The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
Open accessAbstract
The transcription factor Gata6 regulates proliferation and differentiation of epithelial and endocrine cells and cancers. Among hematopoietic cells, Gata6 is expressed selectively in resident peritoneal macrophages. We thus examined whether the loss of Gata6 in the macrophage compartment affected peritoneal macrophages, using Lyz2-Cre x Gata6flox/flox mice to tackle this issue. In Lyz2-Cre x Gata6flox/flox mice, the resident peritoneal macrophage compartment, but not macrophages in other organs, was contracted, with only a third the normal number of macrophages remaining. Heightened rates of death explained the marked decrease in peritoneal macrophage observed. The metabolism of the remaining macrophages was skewed to favor oxidative phosphorylation and alternative activation markers were spontaneously and selectively induced in Gata6-deficient macrophages. Gene expression profiling revealed perturbed metabolic regulators, including aspartoacylase (Aspa), which facilitates generation of acetyl CoA. Mutant mice lacking functional Aspa phenocopied the higher propensity to death and led to a contraction of resident peritoneal macrophages. Thus, Gata6 regulates differentiation, metabolism, and survival of resident peritoneal macrophages.
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Cites
Alternative activation of macrophages: mechanism and functions
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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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Macrophages: Development and Tissue Specialization
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Metadata
- Authors
- Gautier, E. L., Ivanov, S., Williams, J. W., Huang, S. C.-C., Marcelin, G., Fairfax, K., Wang, P. L., Francis, J. S., Leone, P., Wilson, D. B., Artyomov, M. N., Pearce, E. J., & Randolph, G. J.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2014-07-14
- Volume
- 211
- Issue
- 8
- Pages
- 1525-1531
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2170625377
- Cited by
- 207
- References
- 12
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gautier, E. L., Ivanov, S., Williams, J. W., Huang, S. C.-C., Marcelin, G., Fairfax, K., Wang, P. L., Francis, J. S., Leone, P., Wilson, D. B., Artyomov, M. N., Pearce, E. J., & Randolph, G. J. (2014). Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20140570
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