Effect of transfusional iron overload on immune response.
Abstract
Increased susceptibility to infectious disease is observed in persons with transfusion-dependent thalassemia and iron overload who experience increased exposure to pathogens and chronic immune stimulation. An abnormal low CD8(+) T (LT8) immune phenotype defines a subgroup of patients. The CD8(+) T cell immunophenotype is stable despite continued blood transfusion and is independent of age. CD8(+) T cells, but not CD4(+) T cells, were modulated during intravenous chelation with deferoxamine. Return to characteristic pretreatment levels of CD8 was observed in both the low and the normal groups, suggesting the possibility of a set point. Proliferative response to mitogens and antigens was increased by chelation. Because CD8(+) T cells are important in immune response to infectious disease, these studies suggest that intrinsic CD8(+) T cell subset differences may be a critical factor in determining susceptibility to infection independent of transfusional iron overload or alloantigen exposure.
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These observations are consistent with reports of greater microbial burden in patients with Fe overload disease and predict that mutations affecting macrophage Fe levels may compromise microbial containment and dictate dependence of microbes on distinct mechanisms of Fe uptake.
“These observations are consistent with reports of greater microbial burden in patients with Fe overload disease [15], [18], [19], [20], [21] and predict that mutations affecting macrophage Fe levels may not only compromise microbial containment, but may also dictate the dependence of microbes on distinct mechanisms of Fe uptake.”
From Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing (2011) · cites this paper as [19]
Transfusion-dependent thalassemia patients present with increased susceptibility to widespread microbial infection that correlates with the degree of Fe overload.
“In the same way, transfusion-dependent thalassemia patients present with increased susceptibility to widespread microbial infection that correlates with the degree of Fe overload [19].”
From Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing (2011) · cites this paper as [19]
Cites
Szer, J. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127745.x · Cited by 3,376 · see citing works
Clinical diagnosis and management by laboratory methods
Henry, J. B. (1979) · Medical Entomology and Zoology · Cited by 1,699 · see citing works
Zinc and immune function: the biological basis of altered resistance to infection
Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606 · see citing works
Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebrón, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., & Schatzman, R. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1472 · Cited by 827 · see citing works
Lebrón, J., Bennett, M. J., Vaughn, D., Chirino, A., Snow, P., Mintier, G., Feder, J., & Bjorkman, P. (1998) · Cell · doi:10.1016/s0092-8674(00)81151-4 · Cited by 636 · see citing works
Iron metabolism in health and disease
Brock, J. H., Halliday, J. W., Pippard, M. J., & Powell, L. W. (1994) · Cited by 286 · see citing works
Pathophysiology of Iron Overloada
Hershko, C., Link, G., & Cabantchik, I. Z. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10475.x · Cited by 246 · see citing works
Heterogeneity of hemochromatosis in Italy
Piperno, A., Sampietro, M., Pietrangelo, A., Arosio, C., Lupica, L., Montosi, G., Vergani, A., Fraquelli, M., Girelli, D., & Pasquero, P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70319-1 · Cited by 235 · see citing works
Gross, C. N., Irrinki, A., Feder, J. N., & Enns, C. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.22068 · Cited by 227 · see citing works
Genes that modify the hemochromatosis phenotype in mice
Levy, J. E., Montross, L. K., & Andrews, N. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9635 · Cited by 212 · see citing works
Patruta, S. I., Edlinger, R., Sunder-Plassmann, G., & Hörl, W. H. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v94655 · Cited by 182 · see citing works
Dadone, M. M., Kushner, J. P., Edwards, C. Q., Bishop, D. T., & Skolnick, M. H. (1982) · American Journal of Clinical Pathology · doi:10.1093/ajcp/78.2.196 · Cited by 178 · see citing works
Iron Overload Alters Innate and T Helper Cell Responses to<i>Candida albicans</i>in Mice
Mencacci, A., Cenci, E., Boelaert, J. R., Bucci, P., Mosci, P., d'Ostiani, C. F., Bistoni, F., & Romani, L. (1997) · The Journal of Infectious Diseases · doi:10.1086/516481 · Cited by 169 · cited 1× · see citing works
“Iron may favor the growth of intracellular pathogens by reducing production of key cytokines and by inhibiting phagocytic function [9].”
