The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance
Open accessAbstract
Dendritic cells (DCs), and more recently lymph node stromal cells (LNSCs), have been described to tolerize self-reactive CD8+ T cells in LNs. Although LNSCs express MHCII, it is unknown whether they can also impact CD4+ T cell functions. We show that the promoter IV (pIV) of class II transactivator (CIITA), the master regulator of MHCII expression, controls endogenous MHCII expression by LNSCs. Unexpectedly, LNSCs also acquire peptide–MHCII complexes from DCs and induce CD4+ T cell dysfunction by presenting transferred complexes to naive CD4+ T cells and preventing their proliferation and survival. Our data reveals a novel, alternative mechanism where LN-resident stromal cells tolerize CD4+ T cells through the presentation of self-antigens via transferred peptide–MHCII complexes of DC origin.
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Cites
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Swartz, M. A., & Lund, A. W. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3186 · Cited by 544
Self-citationAn inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, L. A., Clasper, S., Holt, A. P., Lalor, P. F., Baban, D., & Jackson, D. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051759 · Cited by 346
Cited by
Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241
Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells
Lindenbergh, M. F. S., & Stoorvogel, W. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055700 · Cited by 373
Lymph node fibroblastic reticular cells in health and disease
Fletcher, A. L., Acton, S. E., & Knoblich, K. (2015) · Nature Reviews Immunology · doi:10.1038/nri3846 · Cited by 340
The lymphatic system: integral roles in immunity
Randolph, G. J., Ivanov, S., Zinselmeyer, B. H., & Scallan, J. P. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055354 · Cited by 338
Microenvironmental Determinants of Pancreatic Cancer
Hessmann, E., Buchholz, S. M., Demir, I. E., Singh, S. K., Gress, T. M., Ellenrieder, V., & Neesse, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2019 · Cited by 331
Metadata
- Authors
- Dubrot, J., Duraes, F. V., Potin, L., Capotosti, F., Brighouse, D., Suter, T., LeibundGut-Landmann, S., Garbi, N., Reith, W., Swartz, M. A., & Hugues, S.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2014-05-19
- Volume
- 211
- Issue
- 6
- Pages
- 1153-1166
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2103144700
- Cited by
- 227
- References
- 2
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dubrot, J., Duraes, F. V., Potin, L., Capotosti, F., Brighouse, D., Suter, T., LeibundGut-Landmann, S., Garbi, N., Reith, W., Swartz, M. A., & Hugues, S. (2014). Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20132000
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