The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
Open accessAbstract
It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI+ DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.
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Cites
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Cited by
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Self-citationBarrier Epithelial Cells and the Control of Type 2 Immunity
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Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation
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Metadata
- Authors
- Hammad, H., Plantinga, M., Deswarte, K., Pouliot, P., Willart, M. A. M., Kool, M., Muskens, F., & Lambrecht, B. N.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-09-06
- Volume
- 207
- Issue
- 10
- Pages
- 2097-2111
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2121853472
- Cited by
- 630
- References
- 66
- FWCI
- 37.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Hammad, H., Plantinga, M., Deswarte, K., Pouliot, P., Willart, M. A. M., Kool, M., Muskens, F., & Lambrecht, B. N. (2010). Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20101563
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