BackgroundCHRONIC MUCO-CUTANEOUS CANDIDIASIS: ASSOCIATED ABNORMALITIES OF IRON METABOLISM
Higgs, J. M., & Wells, R. S. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb15420.x · Cited by 149 · see citing works
Walter, T., Olivares, M., Pizarro, F., & Muñoz, C. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1997.tb06462.x · Cited by 143 · see citing works
The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C
Kazemi-Shirazi, L., Datz, C., Maier-Dobersberger, T., Kaserer, K., Hackl, F., Polli, C., Steindl, P. E., Penner, E., & Ferenci, P. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70236-2 · Cited by 135 · see citing works
Nutrition in pediatrics: basic science and clinical applications.
Duggan, C., Watkins, J. B., & Walker, W. A. (2008) · B.C. Decker eBooks · Cited by 130 · see citing works
Hypoxia inhibits macrophage migration
Turner, L., Scotton, C. J., Negus, R. P. M., & Balkwill, F. R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199907)29:07 · Cited by 117 · see citing works
Clemente, M. G., Congia, M., Lai, M. E., Lilliu, F., Lampis, R., Frau, F., Frau, M. R., Faa, G., Diana, G., Dessì, C., et al. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(94)70138-5 · Cited by 115 · see citing works
LONGITUDINAL STUDY OF CARDIAC FUNCTION IN THALASSEMIA MAJOR *
Ehlers, K. H., Levin, A. R., Markenson, A. L., Marcus, J. R., Klein, A. A., Hilgartner, M. W., & Engle, M. A. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb33678.x · Cited by 114 · see citing works
SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis
Hill, P. J., Cockayne, A., Landers, P., Morrissey, J. A., Sims, C. M., & Williams, P. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.9.4123-4129.1998 · Cited by 110 · see citing works
Adamkiewicz, T. V., Berkovitch, M., Krishnan, C., Polsinelli, C., Kermack, D., & Olivieri, N. F. (1998) · Clinical Infectious Diseases · doi:10.1086/515025 · Cited by 103 · see citing works
Pathophysiology of Iron Toxicity
Britton, R. S., Ramm, G. A., Olynyk, J. K., Singh, R., O’Neill, R., & Bacon, B. R. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2554-7_26 · Cited by 102 · see citing works
Microbial iron transport: iron acquisition by pathogenic microorganisms.
Byers, B. R., & Arceneaux, J. E. L. (1998) · PubMed · Cited by 101 · see citing works
The effects of iron deficiency and iron overload on cell-mediated immunity in the mouse
Omara, F. O., & Blakley, B. R. (1994) · British Journal of Nutrition · doi:10.1079/bjn19940094 · Cited by 89 · see citing works
Chelation therapy in beta-thalassemia: the benefits and limitations of desferrioxamine.
Giardina, P. J., & Grady, R. W. (1995) · PubMed · Cited by 73 · see citing works
Self-citationTransfusion‐transmitted human parvovirus B19 infection in a thalassemic patient
Zanella, A., Rossi, F. G., Cesana, C., Foresti, A. L., Nador, F., Binda, A., Lunghi, G., Cappellini, M. D., Furione, M., & Sirchia, G. (1995) · Transfusion · doi:10.1046/j.1537-2995.1995.35996029163.x · Cited by 73 · see citing works
Grady, R. W., Akbar, A. N., Giardina, P. J., Hilgartner, M. W., & de Sousa, M. A. B. (1985) · British Journal of Haematology · doi:10.1111/j.1365-2141.1985.tb07367.x · Cited by 72 · see citing works
Self-citationRelative Impact of Hla Phenotype and Cd4–Cd8 Ratios on the Clinical Expression of Hemochromatosis
Porto, G., Vicente, C. M. F. D. B., Teixeira, M., Martins, O., Cabeda, J. M., Lacerda, R., Gonçalves, C., Fraga, J., Macedo, G., Silva, B. M., et al. (1997) · Hepatology · doi:10.1002/hep.510250223 · Cited by 72 · see citing works
Genotype-phenotype correlations in β-thalassemias
Cao, A., Galanello, R., & Rosatelli, M. C. (1994) · Blood Reviews · doi:10.1016/0268-960x(94)90002-7 · Cited by 71 · see citing works
Abnormalities in the immune system of children with beta-thalassaemia major.
