The embryonic origins of erythropoiesis in mammals
Abstract
Erythroid (red blood) cells are the first cell type to be specified in the postimplantation mammalian embryo and serve highly specialized, essential functions throughout gestation and postnatal life. The existence of 2 developmentally and morphologically distinct erythroid lineages, primitive (embryonic) and definitive (adult), was described for the mammalian embryo more than a century ago. Cells of the primitive erythroid lineage support the transition from rapidly growing embryo to fetus, whereas definitive erythrocytes function during the transition from fetal life to birth and continue to be crucial for a variety of normal physiologic processes. Over the past few years, it has become apparent that the ontogeny and maturation of these lineages are more complex than previously appreciated. In this review, we highlight some common and distinguishing features of the red blood cell lineages and summarize advances in our understanding of how these cells develop and differentiate throughout mammalian ontogeny.
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The model accurately predicted the hematopoietic composition of the organ, known to shift from the liver at embryonic stages to the bone marrow in adulthood, rather than the tissue type itself.
“Strikingly, in this case, our model accurately predicted the hematopoietic composition of the organ, known to shift from the liver at the embryonic stages to the bone marrow in adulthood (64), rather than the tissue type itself.”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [64]
Cites
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Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science · doi:10.1126/science.aad3312 · Cited by 373 · see citing works
A mouse tissue atlas of small noncoding RNA
Isakova, A., Fehlmann, T., Keller, A., & Quake, S. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002277117 · Cited by 119 · see citing works
Spatial transcriptome sequencing of FFPE tissues at cellular level
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- Authors
- Baron, M. H., Isern, J., & Fraser, S. T.
- Affiliations
- Departments of Medicine,
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-05-24
- Volume
- 119
- Issue
- 21
- Pages
- 4828-4837
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 185
- References
- 7
- Language
- en
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