. M., & Schneewind, O. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3521 · Cited by 594 · see citing works
Self-citationStaphylococcal and Streptococcal Superantigen Exotoxins
Spaulding, A. R., Salgado‐Pabón, W., Kohler, P. L., Horswill, A. R., Leung, D. Y. M., & Schlievert, P. M. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00104-12 · Cited by 540 · see citing works
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
DeLeo, F. R., & Chambers, H. F. “. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38226 · Cited by 509 · see citing works
Self-citationShallcross, L. J., Fragaszy, E., Johnson, A. M., & Hayward, A. C. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70238-4 · Cited by 462 · see citing works
Basis of Virulence in Community-Associated Methicillin-Resistant <i>Staphylococcus aureus</i>
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457 · see citing works
Self-citationLöffler, B., Hussain, M., Grundmeier, M., Brück, M., Holzinger, D., Varga, G., Roth, J., Kahl, B. C., Proctor, R. A., & Peters, G. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000715 · Cited by 440 · see citing works
Vandenesch, F., Lina, G., & Henry, T. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00012 · Cited by 405 · see citing works
Neutrophils in innate host defense against Staphylococcus aureus infections
Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400 · see citing works
Self-citationLi, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394 · see citing works
Self-citationStaphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments
Ahmad-Mansour, N., Loubet, P., Pouget, C., Dunyach‐Remy, C., Sotto, A., Lavigne, J., & Molle, V. (2021) · Toxins · doi:10.3390/toxins13100677 · Cited by 406 · see citing works
Community-associated MRSA: What makes them special?
Otto, M. (2013) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2013.02.007 · Cited by 379 · see citing works
Self-citationLeukocidins: staphylococcal bi-component pore-forming toxins find their receptors
Spaan, A. N., van Strijp, J. A. G., & Torres, V. J. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.27 · Cited by 354 · see citing works
Diep, B. A., Chan, L., Tattevin, P., Kajikawa, O., Martin, T. R., Basuino, L., Mai, T. T., Marbach, H., Braughton, K. R., Whitney, A. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912403107 · Cited by 347 · see citing works
Self-citationKennedy, A. D., Wardenburg, J. B., Gardner, D. J., Long, D., Whitney, A. R., Braughton, K. R., Schneewind, O., & DeLeo, F. R. (2010) · The Journal of Infectious Diseases · doi:10.1086/656043 · Cited by 335 · see citing works
Self-citationThe role of virulence determinants in community-associated MRSA pathogenesis
Diep, B. A., & Otto, M. J. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.05.002 · Cited by 329 · see citing works
Self-citationCheung, G. Y. C., Wang, R., Khan, B. A., Sturdevant, D. E., & Otto, M. J. (2011) · Infection and Immunity · doi:10.1128/iai.00046-11 · Cited by 317 · see citing works
Self-citationThe Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
Alonzo, F., & Torres, V. J. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-13 · Cited by 276 · see citing works
Host defense and pathogenesis in Staphylococcus aureus infections
DeLeo, F. R., Diep, B. A., & Otto, M. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2008.10.003 · Cited by 269 · see citing works
“aureus strain Newman, no significant contribution of PVL to lethal pneumonia was found [88,89].”
