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Cited by 25Zebrafish Biomedical Research ApplicationsErythropoietin and Anemia TreatmentHematopoietic Stem Cell Transplantation

Using the Zebrafish as a Genetic Model to Study Erythropoiesis

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Zhang, Yuhan, Chen, Mengying, Chen, Caiyong·2021·International Journal of Molecular Sciences
DOI 10.3390/ijms221910475PMC PMC8508994
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Abstract

Vertebrates generate mature red blood cells (RBCs) via a highly regulated, multistep process called erythropoiesis. Erythropoiesis involves synthesis of heme and hemoglobin, clearance of the nuclei and other organelles, and remodeling of the plasma membrane, and these processes are exquisitely coordinated by specific regulatory factors including transcriptional factors and signaling molecules. Defects in erythropoiesis can lead to blood disorders such as congenital dyserythropoietic anemias, Diamond–Blackfan anemias, sideroblastic anemias, myelodysplastic syndrome, and porphyria. The molecular mechanisms of erythropoiesis are highly conserved between fish and mammals, and the zebrafish (Danio rerio) has provided a powerful genetic model for studying erythropoiesis. Studies in zebrafish have yielded important insights into RBC development and established a number of models for human blood diseases. Here, we focus on latest discoveries of the molecular processes and mechanisms regulating zebrafish erythropoiesis and summarize newly established zebrafish models of human anemias.

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  • Clusters RBC1-4 and 8 exhibited high expression of myb and id1, indicating HSC-like characteristics.

    “Clusters RBC1–4 and 8 exhibited high expression of myb and id1, indicating HSC-like characteristics (Perry et al., 2007; Singh et al., 2018; Zhang et al., 2021).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Zhang et al., 2021

    Section 2.2, “Definitive Erythropoiesis in Zebrafish” (page unavailable), identifies cmyb as a marker expressed by zebrafish HSCs, supporting the HSC-like interpretation of myb expression. The source does not report id1 expression or findings for clusters RBC1–4 and 8, so it does not support the specific cluster-level claim. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • The pseudotime starting point was determined based on expression of myb, a known marker for HSCs in zebrafish erythropoiesis.

    “The pseudotime starting point was determined based on the expression levels of the myb gene, a known marker for hematopoietic stem cells (HSCs) in zebrafish erythropoiesis (Zhang et al., 2021).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Zhang et al., 2021

  • The transient wave serves as an intermediate stage, producing some blood cells and leading to the emergence of temporary blood components.

    “The transient wave serves as an intermediate stage, producing some blood cells and leading to the emergence of temporary blood components (Zhang et al., 2021).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Zhang et al., 2021

  • Clusters RBC5 and 6 resemble common myeloid progenitors (CMPs) based on gata1a expression.

    “Clusters RBC5 and 6 were identified as resembling common myeloid progenitors (CMPs) based on the expression of gata1a (Zhang et al., 2021).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Zhang et al., 2021

    Section 2.1 discusses gata1 as a transcription factor in zebrafish erythropoiesis, but it does not identify RBC5 or RBC6 clusters or classify them as common myeloid progenitors. Searches for the cluster names, CMPs, and gata1a found no passage in our copy addressing that classification; page numbers were not available. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Zhang, Y., Chen, M., & Chen, C.
Affiliations
Zhejiang University (CN)
Corresponding author
Chen, Caiyong
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-09-28
Volume
22
Issue
19
Pages
10475
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms221910475
PMC
PMC8508994
OpenAlex
W3204188153
Cited by
25
References
10
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 8
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (31871200, 32071155)
  • National Key Research and Development Program of China (2018YFA0507802)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
erythropoiesis, zebrafish, red blood cell development, heme biosynthesis, hemoglobin, plasma membrane remodeling, transcription factors, signaling molecules, congenital dyserythropoietic anemia, Diamond-Blackfan anemia, sideroblastic anemia, myelodysplastic syndrome, porphyria, zebrafish disease models, hematologic disorders
MeSH terms
Anemia, Aplastic, Animals, Disease Models, Animal, Erythrocytes, Erythropoiesis, Humans, Zebrafish, Embryonic Development

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