The genomics of selection in dogs and the parallel evolution between dogs and humans
Open accessAbstract
The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.
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These results are in line with claims in other studies on domestication, where categories like 'neurological process' frequently stand out strongly in gene ontology category enrichment analyses.
“These results are in line with claims in other studies on domestication [49, 123–125], where categories like ‘neurological process’ frequently stand out strongly in gene ontology category enrichment analyses.”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [124]
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Amy2Bcopy number variation reveals starch diet adaptations in ancient European dogs
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Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids
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Population genomic analysis reveals that homoploid hybrid speciation can be a lengthy process
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A genome-wide scan for signatures of directional selection in domesticated pigs
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On the origin of mongrels: evolutionary history of free-breeding dogs in Eurasia
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Identification of genomic variants putatively targeted by selection during dog domestication
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On the path to extinction: Inbreeding and admixture in a declining grey wolf population
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Taxonomic status of the Australian dingo: the case for Canis dingo Meyer, 1793
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Genomes of Pleistocene Siberian Wolves Uncover Multiple Extinct Wolf Lineages
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Elucidating biogeographical patterns in Australian native canids using genome wide SNPs
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De Novo Mutation Rate Estimation in Wolves of Known Pedigree
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How Much Is That in Dog Years? The Advent of Canine Population Genomics
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In search of Paleolithic dogs: a quest with mixed results
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Paleogenomic Inferences of Dog Domestication
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New insights on the history of canids in Oceania based on mitochondrial and nuclear data
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Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine
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Dog Breed Differences in Visual Communication with Humans
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Psychobiological Factors Affecting Cortisol Variability in Human-Dog Dyads
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The canine gastrointestinal microbiota: early studies and research frontiers
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Glutamate receptors in domestication and modern human evolution
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Evolutionary History, Selective Sweeps, and Deleterious Variation in the Dog
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Neural processes of vocal social perception: Dog-human comparative fMRI studies
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An Evolutionary Genomic Perspective on the Breeding of Dwarf Chickens
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Three-Dimensional Geometric Morphometric Analysis of Fossil Canid Mandibles and Skulls
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Human Evolution beyond Biology and Culture
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- Authors
- Wang, G.-D., Zhai, W., Yang, H.-C., Fan, R.-X., Cao, X., Zhong, L., Wang, L., Liu, F., Wu, H., Cheng, L.-G., Poyarkov, A. D., Poyarkov JR, N. A., Tang, S.-S., Zhao, W.-M., Gao, Y., Lv, X.-M., Irwin, D. M., Savolainen, P., Wu, C.-I., & Zhang, Y.-P.
- Affiliations
- Chinese Academy of Sciences (CN)
- Kunming Institute of Zoology (CN)
- Yunnan University (CN)
- Ministry of Public Security of the People's Republic of China (CN)
- Russian Academy of Sciences (RU)
- Science for Life Laboratory (SE)
- University of Science and Technology of China (CN)
- Corresponding author
- Wu, Chung-I
- Zhang, Ya-ping
- ORCID
- Venue
- Nature Communications
- Published
- 2013-05-14
- Volume
- 4
- Issue
- 1
- Pages
- 1860-1860
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2138655328
- Cited by
- 323
- References
- 60
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 14 · 2023: 20 · 2022: 23 · 2021: 18 · 2020: 38 · 2019: 32 · 2018: 47 · 2017: 28 · 2016: 33 · 2015: 20 · 2014: 21 · 2013: 5
- FWCI
- 17.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Royal Swedish Academy of Sciences
- National Natural Science Foundation of China (91231108)
- Chinese Academy of Sciences (2013CB835200)
- Knut och Alice Wallenbergs Stiftelse
- National Key Research and Development Program of China (2013CB835200)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- dog domestication, positive selection, parallel evolution, gray wolves, dog breeds, population bottleneck, scavenging, cancer genes
- MeSH terms
- Animals, Animals, Domestic, China, Dogs, Genetics, Population, Geography, Humans, Population Dynamics, Selection, Genetic, Genetic Variation, Sequence Analysis, DNA, Evolution, Molecular, Wolves, Genomics, Principal Component Analysis, Genetic Association Studies, High-Throughput Nucleotide Sequencing, Gene Ontology
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