The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Open accessAbstract
Despite a growing understanding of the link between intestinal inflammation and resident gut microbes, longitudinal studies of human flora before initial onset of intestinal inflammation have not been reported. Here, we demonstrate in murine and human recipients of allogeneic bone marrow transplantation (BMT) that intestinal inflammation secondary to graft-versus-host disease (GVHD) is associated with major shifts in the composition of the intestinal microbiota. The microbiota, in turn, can modulate the severity of intestinal inflammation. In mouse models of GVHD, we observed loss of overall diversity and expansion of Lactobacillales and loss of Clostridiales. Eliminating Lactobacillales from the flora of mice before BMT aggravated GVHD, whereas reintroducing the predominant species of Lactobacillus mediated significant protection against GVHD. We then characterized gut flora of patients during onset of intestinal inflammation caused by GVHD and found patterns mirroring those in mice. We also identified increased microbial chaos early after allogeneic BMT as a potential risk factor for subsequent GVHD. Together, these data demonstrate regulation of flora by intestinal inflammation and suggest that flora manipulation may reduce intestinal inflammation and improve outcomes for allogeneic BMT recipients.
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“Preclinical models have shown that commensal bacteria influence the pathophysiology of GVHD.10,17–20”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [19]
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“The onset of acute-GVHD is associated with significant shifts in the composition of the microbiota with a loss of overall diversity and reduction of health-promoting obligate anaerobes such as Faecalibacterium, Ruminococcus, Lactobacillus, and Blautia, and an enrichment of Enterococcus and Clostridiales”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Jenq et al., 2012
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Metadata
- Authors
- Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., Gobourne, A., Lipuma, L., Young, L. F., Smith, O. M., Ghosh, A., Hanash, A. M., Goldberg, J. D., Aoyama, K., Blazar, B. R., Pamer, E. G., & R.M. van den Brink, M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Adult Bone Marrow Transplantation Service 1 and 2 ; and 3
- Cornell University (US)
- University of Florida (US)
- University of Minnesota (US)
- Corresponding author
- Jenq, Robert R.
- ORCID
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2012-04-30
- Volume
- 209
- Issue
- 5
- Pages
- 903-911
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC3348096
- OpenAlex
- W2131766513
- Cited by
- 626
- References
- 37
- Citations by year
- 2026: 15 · 2025: 35 · 2024: 23 · 2023: 45 · 2022: 55 · 2021: 53 · 2020: 58 · 2019: 48 · 2018: 51 · 2017: 67 · 2016: 61 · 2015: 40 · 2014: 43 · 2013: 22 · 2012: 10
- FWCI
- 14.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000064, 4r37ai039031-21, 5k23ai095398-05)
- National Heart, Lung, and Blood Institute (R01HL056067, R01HL069929)
- National Cancer Institute (P01CA023766, P01CA142106, R01CA107096, P30CA008748)
- National Institute of Allergy and Infectious Diseases (R01AI034495, R37-AI039031, R01AI100288, R01AI080455, K23-AI095398, P01AI056299, R01AI042135)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- intestinal inflammation, gut microbiota, allogeneic bone marrow transplantation, graft-versus-host disease, Lactobacillus, Lactobacillales, Clostridiales, microbial diversity, microbiome manipulation, gut microbiota composition
- MeSH terms
- Ampicillin, Animals, Base Sequence, Enterocolitis, Feces, Graft vs Host Disease, Gram-Positive Bacteria, Humans, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S, Species Specificity, Transplantation, Homologous, Bone Marrow Transplantation, Dextran Sulfate, Sequence Analysis, DNA, Biodiversity, Mice, Metagenome
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