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Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
Open accessAbstract
Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor cells to dynamically replenish myeloid lineage cells in a process known as emergency myelopoiesis. However, it is increasingly appreciated that the same proinflammatory signaling pathways are used in diverse hematopoietic scenarios. This review focuses on inflammatory signaling in the emergence of the definitive hematopoietic compartment during embryonic life, and tonic inflammatory signals derived from commensal microbiota in shaping the adult hematopoietic compartment in the absence of pathogenic insults. Insights into the unique and shared aspects of inflammatory signaling that regulate hematopoietic stem and progenitor cell function across the lifespan and health span of an individual will enable better diagnostic and therapeutic approaches to hematopoietic dysregulation and malignancies.
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““Emergency” myelopoiesis is a critical response to physiological insults that supplies the host with enough innate immune cells to fight infections and/or contribute to the repair and immunosurveillance of damaged tissues (Caiado et al., 2021; Collins et al., 2021).”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Collins et al., 2021
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Reversible loss of hematopoietic stem cells transplant potency by chronic Salmonella infection
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Inflammatory Network Architecture Across Bone Marrow Failure: An Immune-Genetic Continuum
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Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo
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Metadata
- Authors
- Collins, A., Mitchell, C. A., & Passegué, E.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 1
- Corresponding author
- Collins, Amélie
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-06-15
- Volume
- 218
- Issue
- 7
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC8210624
- OpenAlex
- W3168900950
- Cited by
- 111
- References
- 118
- Citations by year
- 2026: 24 · 2025: 24 · 2024: 32 · 2023: 22 · 2022: 8 · 2021: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K08-DK124657)
- Louis V. Gerstner Jr. Scholar Award
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R35-HL135763)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- inflammatory signaling, hematopoietic stem and progenitor cells, emergency myelopoiesis, inflammatory cytokines, definitive hematopoiesis, embryonic hematopoiesis, commensal microbiota, hematopoietic homeostasis, myeloid lineage, hematologic malignancies
- MeSH terms
- Animals, Hematopoiesis, Hematopoietic Stem Cells, Homeostasis, Humans, Inflammation, Stem Cells, Signal Transduction, Myeloid Cells, Myelopoiesis
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