The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cutaneous immunosurveillance by self-renewing dermal γδ T cells
Open accessAbstract
The presence of γδ T cell receptor (TCR)–expressing cells in the epidermis of mice, termed dendritic epidermal T cells (DETCs), is well established. Because of their strict epidermal localization, it is likely that DETCs primarily respond to epithelial stress, such as infections or the presence of transformed cells, whereas they may not participate directly in dermal immune responses. In this study, we describe a prominent population of resident dermal γδ T cells, which differ from DETCs in TCR usage, phenotype, and migratory behavior. Dermal γδ T cells are radioresistant, cycle in situ, and are partially depend on interleukin (IL)-7, but not IL-15, for their development and survival. During mycobacterial infection, dermal γδ T cells are the predominant dermal cells that produce IL-17. Absence of dermal γδ T cells is associated with decreased expansion in skin draining lymph nodes of CD4+ T cells specific for an immunodominant Mycobacterium tuberculosis epitope. Decreased CD4+ T cell expansion is related to a reduction in neutrophil recruitment to the skin and decreased BCG shuttling to draining lymph nodes. Thus, dermal γδ T cells are an important part of the resident cutaneous immunosurveillance program. Our data demonstrate functional specialization of T cells in distinct microcompartments of the skin.
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Cites
γδ T cell effector functions: a blend of innate programming and acquired plasticity
Bonneville, M., O'Brien, R. L., & Born, W. K. (2010) · Nature Reviews Immunology · doi:10.1038/nri2781 · Cited by 952
γδ T cells: functional plasticity and heterogeneity
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Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor.
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Cited by
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261
Compartmentalized Control of Skin Immunity by Resident Commensals
Naik, S., Bouladoux, N., Wilhelm, C., Molloy, M. J., Salcedo, R., Kastenmuller, W., Deming, C., Quinones, M., Koo, L., Conlan, S., et al. (2012) · Science · doi:10.1126/science.1225152 · Cited by 1,092
The emerging role of resident memory T cells in protective immunity and inflammatory disease
Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 517
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Antigen-Presenting Cells in the Skin
Kashem, S. W., Haniffa, M., & Kaplan, D. H. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052215 · Cited by 361
Metadata
- Authors
- Sumaria, N., Roediger, B., Ng, L. G., Qin, J., Pinto, R., Cavanagh, L. L., Shklovskaya, E., Fazekas de St. Groth, B., Triccas, J. A., & Weninger, W.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-02-21
- Volume
- 208
- Issue
- 3
- Pages
- 505-518
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2137130743
- Cited by
- 280
- References
- 9
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Sumaria, N., Roediger, B., Ng, L. G., Qin, J., Pinto, R., Cavanagh, L. L., Shklovskaya, E., Fazekas de St. Groth, B., Triccas, J. A., & Weninger, W. (2011). Cutaneous immunosurveillance by self-renewing dermal γδ T cells. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20101824
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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