The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Open accessAbstract
Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ∼28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
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Citations
Cites
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion
Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.-C., Lu, D., Campos, L., Goulding, D., Ng, B. L., et al. (2010) · Science · doi:10.1126/science.1188063 · Cited by 374
Self-citation
Cited by
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway
Yu, Y., Tsang, J. C. H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L. S., Lu, L., et al. (2016) · Nature · doi:10.1038/nature20105 · Cited by 306
Self-citationInnate Lymphoid Cell Development: A T Cell Perspective
Cherrier, D. E., Serafini, N., & Di Santo, J. P. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.010 · Cited by 181
Fang, D., & Zhu, J. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170494 · Cited by 175
Development and differentiation of early innate lymphoid progenitors
Harly, C., Cam, M., Kaye, J., & Bhandoola, A. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20170832 · Cited by 125
Metadata
- Authors
- Yu, Y., Wang, C., Clare, S., Wang, J., Lee, S.-C., Brandt, C., Burke, S., Lu, L., He, D., Jenkins, N. A., Copeland, N. G., Dougan, G., & Liu, P.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2015-05-11
- Volume
- 212
- Issue
- 6
- Pages
- 865-874
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1898649886
- Cited by
- 162
- References
- 2
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yu, Y., Wang, C., Clare, S., Wang, J., Lee, S.-C., Brandt, C., Burke, S., Lu, L., He, D., Jenkins, N. A., Copeland, N. G., Dougan, G., & Liu, P. (2015). The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20142318
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