The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens
Open accessAbstract
The bZIP transcription factor Nfil3 (also known as E4BP4) is required for the development of natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s). We find that Nfil3 plays a critical role in the development of other mucosal tissue-associated innate lymphocytes. Type 3 ILCs (ILC3s), including lymphoid tissue inducer (LTi)–like cells, are severely diminished in both numbers and function in Nfil3-deficient mice. Using mixed bone marrow chimeric mice, we demonstrate that Nfil3 is critical for normal development of gut-associated ILC3s in a cell-intrinsic manner. Furthermore, Nfil3 deficiency severely compromises intestinal innate immune defense against acute bacterial infection with Citrobacter rodentium and Clostridium difficile. Nfil3 deficiency resulted in a loss of the recently identified ILC precursor, yet conditional ablation of Nfil3 in the NKp46+ ILC3 subset did not perturb ILC3 numbers, suggesting that Nfil3 is required early during ILC3 development but not for lineage maintenance. Lastly, a marked defect in type 2 ILCs (ILC2s) was also observed in the lungs and visceral adipose tissue of Nfil3-deficient mice, revealing a general requirement for Nfil3 in the development of all ILC lineages.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Clostridium difficile infection: new developments in epidemiology and pathogenesis
Rupnik, M., Wilcox, M. H., & Gerding, D. N. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2164 · Cited by 1,380 · cited 1×
“…is an opportunistic gram-positive bacterium that can cause severe colitis and diarrhea when the normal microbiota is disrupted after antibiotic treatment (Rupnik et al., 2009), and the incidence of infection in hospital settings is increasing, especially among BMT patients (Kelly and LaMont, 2008).”
BackgroundLee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2187 · Cited by 777
Buffie, C. G., Jarchum, I., Equinda, M., Lipuma, L., Gobourne, A., Viale, A., Ubeda, C., Xavier, J., & Pamer, E. G. (2012) · Infection and Immunity · doi:10.1128/iai.05496-11 · Cited by 596 · cited 2×
“3 F) previously shown to disrupt the intestinal microbiota and induce susceptibility to C. difficile spores and colitis (Buffie et al., 2012).”
BackgroundSelf-citation
Cited by
Dey, N., Wagner, V. E., Blanton, L. V., Cheng, J., Fontana, L., Haque, R., Ahmed, T., & Gordon, J. I. (2015) · Cell · doi:10.1016/j.cell.2015.08.059 · Cited by 195
Innate Lymphoid Cell Development: A T Cell Perspective
Cherrier, D. E., Serafini, N., & Di Santo, J. P. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.010 · Cited by 181
Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis
Zhou, J., Peng, H., Li, K., Qu, K., Wang, B., Wu, Y., Ye, L., Dong, Z., Wei, H., Sun, R., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.024 · Cited by 157
Development and differentiation of early innate lymphoid progenitors
Harly, C., Cam, M., Kaye, J., & Bhandoola, A. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20170832 · Cited by 125
Rothenberg, E. V., Ungerbäck, J., & Champhekar, A. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2015.09.002 · Cited by 61
Metadata
- Authors
- Geiger, T. L., Abt, M. C., Gasteiger, G., Firth, M. A., O’Connor, M. H., Geary, C. D., O’Sullivan, T. E., van den Brink, M. R., Pamer, E. G., Hanash, A. M., & Sun, J. C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2014-08-11
- Volume
- 211
- Issue
- 9
- Pages
- 1723-1731
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2097807376
- Cited by
- 269
- References
- 4
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. https://app.cochat.ai/papers/10.1084/jem.20140212
- The paper
- Geiger, T. L., Abt, M. C., Gasteiger, G., Firth, M. A., O’Connor, M. H., Geary, C. D., O’Sullivan, T. E., van den Brink, M. R., Pamer, E. G., Hanash, A. M., & Sun, J. C. (2014). Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20140212
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