BackgroundSelf-citationKobayashi, S. D., Małachowa, N., Whitney, A. R., Braughton, K. R., Gardner, D. J., Long, D., Wardenburg, J. B., Schneewind, O., Otto, M. J., & DeLeo, F. R. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir441 · Cited by 266 · see citing works
Self-citationPrevention and treatment of Staphylococcus aureus biofilms
Bhattacharya, M., Wozniak, D. J., Stoodley, P., & Hall‐Stoodley, L. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1100533 · Cited by 271 · see citing works
Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureus
vanBelkum, A. F., Melles∗, D. C., Nouwen, J. L., vanLeeuwen, W. B., van Wamel, W. J. B., Vos, M. D., Wertheim, H. F. L., & Verbrugh, H. A. (2008) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2008.09.012 · Cited by 251 · see citing works
Miller, L. S., Fowler, V. G., Shukla, S. K., Rose, W. E., & Proctor, R. A. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz030 · Cited by 237 · see citing works
Staphylococcus aureus toxins – Their functions and genetics
Grumann, D., Nübel, U., & Bröker, B. M. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.03.013 · Cited by 234 · see citing works
Global Changes in Staphylococcus aureus Gene Expression in Human Blood
Małachowa, N., Whitney, A. R., Kobayashi, S. D., Sturdevant, D. E., Kennedy, A. D., Braughton, K. R., Shabb, D. W., Diep, B. A., Chambers, H. F. “., Otto, M. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018617 · Cited by 226 · see citing works
Self-citationMolecular Pathogenesis of Staphylococcus aureus Infection
Liu, G. Y. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819dc44d · Cited by 218 · see citing works
Methicillin-resistantStaphylococcus aureus(MRSA) in food production animals
Vanderhaeghen, W., Hermans, K., Haesebrouck, F., & Butaye, P. (2010) · Epidemiology and Infection · doi:10.1017/s0950268809991567 · Cited by 218 · see citing works
Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity
Seilie, E. S., & Wardenburg, J. B. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.04.003 · Cited by 206 · see citing works
Self-citationNontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice
Kim, H. K., Cheng, A. G., Kim, H., Missiakas, D. M., & Schneewind, O. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092514 · Cited by 203 · see citing works
Self-citationThurlow, L. R., Joshi, G. S., Clark, J. R., Spontak, J. S., Neely, C. J., Maile, R., & Richardson, A. R. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2012.11.012 · Cited by 203 · see citing works
Importance of the Global Regulators Agr and SaeRS in the Pathogenesis of CA-MRSA USA300 Infection
Montgomery, C. P., Boyle‐Vavra, S., & Daum, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015177 · Cited by 198 · see citing works
Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin
Scherr, T. D., Hanke, M. L., Huang, O., James, D. B. A., Horswill, A. R., Bayles, K. W., Fey, P. D., Torres, V. J., & Kielian, T. (2015) · mBio · doi:10.1128/mbio.01021-15 · Cited by 195 · see citing works
Schlievert, P. M., Strandberg, K. L., Lin, Y., Peterson, M. L., & Leung, D. Y. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.039 · Cited by 193 · see citing works
Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis
Surewaard, B. G. J., de Haas, C. J. C., Vervoort, F., Rigby, K. M., DeLeo, F. R., Otto, M. J., van Strijp, J. A. G., & Nijland, R. (2013) · Cellular Microbiology · doi:10.1111/cmi.12130 · Cited by 190 · see citing works
Self-citationDiep, B. A., Palazzolo‐Ballance, A. M., Tattevin, P., Basuino, L., Braughton, K. R., Whitney, A. R., Chen, L., Kreiswirth, B. N., Otto, M. J., DeLeo, F. R., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003198 · Cited by 184 · see citing works
Self-citationCurrent concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus
Watkins, R., David, M. Z., & Salata, R. A. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.043513-0 · Cited by 177 · see citing works
Li, M., Cheung, G. Y. C., Hu, J., Wang, D., Joo, H., DeLeo, F. R., & Otto, M. (2010) · The Journal of Infectious Diseases · doi:10.1086/657419 · Cited by 175 · see citing works
Self-citationBień, J., Sokolova, O. V., & Bozko, P. M. (2011) · Journal of Pathogens · doi:10.4061/2011/601905 · Cited by 176 · see citing works
Influenza virus primes mice for pneumonia from Staphylococcus aureus.
