The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Gata2 is required for HSC generation and survival
Open accessAbstract
Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC) generation is of particular importance for current hematopoietic regenerative approaches and reprogramming strategies. Whereas GATA2 has long been implicated as a hematopoietic transcription factor and its dysregulated expression is associated with human immunodeficiency syndromes and vascular integrity, it is as yet unknown how GATA2 functions in the generation of HSCs. HSCs are generated from endothelial cells of the major embryonic vasculature (aorta, vitelline, and umbilical arteries) and are found in intra-aortic hematopoietic clusters. In this study, we find that GATA2 function is essential for the generation of HSCs during the stage of endothelial-to-hematopoietic cell transition. Specific deletion of Gata2 in Vec (Vascular Endothelial Cadherin)-expressing endothelial cells results in a deficiency of long-term repopulating HSCs and intra-aortic cluster cells. By specific deletion of Gata2 in Vav-expressing hematopoietic cells (after HSC generation), we further show that GATA2 is essential for HSC survival. This is in contrast to the known activity of the RUNX1 transcription factor, which functions only in the generation of HSCs, and highlights the unique requirement for GATA2 function in HSCs throughout all developmental stages.
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Cites
An early haematopoietic defect in mice lacking the transcription factor GATA-2
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Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
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Self-citationIn vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
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Self-citationOf lineage and legacy: the development of mammalian hematopoietic stem cells
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Self-citationFate tracing reveals the endothelial origin of hematopoietic stem cells
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Self-citationHematopoietic Stem Cells Localize to the Endothelial Cell Layer in the Midgestation Mouse Aorta
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Self-citation
Cited by
A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia
Gröschel, S., Sanders, M. A., Hoogenboezem, R., de Wit, E., Bouwman, B. A. M., Erpelinck, C., van der Velden, V. H. J., Havermans, M., Avellino, R., van Lom, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.019 · Cited by 687
Using the Zebrafish as a Genetic Model to Study Erythropoiesis
Zhang, Y., Chen, M., & Chen, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910475 · Cited by 25
Metadata
- Authors
- de Pater, E., Kaimakis, P., Vink, C. S., Yokomizo, T., Yamada-Inagawa, T., van der Linden, R., Kartalaei, P. S., Camper, S. A., Speck, N., & Dzierzak, E.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2013-12-02
- Volume
- 210
- Issue
- 13
- Pages
- 2843-2850
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2136182167
- Cited by
- 257
- References
- 31
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- green
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- de Pater, E., Kaimakis, P., Vink, C. S., Yokomizo, T., Yamada-Inagawa, T., van der Linden, R., Kartalaei, P. S., Camper, S. A., Speck, N., & Dzierzak, E. (2013). Gata2 is required for HSC generation and survival. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20130751
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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