The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens
Open accessAbstract
The bZIP transcription factor Nfil3 (also known as E4BP4) is required for the development of natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s). We find that Nfil3 plays a critical role in the development of other mucosal tissue-associated innate lymphocytes. Type 3 ILCs (ILC3s), including lymphoid tissue inducer (LTi)–like cells, are severely diminished in both numbers and function in Nfil3-deficient mice. Using mixed bone marrow chimeric mice, we demonstrate that Nfil3 is critical for normal development of gut-associated ILC3s in a cell-intrinsic manner. Furthermore, Nfil3 deficiency severely compromises intestinal innate immune defense against acute bacterial infection with Citrobacter rodentium and Clostridium difficile. Nfil3 deficiency resulted in a loss of the recently identified ILC precursor, yet conditional ablation of Nfil3 in the NKp46+ ILC3 subset did not perturb ILC3 numbers, suggesting that Nfil3 is required early during ILC3 development but not for lineage maintenance. Lastly, a marked defect in type 2 ILCs (ILC2s) was also observed in the lungs and visceral adipose tissue of Nfil3-deficient mice, revealing a general requirement for Nfil3 in the development of all ILC lineages.
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Citations
Cites
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
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BackgroundLee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2187 · Cited by 777
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“3 F) previously shown to disrupt the intestinal microbiota and induce susceptibility to C. difficile spores and colitis (Buffie et al., 2012).”
BackgroundSelf-citation
Cited by
Dey, N., Wagner, V. E., Blanton, L. V., Cheng, J., Fontana, L., Haque, R., Ahmed, T., & Gordon, J. I. (2015) · Cell · doi:10.1016/j.cell.2015.08.059 · Cited by 195
Innate Lymphoid Cell Development: A T Cell Perspective
Cherrier, D. E., Serafini, N., & Di Santo, J. P. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.010 · Cited by 181
Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis
Zhou, J., Peng, H., Li, K., Qu, K., Wang, B., Wu, Y., Ye, L., Dong, Z., Wei, H., Sun, R., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.024 · Cited by 157
Development and differentiation of early innate lymphoid progenitors
Harly, C., Cam, M., Kaye, J., & Bhandoola, A. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20170832 · Cited by 125
Rothenberg, E. V., Ungerbäck, J., & Champhekar, A. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2015.09.002 · Cited by 61
The origin and role of innate lymphoid cells in the lung
Lai, D.-M., Shu, Q., & Fan, J. (2016) · Military Medical Research · doi:10.1186/s40779-016-0093-2 · Cited by 45
Zhuo, H., & Liu, J. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.11.028 · Cited by 19
Colonization and effector functions of innate lymphoid cells in mucosal tissues
Kim, M., & Kim, C. H. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.06.005 · Cited by 16
Metadata
- Authors
- Geiger, T. L., Abt, M. C., Gasteiger, G., Firth, M. A., O’Connor, M. H., Geary, C. D., O’Sullivan, T. E., van den Brink, M. R., Pamer, E. G., Hanash, A. M., & Sun, J. C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2014-08-11
- Volume
- 211
- Issue
- 9
- Pages
- 1723-1731
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2097807376
- Cited by
- 269
- References
- 4
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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