Dwyer, J., Wood, C., McNamara, J., Williams, A., Andiman, W. A., Rink, L., O'Connor, T., & Pearson, H. (1987) · PubMed Central · Cited by 69 · see citing works
Porto, G., Reimαo, R., Gonçalves, C., Vicente, C. M. F. D. B., Justiça, B., & de Sousa, M. A. B. (1994) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1994.tb00097.x · Cited by 68 · see citing works
Serum Ferritin, Desferrioxamine, and Evolution of HIV-1 Infection in Thalassemic Patients
Salhi, Y., Costagliola, D. G., Rebulla, P., Dessì, C., Karagiorga, M., Lena‐Russo, D., de Montalembert, M., & Girot, R. (1998) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199808150-00009 · Cited by 66 · see citing works
Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes.
Parkkila, S., Parkkila, A. K., Waheed, A., Britton, R. S., Xy, Z., Fleming, R. E., Tomatsu, S., Br, B., & Sly, W. S. (2000) · PubMed · Cited by 66 · see citing works
The immunological system in hemochromatosis
de Sousa, M. A. B., & Porto, G. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80367-x · Cited by 59 · see citing works
Mechanisms of adjuvancy: I?metal oxides as adjuvants
Naim, J. O. (1997) · Vaccine · doi:10.1016/s0264-410x(97)00016-9 · Cited by 54 · see citing works
Lombardi, G., Matera, R., Minervini, M. C., Cascavilla, N., D’Arcangelo, P., Carotenuto, M., Giorgio, G. D., & Musto, P. (1994) · PubMed · Cited by 51 · see citing works
Dose of desferrioxamine and evolution of HIV‐1 infection in thalassaemic patients
Costagliola, D. G., de Montalembert, M., Lefrère, J., Briand, C., Rebulla, P., Baruchel, S., Dessì, C., Fondu, P., Karagiorga, M., Perrimond, H., et al. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb06750.x · Cited by 50 · see citing works
Iron and Lymphocytes: Reciprocal Regulatory Interactions1
de Sousa, M. A. B., Reim�o, R., Porto, G. A., Grady, R. W., Hilgartner, M. W., & Giardina, P. J. (2015) · Current studies in hematology and blood transfusion · doi:10.1159/000419357 · Cited by 44 · see citing works
Self-citationBOSCOLO, P., Gioacchino, M. D., Sabbioni, E., Benvenuti, F., Conti, P., Reale, M., Bavazzano, P., & Giuliano, G. (1999) · International Archives of Occupational and Environmental Health · doi:10.1007/s004200050330 · Cited by 42 · see citing works
Ikuta, K., Fujimoto, Y., Suzuki, Y., Tanaka, K., Saito, H., Ohhira, M., Sasaki, K., & Kohgo, Y. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00016-1 · Cited by 42 · see citing works
Borgna‐Pignatti, C., Solinas, A., Bombieri, C., Micciolo, R., Gamberini, M. R., Stefano, P. D., Menis, E. D., & Pignatti, P. F. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.01067.x · Cited by 40 · see citing works
Decreased Lymphocyte Subsets and K-Cell Activity in Iron Deficiency Anemia
Santos, P. C., & Falcão, R. P. (2009) · Acta Haematologica · doi:10.1159/000205047 · Cited by 36 · see citing works
Prospective study of Yersinia enterocolitica infection in thalassemic patients
Cherchi, G. B., Pacifico, L., Cossellu, S., Gallisai, D., Zanetti, S., Fadda, G. M., & Chiesa, C. (1995) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199507000-00005 · Cited by 35 · see citing works
Sanctis, V. D., D'Ascola, G., & Wonke, B. (1986) · Postgraduate Medical Journal · doi:10.1136/pgmj.62.731.831 · Cited by 34 · see citing works
Arber, N., Moshkowitz, M., Konikoff, F. M., Halpern, Z., Hallak, A., Santo, M., Tiomny, E., Baratz, M., & Gilat, T. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02063249 · Cited by 34 · see citing works
Iron and Chronic Viral Hepatitis: Emerging Evidence for an Important Interaction
Rubin, R. B., Barton, A. L., Banner, B. F., & Bonkovsky, H. L. (2008) · Digestive Diseases · doi:10.1159/000171504 · Cited by 34 · see citing works
A functional defect in hereditary haemochromatosis monocytes and monocyte‐derived macrophages
Moura, Verheul, & Marx, J. J. M. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00263.x · Cited by 30 · see citing works
Transfusion-associated iron overload
Hollán, S. R. (1997) · Current Opinion in Hematology · doi:10.1097/00062752-199704060-00014 · Cited by 26 · see citing works
Sackey, K. (1999) · Pediatrics in Review · doi:10.1542/pir.20-5-152 · Cited by 25 · see citing works
Serological monitoring of thalassaemia major patients for transfusion associated viral infections.
