Iron in the Tumor Microenvironment-Connecting the Dots

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

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The chemokine system in diverse forms of macrophage activation and polarization

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Macrophage plasticity and polarization: in vivo veritas

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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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Ferroptosis as a p53-mediated activity during tumour suppression

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Alternative Activation of Macrophages: An Immunologic Functional Perspective

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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Distinct role of macrophages in different tumor microenvironments

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

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The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

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Ferroptosis is an autophagic cell death process

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VEGF as a Key Mediator of Angiogenesis in Cancer

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Identification of the haemoglobin scavenger receptor

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

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Iron-Deficiency Anemia

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Iron and cancer: more ore to be mined

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Inflammation meets cancer, with NF-κB as the matchmaker

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Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis

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A Red carpet for iron metabolism

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Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Identification of erythroferrone as an erythroid regulator of iron metabolism

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Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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Iron metabolism and toxicity

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Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

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Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

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Macrophage defense mechanisms against intracellular bacteria

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Interleukin-6 induces hepcidin expression through STAT3

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Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury

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Anemia as an independent prognostic factor for survival in patients with cancer

Caro, J. J., Salas, M., Ward, A., & Goss, G. D. (2001) · Cancer · doi:10.1002/1097-0142(20010615)91:12 · Cited by 947 · see citing works

Iron and microbial infection

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Advances in Hypoxia-Inducible Factor Biology

Choudhry, H., & Harris, A. L. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.005 · Cited by 873 · see citing works

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854 · see citing works

Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review.

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The role of myeloid cells in cancer therapies

Engblom, C., Pfirschke, C., & Pittet, M. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.54 · Cited by 788 · see citing works

The Intestinal Microbiota in Colorectal Cancer.

Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777 · cited 1× · see citing works

Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

Ohgami, R. S., Campagna, D. R., Greer, E. L., Antiochos, B., McDonald, A., Chen, J., Sharp, J. J., Fujiwara, Y., Barker, J. E., & Fleming, M. D. (2005) · Nature Genetics · doi:10.1038/ng1658 · Cited by 775 · see citing works

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

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Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

Goswami, S. K., Sahai, E. A., Wyckoff, J. B., Cammer, M., Cox, D., Pixley, F. J., Stanley, E. R., Segall, J. E., & Condeelis, J. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1853 · Cited by 739 · see citing works

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701 · see citing works

Iron and Its Relation to Immunity and Infectious Disease

Oppenheimer, S. J. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.616s · Cited by 695 · see citing works

The two faces of IL-6 in the tumor microenvironment

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Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression

DeNardo, D. G., & Coussens, L. M. (2007) · Breast Cancer Research · doi:10.1186/bcr1746 · Cited by 677 · see citing works

A Cell-Surface Receptor for Lipocalin 24p3 Selectively Mediates Apoptosis and Iron Uptake

Devireddy, L. R., Gazin, C., Zhu, X., & Green, M. R. (2005) · Cell · doi:10.1016/j.cell.2005.10.027 · Cited by 672 · see citing works

Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

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Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

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Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

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Iron Fortification Adversely Affects the Gut Microbiome, Increases Pathogen Abundance and Induces Intestinal Inflammation in Kenyan Infants

Jaeggi, T., Kortman, G. A. M., Moretti, D., Chassard, C., Holding, P., Dostal, A., Boekhorst, J., Timmerman, H. M., Swinkels, D. W., Tjalsma, H., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307720 · Cited by 622 · see citing works

ROS, stress‐activated kinases and stress signaling in cancer

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Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials

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Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide

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Characterization of Heme as Activator of Toll-like Receptor 4

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Body Iron Stores and the Risk of Cancer

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STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

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Tumor-associated macrophages: Functional diversity, clinical significance, and open questions

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Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron

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Regulation of hepcidin transcription by interleukin-1 and interleukin-6

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A cytosolic iron chaperone that delivers iron to ferritin

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Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes.

