Cited by 181Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisPancreatic and Hepatic Oncology Research

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Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

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Recouvreux, Maria Victoria, Moldenhauer, Matthew R., Galenkamp, Koen M.O., Jung, Michael, James, Brian, Zhang, Yijuan, Lowy, Andrew, Bagchi, Anindya, Commisso, Cosimo·2020·Journal of Experimental Medicine

DOI 10.1084/jem.20200388PMC PMC7478719

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Abstract

Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing metabolic stress that has the potential to impact tumor progression. Here, we show that nutrient stress caused by glutamine deprivation leads to the induction of epithelial–mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, we demonstrate that glutamine deficiency regulates EMT through the up-regulation of the EMT master regulator Slug, a process that is dependent on both MEK/ERK signaling and ATF4. We find that Slug is required in PDAC cells for glutamine deprivation–induced EMT, cell motility, and nutrient stress survival. Importantly, we decipher that Slug is associated with nutrient stress in PDAC tumors and is required for metastasis. These results delineate a novel role for Slug in the nutrient stress response and provide insight into how nutrient depletion might influence PDAC progression.

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Authors: Recouvreux, M. V., Moldenhauer, M. R., Galenkamp, K. M. O., Jung, M., James, B., Zhang, Y., Lowy, A., Bagchi, A., & Commisso, C.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
University of California San Diego (US)
Corresponding author: Commisso, Cosimo
ORCID: Moldenhauer, Matthew R.
Galenkamp, Koen M.O.
James, Brian
Zhang, Yijuan
Lowy, Andrew
Bagchi, Anindya
Commisso, Cosimo
Venue: Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2020-06-08
Volume: 217
Issue: 9
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20200388
PMC: PMC7478719
OpenAlex: W3032930460
Cited by: 181
References: 57
Citations by year: 2026: 15 · 2025: 33 · 2024: 28 · 2023: 37 · 2022: 40 · 2021: 23 · 2020: 4
FWCI: 8.87
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.rupress.org/terms/ (vor)
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 272 d)
Locations: The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health (R01CA207189)
National Cancer Institute (P30CA030199)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Keywords: glutamine deprivation, Slug, epithelial-mesenchymal transition, pancreatic ductal adenocarcinoma, nutritional stress, metabolic stress, MEK/ERK signaling, ATF4, metastasis, cell motility, tumor progression
MeSH terms: Snail Family Transcription Factors, Adenocarcinoma, Animals, Cell Movement, Cell Survival, Glutamine, Humans, Mice, Inbred C57BL, Neoplasm Metastasis, Pancreatic Neoplasms, RNA, Messenger, Stress, Physiological, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, MAP Kinase Signaling System, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Activating Transcription Factor 4, HEK293 Cells, Epithelial-Mesenchymal Transition

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Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

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