Choudhury, N., Saraswat, S., & Naveed, M. (1998) · PubMed · Cited by 24 · see citing works
Feng, X. B., Yang, X.-P., & Shen, J. (1994) · PubMed · Cited by 23 · see citing works
Salsaa, B., & Zoumbos, N. C. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.d01-962.x · Cited by 21 · see citing works
Thalassemia : pathophysiology and management
Fucharoen, S. (1988) · Alan R. Liss eBooks · Cited by 20 · see citing works
Assessment of Neutrophil Chemotaxis and Random Migration in Children with Thalassemia Major
Kütükçüler, N., Kutlu, O., Nişli, G., Öztop, S., Çetingül, N., & Çaǧlayan, S. (1996) · Pediatric Hematology and Oncology · doi:10.3109/08880019609030822 · Cited by 20 · see citing works
T Lymphocytes Subsets in Experimental Iron Overload
Cardier, J. E., Romano, E. L., & Sóyano, A. (1997) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979709038534 · Cited by 20 · see citing works
Erer, B., Angelucci, E., Lucarelli, G. T., Giardini, C., BARONCIANI, D., GALIMBERTI, M., Polchi, P., Amadei, G., Battistini, L., & Paolucci, S. (1994) · PubMed · Cited by 19 · see citing works
Lymphocytes in β‐thalassemia/HbE: subpopulations and mitogen responses
Wanachiwanawin, W., Phucharoen, J., Pattanapanyasat, K., Fucharoen, S., & Webster, H. K. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb01334.x · Cited by 18 · see citing works
Transfusion-dependent thalassemia: viral complications (epidemiology and follow-up).
de Montalembert, M., Girot, R., Mattlinger, B., & Lefrère, J. (1995) · PubMed · Cited by 18 · see citing works
ANTI-TRANSFERRIN RECEPTOR MONOCLONAL ANTIBODY
Woodward, J. E., Bayer, A. L., Chavin, K. D., Boleza, K. A., & Baliga, P. K. (1998) · Transplantation · doi:10.1097/00007890-199801150-00003 · Cited by 17 · see citing works
Transfusion-Related Immunomodulation in Chinese Children with Thalassaemia
Li, K., Li, C. K., Wong, R. P. O., Wong, A., Shing, M. M. K., Chik, K. W., & Yuen, P. M. P. (1997) · Vox Sanguinis · doi:10.1046/j.1423-0410.1997.7330167.x · Cited by 15 · see citing works
Fatal Campylobacter jejuni infection in a patient splenectomised for thalassaemia.
Jackson, N. M., Zaki, M. S., Rahman, A., Nazim, M. N., Win, M. N., & Osman, S. A. (1997) · Journal of Clinical Pathology · doi:10.1136/jcp.50.5.436 · Cited by 13 · see citing works
Trace Element and Mineral Nutrition in HIV Infection and AIDS
Cunningham–Rundles, S. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-040-7_19 · Cited by 12 · see citing works
Self-citationCardier, J. E., Romano, E. L., & Sóyano, A. (1995) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979509037190 · Cited by 12 · see citing works
Sackey, K. (1999) · Pediatrics in Review · doi:10.1542/pir.20-6-204 · Cited by 11 · see citing works
Ts, H., Lammi, A. T., & Webster, B. (1994) · PubMed · Cited by 8 · see citing works
Roles of Trace Metals in the Maturation, Activation and Effector Functions of Immune Cells
Failla, M. L. (1998) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000059451 · Cited by 7 · see citing works
High prevalence of hepatitis G virus infection in multiply transfused children with thalassaemia
Poovorawan, Y., Theamboonlers, A., Chongsrisawat, V., Seksarn, P., & SIMMONDS, L. J. A. P. (1998) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1998.01552.x · Cited by 7 · see citing works
Zeromski, J., & Jeżewska, E. (1995) · Immunology Letters · doi:10.1016/0165-2478(94)00242-j · Cited by 7 · see citing works
New variant of MHC class II deficiency with interleukin-2 abnormality
Cunningham-Rundles, S., Yeger‐Arbitman, R., Nachman, S., Kaul, S., & Fotino, M. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90175-p · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Schaible, U. E., & Kaufmann, S. H. E. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1046 · Cited by 945 · see citing works