Iverson, A. R., Boyd, K. L., McAuley, J. L., Plano, L. R., Hart, M. E., & McCullers, J. A. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq113 · Cited by 168 · see citing works
Thurlow, L. R., Joshi, G. S., & Richardson, A. R. (2012) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2012.00937.x · Cited by 163 · see citing works
SaeR Binds a Consensus Sequence within Virulence Gene Promoters to Advance USA300 Pathogenesis
Nygaard, T. K., Pallister, K. B., Ruzevich, P., Griffith, S., Vuong, C., & Voyich, J. M. (2009) · The Journal of Infectious Diseases · doi:10.1086/649570 · Cited by 157 · see citing works
Brown, E. L., Dumitrescu, O., Thomas, D. Y., Badiou, C., Koers, E. M., Choudhury, P., Vazquez, V., Étienne, J., Lina, G., Vandenesch, F., et al. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02648.x · Cited by 162 · see citing works
Yamamoto, T., Nishiyama, A., Takano, T., Yabe, S., Higuchi, W., Razvina, O., & Shi, D. (2010) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-010-0045-9 · Cited by 151 · see citing works
Adhikari, R. P., Ajao, A. O., Aman, M. J., Karaüzüm, H., Sarwar, J., Lydecker, A. D., Johnson, J. K., Nguyen, C., Chen, W. H., & Roghmann, M. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis462 · Cited by 144 · see citing works
Wacker, M., Wang, L., Kowarik, M., Dowd, M., Lipowsky, G., Faridmoayer, A., Shields, K., Park, S., Alaimo, C., Kelley, K. A., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit800 · Cited by 137 · see citing works
Melehani, J. H., James, D. B. A., Dumont, A., Torres, V. J., & Duncan, J. A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004970 · Cited by 130 · see citing works
Crémieux, A., Dumitrescu, O., Lina, G., Vallée, C. A., Côté, J.-F., Muffat‐Joly, M., Lilin, T., Étienne, J., Vandenesch, F., & Saleh‐Mghir, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007204 · Cited by 127 · see citing works
Perret, M., Badiou, C., Lina, G., Burbaud, S., Benito, Y., Bes, M., Cottin, V., Couzon, F., Juruj, C., Dauwalder, O., et al. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01772.x · Cited by 116 · see citing works
Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids
Dumont, A., & Torres, V. J. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.10.004 · Cited by 113 · see citing works
Persistent Staphylococcus aureus Bacteremia
Chong, Y. P., Park, S., Kim, H. S., Kim, E. S., Kim, M., Park, K., Kim, S., Lee, S., Choi, S., Jeong, J., et al. (2013) · Medicine · doi:10.1097/md.0b013e318289ff1e · Cited by 107 · see citing works
Wall teichoic acids mediate increased virulence in Staphylococcus aureus
Wanner, S., Schade, J., Keinhörster, D., Weller, N., George, S. E., Kull, L., Bauer, J., Grau, T., Winstel, V., Stoy, H., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.257 · Cited by 104 · see citing works
Tseng, C. W., Kyme, P. A., Low, J., Rocha, M. A., Alsabeh, R., Miller, L. G., Otto, M. J., Arditi, M., Diep, B. A., Nizet, V., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006387 · Cited by 102 · see citing works
Self-citationLipinska, U., Hermans, K., Meulemans, L., Dumitrescu, O., Badiou, C., Duchateau, L., Haesebrouck, F., Etienne, J., & Lina, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022864 · Cited by 100 · see citing works
Bae, I., Tonthat, G. T., Stryjewski, M. E., Rude, T. H., Reilly, L. F., Barriere, S. L., Genter, F. C., Corey, G. R., & Fowler, V. G. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.01643-09 · Cited by 99 · see citing works
Tong, S. Y. C., Chen, L. F., & Fowler, V. G. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0300-x · Cited by 97 · see citing works
Rauch, S., DeDent, A. C., Kim, H. K., Wardenburg, J. B., Missiakas, D. M., & Schneewind, O. (2012) · Infection and Immunity · doi:10.1128/iai.00442-12 · Cited by 93 · see citing works
Self-citationThe role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections
Yamazaki, Y., Ito, T., Tamai, M., Nakagawa, S., & Nakamura, Y. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00323-8 · Cited by 97 · see citing works
Methicillin-Resistant Staphylococcus aureus Infection and Treatment Options
Chalmers, S. J., & Wylam, M. E. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9849-4_16 · Cited by 91 · see citing works
Chua, K., Seemann, T., Harrison, P. F., Monagle, S., Korman, T. M., Johnson, P. D. R., Coombs, G. W., Howden, B. O., Davies, J. K., Howden, B. P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025887 · Cited by 91 · see citing works
