The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The interaction of anticancer therapies with tumor-associated macrophages
Open accessAbstract
Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor-associated macrophages (TAMs). Chemotherapy and radiotherapy can have dual influences on TAMs in that a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in other circumstances, TAMs are essential for effective therapy. A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy.
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Cites
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BackgroundTumor-Associated Macrophages: From Mechanisms to Therapy
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Cited by
Yunna, C., Mengru, H., Lei, W., & Weidong, C. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173090 · Cited by 2,454
Macrophages and metabolism in the tumor microenvironment
Vitale, I., Manic, G., Coussens, L. M., Kroemer, G., & Galluzzi, L. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.001 · Cited by 1,837
Tumor microenvironment and therapeutic response
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Metadata
- Authors
- Mantovani, A., & Allavena, P.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2015-03-09
- Volume
- 212
- Issue
- 4
- Pages
- 435-445
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2113082145
- Cited by
- 616
- References
- 25
- FWCI
- 29.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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