Mechanisms of nutrient modulation of the immune response
Cunningham–Rundles, S., McNeeley, D. F., & Moon, A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.04.036 · Cited by 535 · see citing works
Self-citationPathogenesis and treatment of anaemia of chronic disease
Weiß, G. (2002) · Blood Reviews · doi:10.1054/blre.2002.0193 · Cited by 276 · see citing works
Trace Elements and Host Defense: Recent Advances and Continuing Challenges
Failla, M. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1443s · Cited by 200 · see citing works
Non-infectious complications of transfusion therapy
Perrotta, P. L., & Snyder, E. L. (2001) · Blood Reviews · doi:10.1054/blre.2001.0151 · Cited by 186 · see citing works
Iron in the Tumor Microenvironment-Connecting the Dots
Pfeifhofer-Obermair, C., Tymoszuk, P., Petzer, V., Weiss, G., & Nairz, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00549 · Cited by 151 · see citing works
Anaemia in inflammatory rheumatic diseases
Weiss, G., & Schett, G. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.183 · Cited by 146 · see citing works
Golin, C. E., Earp, J. A., Tien, H. C., Stewart, P. W., Porter, C. Q., & Howie, L. J. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000219771.97303.0a · Cited by 144 · see citing works
Mahindra, A. K., Bolwell, B. J., Sobecks, R. M., Rybicki, L. A., Pohlman, B. L., Dean, R. M., Andresen, S., Sweetenham, J. W., Kalaycio, M. E., & Copelan, E. A. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07774.x · Cited by 97 · see citing works
Nevitt, T., & Thiele, D. J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001322 · Cited by 95 · see citing works
“These observations are consistent with reports of greater microbial burden in patients with Fe overload disease [15,18,19,20,21] and predict that mutations affecting macrophage Fe levels may not only compromise microbial containment, but may also dictate the dependence of microbes on distinct mechanisms of Fe uptake.”
BackgroundHealy, C. M., Muñoz‐Wolf, N., Strydom, J., Faherty, L., Williams, N. C., Kenny, S., Donnelly, S. C., & Cloonan, S. M. (2021) · Respiratory Research · doi:10.1186/s12931-021-01722-y · Cited by 89 · see citing works
The effect of iron overload on in vitro HIV-1 infection
Traoré, H. N., & Meyer, D. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.09.011 · Cited by 71 · see citing works
Alidoost, F., Gharagozloo, M., Bagherpour, B., Jafarian‐Dehkordi, A., Sajjadi, S. E., Hourfar, H., & Moayedi, B. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.04.004 · Cited by 70 · see citing works
Natural Antioxidants in Anemia Treatment
Cotoraci, C. A., Ciceu, A., Sasu, A., & Hermenean, A. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041883 · Cited by 69 · see citing works
Thalassemia: current approach to an old disease
Lo, L., & Singer, S. T. (2002) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(02)00088-3 · Cited by 61 · see citing works
Activated peripheral blood and endothelial cells in thalassemia patients
Kyriakou, D. S., Alexandrakis, M. G., Kyriakou, E. S., Liapi, D., Kourelis, T., Passam, F. H., & Papadakis, A. (2001) · Annals of Hematology · doi:10.1007/s002770100355 · Cited by 61 · see citing works
The struggle for iron: gastrointestinal microbes modulate the host immune response during infection
Markel, T. A., Crisostomo, P. R., Wang, M., Herring, C. M., Meldrum, K. K., Lillemoe, K. D., & Meldrum, D. R. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906579 · Cited by 57 · see citing works
Iron Metabolism and the Inflammatory Response
Martins, A. C., Almeida, J. I., Lima, I. S., Kapitão, A., & Gozzelino, R. (2017) · IUBMB Life · doi:10.1002/iub.1635 · Cited by 52 · see citing works
Iron regulates T-lymphocyte sensitivity to the IFN-γ/STAT1 signaling pathway in vitro and in vivo