Staphylococcus aureus Leukotoxin GH Promotes Inflammation
Małachowa, N., Kobayashi, S. D., Braughton, K. R., Whitney, A. R., Parnell, M. J., Gardner, D. J., & DeLeo, F. R. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis495 · Cited by 91 · see citing works
Self-citationBoakes, E., Kearns, A., Ganner, M., Perry, C., Hill, R. L., & Ellington, M. J. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01917-10 · Cited by 87 · see citing works
Eisele, N. A., & Anderson, D. M. (2011) · Journal of Pathogens · doi:10.4061/2011/249802 · Cited by 88 · see citing works
Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages
Jiang, J., Cameron, D. R., Nethercott, C., Aires-de-Sousa, M., & Peleg, A. Y. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00148-22 · Cited by 89 · see citing works
Schwartz, J., Leidal, K. G., Femling, J., Weiss, J. P., & Nauseef, W. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804110 · Cited by 86 · see citing works
Villaruz, A. E., Wardenburg, J. B., Khan, B. A., Whitney, A. R., Sturdevant, D. E., Gardner, D. J., DeLeo, F. R., & Otto, M. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/604728 · Cited by 84 · see citing works
Self-citationNovel targeted immunotherapy approaches for staphylococcal infection
Otto, M. J. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2010.495115 · Cited by 84 · see citing works
Self-citationUSA300 is the Predominant Genotype Causing Staphylococcus aureus Septic Arthritis in Children
Carrillo-Marquez, M. A., Hultén, K. G., Hammerman, W. A., Mason, E. O., & Kaplan, S. L. (2009) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181adbcfe · Cited by 82 · see citing works
Characterization of a Mouse-Adapted Staphylococcus aureus Strain
Holtfreter, S., Radcliff, F. J., Grumann, D., Read, H. M., Johnson, S., Monecke, S., Ritchie, S. R., Clow, F., Goerke, C., Bröker, B. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071142 · Cited by 79 · see citing works
An update on community-associated MRSA virulence
Kobayashi, S. D., & DeLeo, F. R. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.07.009 · Cited by 78 · see citing works
Self-citationRecurrent furunculosis: a review of the literature
Demos, M., McLeod, M. P., & Nouri, K. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11151.x · Cited by 79 · see citing works
Löffler, B., Niemann, S., Ehrhardt, C., Horn, D., Lanckohr, C., Lina, G., Ludwig, S., & Peters, G. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2013.827891 · Cited by 79 · see citing works
Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence
Graves, S. F., Kobayashi, S. D., & DeLeo, F. R. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0573-x · Cited by 76 · see citing works
Self-citationTong, S. Y. C., Lilliebridge, R. A., Bishop, E. J., Cheng, A. C., Holt, D. C., McDonald, M., Giffard, P. M., Currie, B. J., & Boutlis, C. S. (2010) · The Journal of Infectious Diseases · doi:10.1086/655396 · Cited by 75 · see citing works
Montgomery, C. P., Boyle‐Vavra, S., & Daum, R. S. (2009) · Infection and Immunity · doi:10.1128/iai.00256-09 · Cited by 72 · see citing works
Yoong, P., & Pier, G. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910344107 · Cited by 73 · see citing works
Cho, J. S., Zussman, J., Donegan, N. P., Ramos, R. I., Garcia, N. C., Uslan, D. Z., Iwakura, Y., Simon, S. I., Cheung, A. L., Modlin, R. L., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.417 · Cited by 72 · see citing works
Impact of sarA on Daptomycin Susceptibility of Staphylococcus aureus Biofilms In Vivo
Weiss, E. C., Zielinska, A., Beenken, K. E., Spencer, H. J., Daily, S. T., & Smeltzer, M. S. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00484-09 · Cited by 70 · see citing works
Montgomery, C. P., & Daum, R. S. (2009) · Infection and Immunity · doi:10.1128/iai.00021-09 · Cited by 67 · see citing works
Hermos, C., Yoong, P., & Pier, G. B. (2010) · Clinical Infectious Diseases · doi:10.1086/656742 · Cited by 67 · see citing works
Gonzalez, D. J., Okumura, C. Y. M., Hollands, A., Kersten, R. D., Akong, K., Pence, M. A., Malone, C. L., Derieux, J., Moore, B. S., Horswill, A. R., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349860 · Cited by 65 · see citing works
Chi, C., Lin, C., Liao, I., Yao, Y., Shen, F.-C., Liu, H., & Lin, C. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit445 · Cited by 65 · see citing works
Quorum Sensing and Toxin Production in Staphylococcus aureus Osteomyelitis: Pathogenesis and Paradox