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The Effects of Iron Fortification on the Gut Microbiota in African Children: A Randomized Controlled Trial in Cote d’Ivoire

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The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

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Iron, anaemia, and inflammatory bowel diseases

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Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin

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Anemia at older age: etiologies, clinical implications, and management

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Labile plasma iron in iron overload: redox activity and susceptibility to chelation

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Identification of the receptor scavenging hemopexin-heme complexes

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KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

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The role of iron in cell cycle progression and the proliferation of neoplastic cells

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Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

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Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

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Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD

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Differential regulation of iron homeostasis during human macrophage polarized activation

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Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

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Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

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Proinflammatory Cytokines Lowering Erythropoietin Production

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Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

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Cytokine-mediated regulation of iron transport in human monocytic cells

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On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

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Detection, evaluation, and management of iron-restricted erythropoiesis

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The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress

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Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection

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The struggle for iron - a metal at the host-pathogen interface: Iron at the host-pathogen interface

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Intravital imaging of metastatic behavior through a mammary imaging window

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Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

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Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker

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The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

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Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis

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Iron inhibits glioblastoma cell migration and polarization

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The role of ferroptosis‐related genes for overall survival prediction in breast cancer

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Orchestrated Action of AMPK Activation and Combined VEGF/PD-1 Blockade with Lipid Metabolic Tunning as Multi-Target Therapeutics against Ovarian Cancers

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Yeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism

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Lactoferrin—A Regulator of Iron Homeostasis and Its Implications in Cancer

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Inflammation Mediated Hepcidin-Ferroportin Pathway and Its Therapeutic Window in Breast Cancer

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Upregulated Expression of CYBRD1 Predicts Poor Prognosis of Patients with Ovarian Cancer

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The dual role of vitamin C in cancer: from antioxidant prevention to prooxidant therapeutic applications

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Article review: Brazilin as potential anticancer agent

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The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways

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Iron deficiency downregulates ENPEP to promote angiogenesis in liver tumors

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The role of heme in environmentally caused oncogenesis (review)

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Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model

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Mechanism and role of ferroptosis in the development of gastric cancer

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Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

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Immune Escape in Prostate Cancer

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Targeting emerging cancer hallmarks by transition metal complexes: Cancer stem cells and tumor microbiome. Part I

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Ferroptosis-Related Gene Signature and Patterns of Immune Infiltration Predict the Overall Survival in Patients With Lung Adenocarcinoma

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Ferroptosis in eye diseases: a systematic review

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A Novel Ferroptosis-Related Gene Signature to Predict Prognosis in Patients with Head and Neck Squamous Cell Carcinoma

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MR susceptibility imaging for detection of tumor-associated macrophages in glioblastoma

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Study of Essential and Toxic Metal Imbalances in the Scalp Hair of Thyroid Cancer Patients in Comparison with Healthy Donors

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ROS-catalytic self-amplifying benzothiophenazine-based photosensitive conjugates for photodynamic-immuno therapy

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Exogenous Ascorbate Administration Elevates Testicular Oxidative Damage and Histological Injuries in Rats after Busulfan Treatment

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Anaesthesia as an influence in tumour progression

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Ferroptosis in Cancer Immunotherapy—Implications for Hepatocellular Carcinoma

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Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma

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A Nomogram Based on Circulating CD4+ T Lymphocytes and Lactate Dehydrogenase to Predict Distant Metastasis in Patients with Nasopharyngeal Carcinoma

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Ferroptosis: A potential opportunity for intervention of pre-metastatic niche

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Modulation of the Immune Response by Deferasirox in Myelodysplastic Syndrome Patients

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Beyond Iron: The Roles of CD71 in the Pathophysiology of Cancer—A Comprehensive Review

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Iron Regulates Cellular Proliferation by Enhancing the Expression of Glucose Transporter GLUT3 in the Liver

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The iron chelator deferoxamine decreases myeloma cell survival

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What Is the Correlation between Preeclampsia and Cancer? The Important Role of Tachykinins and Transition Metal Ions

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Mentzer Index in breast cancer: Insights into anemia and tumor progression – a narrative review

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Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model

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Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response

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Iron as a central player and promising target in cancer progression

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Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment

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Iron metabolism and the tumor microenvironment: A new perspective on cancer intervention and therapy (Review)

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Iron metabolism and its contribution to cancer (Review)

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