Regis, G., Bosticardo, M., Conti, L., De Angelis, S., Boselli, D., Tomaino, B., Bernabei, P., Giovarelli, M., & Novelli, F. (2005) · Blood · doi:10.1182/blood-2004-07-2686 · Cited by 50 · see citing works
Gharagozloo, M., Karimi, M., & Amirghofran, Z. (2008) · Annals of Hematology · doi:10.1007/s00277-008-0564-y · Cited by 48 · see citing works
Nickel, R. S., Osunkwo, I., Garrett, A. P., Robertson, J. M., Archer, D. R., Promislow, D., Horan, J., Hendrickson, J. E., & Kean, L. S. (2015) · British Journal of Haematology · doi:10.1111/bjh.13326 · Cited by 45 · see citing works
Role of nutrients in the development of neonatal immune response
Cunningham–Rundles, S., Lin, H., Lin, D. H., Dnistrian, A. M., Cassileth, B. R., & Perlman, J. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00236.x · Cited by 45 · see citing works
Self-citationCollard, K. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.04.046 · Cited by 48 · see citing works
Cooper, H. L. F., Brady, J. E., Friedman, S. R., Tempalski, B. J., Gostnell, K., & Flom, P. L. (2008) · Journal of Urban Health · doi:10.1007/s11524-008-9304-9 · Cited by 37 · see citing works
Immunomodulatory effects of silymarin in patients with β-thalassemia major
Gharagozloo, M., Karimi, M., & Amirghofran, Z. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.04.016 · Cited by 37 · see citing works
Mair, S. M., Nairz, M., Bellmann-Weiler, R., Muehlbacher, T., Schroll, A., Theurl, I., Moser, P. L., Talasz, H., Fang, F. C., & Weiss, G. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir395 · Cited by 33 · see citing works
SIVGIN, S., Baldane, S., Kaynar, L., Kurnaz, F., Pala, Ç., OZTURK, A., CETIN, M., Ünal, A., & Eser, B. (2011) · Neoplasma · doi:10.4149/neo_2012_024 · Cited by 33 · see citing works
Iron supplementation in the intensive care unit: when, how much, and by what route?
Lapointe, M. (2004) · Critical Care · doi:10.1186/cc2825 · Cited by 32 · see citing works
Barton, J. C., Wiener, H. W., Acton, R. T., & Go, R. C. P. (2005) · BMC Hematology · doi:10.1186/1471-2326-5-5 · Cited by 31 · see citing works
Darvishi‐Khezri, H., Salehifar, E., Kosaryan, M., Aliasgharian, A., Jalali, H., & Amree, A. H. (2016) · Advances in Pharmacological Sciences · doi:10.1155/2016/3046373 · Cited by 30 · see citing works
Silibinin: an old drug for hematological disorders
Zou, H., Zhu, X., Zhang, G., Ma, Y., Wu, Y. P., & Huang, D. (2017) · Oncotarget · doi:10.18632/oncotarget.19153 · Cited by 30 · see citing works
Snyder, J. A., Weston, A., Tinkle, S. S., & Demchuk, E. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6327 · Cited by 24 · see citing works
Nutrition in health and immune function of ruminants
Paul, S. S., & Dey, A. (2015) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v85i2.46557 · Cited by 23 · see citing works
Karimi, M., & Sanctis, V. D. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i2.9592 · Cited by 20 · see citing works
Whiteside, D. P., Barker, I. K., Mehren, K. G., Jacobs, R. M., & Conlon, P. D. (2004) · Journal of Zoo and Wildlife Medicine · doi:10.1638/02-031 · Cited by 20 · see citing works
Molecular mechanisms in allergy and clinical immunology
Shearer, W. T., Rosenwasser, L. J., Bochner, B. S., Gern, J. E., Rosenthal, L. A., Sorkness, R. L., & Lemanske, R. F. (2005) · Cited by 19 · see citing works
Emergence of the Molds Other than Aspergillus in Immunocompromised Patients
Arif, S., & Perfect, J. R. (2017) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2017.04.014 · Cited by 16 · see citing works
Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines
Jeon, S.-R., Lee, J. W., Jang, P., Chung, N., Cho, B., & Jeong, D.-C. (2015) · Blood Research · doi:10.5045/br.2015.50.1.33 · Cited by 14 · see citing works
Malnutrition and host defense.