Butrico, C. E., & Cassat, J. E. (2020) · Toxins · doi:10.3390/toxins12080516 · Cited by 64 · see citing works
The rise and rise ofStaphylococcus aureus: laughing in the face of granulocytes
Anwar, S., Prince, L. R., Foster, S. J., Whyte, M. K. B., & Sabroe, I. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03950.x · Cited by 64 · see citing works
Population Structure of Staphylococcus aureus from Remote African Babongo Pygmies
Schaumburg, F., Köck, R., Friedrich, A. W., Soulanoudjingar, S., Ngoa, U. A., von Eiff, C., Issifou, S., Kremsner, P. G., Herrmann, M., Peters, G., et al. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001150 · Cited by 62 · see citing works
Immunotherapeutic strategies to combat staphylococcal infections
Ohlsen, K., & Lorenz, U. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.04.015 · Cited by 61 · see citing works
Humanized Mice Exhibit Increased Susceptibility to Staphylococcus aureus Pneumonia
Prince, A. S., Wang, H., Kitur, K., & Parker, D. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw425 · Cited by 60 · see citing works
Wirtz, C., Witte, W., Wolz, C., & Goerke, C. (2009) · Microbiology · doi:10.1099/mic.0.032466-0 · Cited by 60 · see citing works
Montgomery, C. P., Boyle‐Vavra, S., Roux, A., Ebine, K., Sonenshein, A. L., & Daum, R. S. (2012) · Infection and Immunity · doi:10.1128/iai.06172-11 · Cited by 59 · see citing works
Kreienbühl, L., Charbonney, E., & Eggimann, P. (2011) · Annals of Intensive Care · doi:10.1186/2110-5820-1-52 · Cited by 61 · see citing works
Giudice, P. D., Blanc, V., de Rougemont, A., Bes, M., Lina, G., Hubiche, T., Roudière, L., Vandenesch, F., & Étienne, J. (2009) · Dermatology · doi:10.1159/000232391 · Cited by 57 · see citing works
New insights into the prevention of staphylococcal infections and toxic shock syndrome
Lin, Y., & Peterson, M. L. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.121 · Cited by 57 · see citing works
Masiuk, H., Kopron, K., Grumann, D., Goerke, C., Kolata, J., Jursa-Kulesza, J., Giedrys‐Kalemba, S., Bröker, B. M., & Holtfreter, S. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02094-09 · Cited by 55 · see citing works
Shambat, S. M., Chen, P., Hoang, A. T. N., Bergsten, H., Vandenesch, F., Siemens, N., Lina, G., Monk, I. R., Foster, T. J., Arakere, G., et al. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.021923 · Cited by 52 · see citing works
A MRSA-terious enemy among us: End of the PVL controversy?
Otto, M. J. (2011) · Nature Medicine · doi:10.1038/nm0211-169 · Cited by 51 · see citing works
Self-citationChua, K., Monk, I. R., Lin, Y.-H., Seemann, T., Tuck, K. L., Porter, J. L., Stepnell, J., Coombs, G. W., Davies, J. K., Stinear, T. P., et al. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-31 · Cited by 52 · see citing works
Yoong, P., & Pier, G. B. (2012) · Infection and Immunity · doi:10.1128/iai.06360-11 · Cited by 52 · see citing works
Thabit, A. K., Crandon, J. L., & Nicolau, D. P. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.08.012 · Cited by 50 · see citing works
- Authors
- Wardenburg, J. B., Palazzolo‐Ballance, A. M., Otto, M., Schneewind, O., & DeLeo, F. R.
- Affiliations
- University of Chicago (US)
- National Institute of Allergy and Infectious Diseases (US)
- Corresponding author
- Schneewind, Olaf
- DeLeo, Frank R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-15
- Volume
- 198
- Issue
- 8
- Pages
- 1166-1170
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC2574921
- OpenAlex
- W2151524578
- Cited by
- 236
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 11 · 2015: 12 · 2014: 13 · 2013: 28 · 2012: 17
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1r41ai052747-01)
- National Institute of Allergy and Infectious Diseases (Z01AI000900, AI52747, R01AI052474)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K-12-HD 00850, K12HD000850)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Panton-Valentine leukocidin, community-associated methicillin-resistant Staphylococcus aureus, virulence factors, USA300, staphylococcal skin infections, staphylococcal pneumonia, mouse infection model, BALB/c mice, pathogenesis
- MeSH terms
- Animals, Bacterial Toxins, Disease Models, Animal, Exotoxins, Female, Humans, Leukocidins, Mice, Inbred BALB C, Mutation, Pneumonia, Staphylococcal, Staphylococcal Skin Infections, Staphylococcus aureus, Virulence, Methicillin Resistance, Community-Acquired Infections, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
