The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity
Abstract
T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P<.05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.
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Cites
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Cited by
Libraty, D. H., Endy, T. P., Houng, H. H., Green, S., Kalayanarooj, S., Suntayakorn, S., Chansiriwongs, W., Vaughn, D. W., Nisalak, A., Ennis, F. A., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/340365 · Cited by 494
Self-citationInfection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production
Ho, L.-J., Wang, J.-J., Shaio, M.-F., Kao, C.-L., Chang, D.-M., Han, S.-W., & Lai, J.-H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1499 · Cited by 314
Azeredo, E. L. D., Monteiro, R. Q., & de-Oliveira Pinto, L. M. (2015) · Mediators of Inflammation · doi:10.1155/2015/313842 · Cited by 288
Immune-mediated cytokine storm and its role in severe dengue
Srikiatkhachorn, A., Mathew, A., & Rothman, A. L. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0625-1 · Cited by 267
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Metadata
- Authors
- Green, S., Vaughn, D. W., Kalayanarooj, S., Nimmannitya, S., Suntayakorn, S., Nisalak, A., Lew, R., Innis, B. L., Kurane, I., Rothman, A. L., & Ennis, F. A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-04
- Volume
- 179
- Issue
- 4
- Pages
- 755-762
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2115005895
- Cited by
- 371
- References
- 32
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Green, S., Vaughn, D. W., Kalayanarooj, S., Nimmannitya, S., Suntayakorn, S., Nisalak, A., Lew, R., Innis, B. L., Kurane, I., Rothman, A. L., & Ennis, F. A. (1999). Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity. The Journal of Infectious Diseases. https://doi.org/10.1086/314680
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