Cunningham-Rundles, S., Moon, A., McNeeley, D. F., Duggan, C., Watkins, J. B., & Walker, W. A. (2003) · Cited by 14 · see citing works
Self-citationAl-Awadhi, A. M., AlFadhli, S. M., AL‐KHALDI, D., BORHAMA, M., & BORUSLY, M. (2009) · International Journal of Laboratory Hematology · doi:10.1111/j.1751-553x.2009.01161.x · Cited by 14 · see citing works
Wróblewska, A., Bernat, A., Woziwodzka, A., Markiewicz, J., Romanowski, T., Bielawski, K. P., Smiatacz, T., & Sikorska, K. (2016) · Clinical and Experimental Medicine · doi:10.1007/s10238-016-0423-4 · Cited by 13 · see citing works
Udnaen, S., Tansit, T., Kanistanon, D., Chaiprasert, A., Wanachiwanawin, W., & Srinoulprasert, Y. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.02.002 · Cited by 12 · see citing works
Baharlou, R., Davami, M. H., Vasmehjani, A. A., & EBRAHIMI, M. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1409-57 · Cited by 11 · see citing works
Papel del hierro en la interacción entre el huésped y el patógeno
Rueda, A. D. C., & Khosravi‐Shahi, P. (2009) · Medicina Clínica · doi:10.1016/j.medcli.2009.11.012 · Cited by 11 · see citing works
Darvishi‐Khezri, H., Kosaryan, M., Karami, H., Salehifar, E., Mahdavi, M., Alipour, A., & Aliasgharian, A. (2020) · Complementary Medicine Research · doi:10.1159/000509829 · Cited by 9 · see citing works
Immunoglobulin levels and CD4 / CD8 counts in β — Thalassemia major
Kadam, P. P., Manglani, M. V., Sharma, S., Sharma, R. A., & Setia, M. S. (2014) · Indian Pediatrics · doi:10.1007/s13312-014-0546-1 · Cited by 8 · see citing works
Siagris, D., Giannakoulas, N. C., Christofidou, M., Tsamandas, A. C., Lekkou, A., Thomopoulos, K., Zoumbos, N. C., & Labropoulou‐Karatza, C. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0919.x · Cited by 7 · see citing works
Pharmacokinetic Disposition of the Oral Iron Chelator Deferiprone in the White Leghorn Chicken
Whiteside, D. P., Barker, I. K., Conlon, P. D., Tesoro, A., Thiessen, J. J., Mehren, K. G., Jacobs, R. M., & Spino, M. (2007) · Journal of Avian Medicine and Surgery · doi:10.1647/1082-6742(2007)21[110:pdotoi]2.0.co;2 · Cited by 7 · see citing works
Vitamins as Nutraceuticals for Anemia
Pawar, S. D., Deore, S. D., Bairagi, N. P., Deshmukh, V. B., Lokhande, T. N., & Surana, K. R. (2023) · doi:10.1002/9781394175543.ch11 · Cited by 7 · see citing works
Immunological evaluation of β-thalassemia major patients receiving oral iron chelator deferasirox.
