The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region
Open accessAbstract
Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Little is known about the embryonic development of human HSCs. We demonstrate that human HSCs emerge first in the aorta-gonad-mesonephros (AGM) region, specifically in the dorsal aorta, and only later appear in the yolk sac, liver, and placenta. AGM region cells transplanted into immunodeficient mice provide long-term high level multilineage hematopoietic repopulation. Human AGM region HSCs, although present in low numbers, exhibit a very high self-renewal potential. A single HSC derived from the AGM region generates at least 300 daughter HSCs in primary recipients, which disseminate throughout the entire recipient bone marrow and are retransplantable. These findings highlight the vast regenerative potential of the earliest human HSCs and set a new standard for in vitro generation of HSCs from pluripotent stem cells for the purpose of regenerative medicine.
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1 retracted
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Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice
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Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment
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Cited by
Unique aspects of the perinatal immune system
Zhang, X., Zhivaki, D., & Lo-Man, R. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.54 · Cited by 276
The hematopoietic stem cell niche: from embryo to adult
Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development · doi:10.1242/dev.139691 · Cited by 247
Haematopoietic stem cell self-renewal in vivo and ex vivo
Wilkinson, A. C., Igarashi, K. J., & Nakauchi, H. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0241-0 · Cited by 226
Buchrieser, J., James, W., & Moore, M. D. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.12.020 · Cited by 215
The embryonic origins of erythropoiesis in mammals
Baron, M. H., Isern, J., & Fraser, S. T. (2012) · Blood · doi:10.1182/blood-2012-01-153486 · Cited by 209
Metadata
- Authors
- Ivanovs, A., Rybtsov, S., Welch, L., Anderson, R. A., Turner, M. L., & Medvinsky, A.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-10-31
- Volume
- 208
- Issue
- 12
- Pages
- 2417-2427
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2115864156
- Cited by
- 286
- References
- 54
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ivanovs, A., Rybtsov, S., Welch, L., Anderson, R. A., Turner, M. L., & Medvinsky, A. (2011). Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20111688
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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