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THE DESOXYRIBONUCLEIC ACID CONTENT OF ANIMAL CELLS AND ITS EVOLUTIONARY SIGNIFICANCE
Open accessAbstract
1. Evidence is summarized for the constancy of DNA content for each set of chromosomes in the various cells of an organism. 2. The DNA contents of the egg and sperm nuclei are the same. 3. A brief survey is given of DNA contents per cell in invertebrates and vertebrates. (a) In invertebrates there is some slight evidence that when primitive and higher forms are compared the amount of DNA per cell is increased in the latter. (b) In fishes there is a tendency for the amount of DNA per cell to remain constant within the different species of a family. (c) The values of DNA per cell in lung fishes, amphibians, reptiles, and birds suggest that in the evolution of these vertebrates there has been a decline in DNA content per cell. 4. Concerning the significance of quantity of DNA per cell in vertebrates: (a) It appears not to be in proportion to the number of different genes in a cell. (b) It may be related to the number of strands in the chromosomes. (c) In homologous cells of different animals it is directly related to the mass of the cell.
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Citations
Cited by
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Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
Coincidence, coevolution, or causation? DNA content, cellsize, and the C‐value enigma
GREGORY, T. R. (2001) · Biological Reviews · doi:10.1111/j.1469-185x.2000.tb00059.x · Cited by 730
Synergy between sequence and size in Large-scale genomics
Gregory, T. R. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1674 · Cited by 348
The nucleotypic effects of cellular DNA content in cartilaginous and ray-finned fishes
Hardie, D. C., & Hebert, P. D. N. (2003) · Genome · doi:10.1139/g03-040 · Cited by 149
Macroevolutionary shift in the size of amphibian genomes and the role of life history and climate
Liedtke, H. C., Gower, D. J., Wilkinson, M., & Gomez-Mestre, I. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0674-4 · Cited by 130
Metadata
- Authors
- Mirsky, A. E., & Ris, H.
- Venue
- Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1951-03-20
- Volume
- 34
- Issue
- 4
- Pages
- 451-462
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W1972815947
- Cited by
- 489
- References
- 0
- FWCI
- 28.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE DESOXYRIBONUCLEIC ACID CONTENT OF ANIMAL CELLS AND ITS EVOLUTIONARY SIGNIFICANCE. https://app.cochat.ai/papers/10.1085/jgp.34.4.451
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- Mirsky, A. E., & Ris, H. (1951). THE DESOXYRIBONUCLEIC ACID CONTENT OF ANIMAL CELLS AND ITS EVOLUTIONARY SIGNIFICANCE. Journal of General Physiology. https://doi.org/10.1085/jgp.34.4.451
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