Aleem, A., Shakoor, Z. A., Alsaleh, K. A., AlGahtani, F. H., Iqbal, Z., & Al-Momen, A. (2014) · PubMed · Cited by 6 · see citing works
Sumera, A., Anuar, N. D., Radhakrishnan, A. K., Ibrahim, H. M., Rutt, N. H., Ismail, N. H., Tan, T., & Baba, A. A. (2020) · Biomedicines · doi:10.3390/biomedicines8050097 · Cited by 6 · see citing works
Impact of initial serum ferritin on early post-HSCT complications: a single-center study
Shaheen, M. M., Ivanova, M. O., Moiseev, I., Afanasyev, B. V., & Bondarchuk, S. V. (2016) · Cellular Therapy and Transplantation · doi:10.18620/1866-8836-2016-5-2-40-49 · Cited by 5 · see citing works
Dysregulated Serum Cytokine Production in Pediatric Patients with β-Thalassemia Major
Zhang, L., Bao, L., Hong, Z., Yan, M., Zhang, Z.-H., Li, Y., Ye, Q., & Wang, Y. (2022) · Hemoglobin · doi:10.1080/03630269.2022.2070499 · Cited by 5 · see citing works
Chung, H., Hsieh, T.-C., Yu, M., Chang, Y., Lo, W.-C., & Jaing, T. (2007) · Pediatric Hematology and Oncology · doi:10.1080/08880010701364249 · Cited by 5 · see citing works
Hamidieh, A. A., Tayebi, S., Moeininia, F., Shamshiri, A. R., Behfar, M., Alimoghaddam, K., & Ghavamzadeh, A. (2014) · Hematology/Oncology and Stem Cell Therapy · doi:10.1016/j.hemonc.2014.06.002 · Cited by 5 · see citing works
Nafady, A., NasrEldin, E., Nafady‐Hego, H., Nasif, K. A., Abd-Elmawgoud, E., & Sayed, M. M. (2018) · The Egyptian Journal of Haematology · doi:10.4103/ejh.ejh_3_18 · Cited by 4 · see citing works
Zhou, Y., & Luo, J. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.939157 · Cited by 4 · see citing works
Nutritional and stress effects on immunologic function
Lehman, H. K., & Ballow, M. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816768-7.00047-8 · Cited by 3 · see citing works
Donor-Specific Blood Transfusion in Lung Transplantation
Jin, X., Pirenne, J., Vos, R., Hooft, C., Kaes, J., Slambrouck, J. V., Kortleven, P., Vandervelde, C. M., Beeckmans, H., Kerckhof, P., et al. (2024) · Transplant International · doi:10.3389/ti.2024.12822 · Cited by 3 · see citing works
Elaziz, A. A. (2015) · Journal of Blood Disorders & Transfusion · doi:10.4172/2155-9864.1000273 · Cited by 2 · see citing works
Assessment of Human Immune Response
Cunningham–Rundles, S. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-652-2_2 · Cited by 2 · see citing works
Self-citationSeng dan Respons Imun pada Talasemia
Sari, T. T. (2016) · Sari Pediatri · doi:10.14238/sp18.2.2016.157-63 · Cited by 1 · see citing works
Tang, X., Fang, M., Xu, K., Cheng, R., Wang, G., Liao, Z., Zhang, Z., Mwangi, J., Lu, Q., & Lai, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.02.972281 · Cited by 1 · see citing works
Nutrition education material to address iron deficiency anemia in Kenya
Kakunted, P. (2008) · doi:10.31979/etd.xdx7-hqmm · Cited by 1 · see citing works
Araújo, A. P. (2007) · Americanae (AECID Library)
Munasir, Z., Ruth, A. D., & Tumbelaka, A. R. (2016) · Paediatrica Indonesiana · doi:10.14238/pi43.6.2003.216-9
Adib, M., Ghatrehsamani, M., Soleimani, M., Esfahani, B. A.-S. M., Ganjalıkhani-Hakemi, M., Shirzad, H., & Eskandari, N. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.166165
Puertollano, E., & Puertollano, M. A. (2014) · CRC Press eBooks · doi:10.1201/b17311-6
Hepatitis C pada Thalassemia mayor: pengaruh Iron Overload pada perjalanan penyakit
Damardjati, F., & Oswari, H. (2016) · Sari Pediatri · doi:10.14238/sp5.1.2003.16-20
Snyder, J. A., Weston, A., Tinkle, S. S., & Demchuk, E. (2003) · Environmental Health Perspectives · doi:10.1289/txg.6327
- Authors
- Cunningham‐Rundles, S., Giardina, P. J., Grady, R. W., Califano, C., McKenzie, P., & De Sousa, M.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- ORCID
- Califano, Claudia
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 182
- Issue
- s1
- Pages
- S115-S121
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2104522851
- Cited by
- 71
- References
- 71
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- Weill Cornell Medical College
- National Cancer Institute (CA-29502)
- National Center for Research Resources (RR6020)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- transfusional iron overload, transfusion-dependent thalassemia, CD8+ T cells, CD4+ T cells, immunophenotype, deferoxamine, chelation therapy, infection susceptibility, T cell proliferation, chronic immune stimulation
- MeSH terms
- Adolescent, Adult, Chelating Agents, Child, Child, Preschool, Deferoxamine, Female, Greece, Humans, Italy, Male, Middle Aged, New York City, Immunophenotyping, T-Lymphocyte Subsets, beta-Thalassemia, CD8-Positive T-Lymphocytes, Iron Overload, White People, Transfusion Reaction
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