Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion
Open accessAbstract
One Two T: T cells develop in the thymus, where they proceed through several developmental stages, losing alternative lineage potential as they progress. The molecular regulation of this developmental process, however, is not fully understood (see the Perspective by Di Santo ). P. Li et al. (p. 85 , published online 10 June), L. Li et al. (p. 89 ), and Ikawa et al. (p. 93 ) now identify expression of the zinc finger transcription factor Bcl11b as the earliest checkpoint in T cell development in mice. Genetic deletion of Bcl11b in developing T cells inhibited commitment to the T cell lineage. Under conditions that should have stimulated T lineage differentiation, Bcl11b -deficient T cell progenitors failed to up-regulate genes associated with lineage-committed T cells and maintained stem cell– and progenitor cell–associated gene expression. In both developing and committed T cells, loss of Bcl11b resulted in the generation of cells that resembled natural killer (NK) cells in both phenotype and function. These NK-like cells could be expanded easily in vitro and possessed antitumor cytotoxicity, but they did not exhibit cytotoxicity against normal cells and were not tumorigenic. Because T cells are much easier to obtain from human patients than NK cells, deletion of Bcl11b in T cells may thus provide a source of easy-to-grow NK cells for cell-based antitumor therapies.
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Loss of master regulators, such as Pax5 in B cells, can cause plasticity and even cancer.
“Their loss, for example, Pax5 in B cells, can cause plasticity and even cancer6,7,55,56.”
From Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis (2025) · cites this paper as [55]
The paper reports that deleting the transcription factor Bcl11b caused T cells to acquire NK-cell properties, supporting the general point that loss of a lineage regulator can cause plasticity. It does not report Pax5 loss in B cells or cancer caused by regulator loss. Its tumor finding is instead that the reprogrammed cells killed tumor cells and prevented metastasis (Abstract; no page given in our copy). (LLM, conf=0.86)
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- Authors
- Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.-C., Lu, D., Campos, L., Goulding, D., Ng, B. L., Dougan, G., Huntly, B., Gottgens, B., Jenkins, N. A., Copeland, N. G., Colucci, F., & Liu, P.
- Affiliations
- Wellcome Sanger Institute (GB)
- Babraham Institute (GB)
- National Cancer Institute (US)
- Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.
- Wellcome Trust (GB)
- Cambridge Institute for Medical Research, Wellcome Trust–MRC Building, Hills Road, Cambridge CB2 0XY, UK.
- Institute of Molecular and Cell Biology (SG)
- Corresponding author
- Liu, Pentao
- ORCID
- Venue
- Science
- Published
- 2010-07-02
- Volume
- 329
- Issue
- 5987
- Pages
- 85-89
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3628452
- OpenAlex
- W2010957709
- Cited by
- 374
- References
- 26
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 28 · 2023: 11 · 2022: 17 · 2021: 28 · 2020: 16 · 2019: 26 · 2018: 24 · 2017: 14 · 2016: 27 · 2015: 20 · 2014: 21 · 2013: 24 · 2012: 26
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Wellcome Trust (077186, 076962)
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (G0900729/1)
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- BCL11B, T cell development, NK-like cells, lineage commitment, thymus development, zinc finger transcription factor, T cell progenitors, tumor cytotoxicity, NK cell expansion
- MeSH terms
- Animals, Cells, Cultured, Cytotoxicity, Immunologic, Killer Cells, Natural, Melanoma, Experimental, Mice, Inbred C57BL, Repressor Proteins, T-Lymphocytes, Tamoxifen, Signal Transduction, Receptors, Antigen, T-Cell, alpha-beta, Stromal Cells, Gene Deletion, Mice, Knockout, Gene Expression Regulation, Developmental, Coculture Techniques, Cell Lineage, Genes, T-Cell Receptor beta, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Tumor Suppressor Proteins, Lymphopoiesis, Cell Line, Tumor, Mice, Precursor Cells, T-Lymphoid, Gene Knock-In Techniques
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