Ophthalmologic, Visceral, and Cardiac Involvement in Neonates with Candidemia

Noyola, D. E.; Fernandez, M.; Moylett, E. H.; Baker, C. J.

doi:10.1086/319601

Cited by 137Antifungal resistance and susceptibilityOcular Infections and TreatmentsNeonatal and Maternal Infections

Ophthalmologic, Visceral, and Cardiac Involvement in Neonates with Candidemia

Noyola, D. E., Fernandez, M., Moylett, E. H., Baker, C. J.·2001·Clinical Infectious Diseases

DOI 10.1086/319601

Open this paper in CoChat — free account

Abstract

A retrospective review of 86 neonates with candidemia hospitalized from January 1989 through June 1999 was conducted to determine the frequency of ophthalmologic, visceral, or cardiac involvement. Retinal abnormalities were observed in 4 (6%) of the 67 infants in whom indirect ophthalmoscopy examination was performed. Abdominal ultrasound abnormalities were detected in 5 (7.7%) of 65 infants. Echocardiogram revealed thrombi or vegetations in 11 (15.2%) of 72 infants. Age at onset, presence of central venous catheters, and species of Candida were not predictors for involvement at these sites. Infants with candidemia that lasted > or =5 days were more likely to demonstrate ophthalmologic, renal, or cardiac abnormalities than those with a shorter duration. Infants with involvement of these organs received larger cumulative doses of amphotericin B than those without detectable abnormalities. Because complication of disseminated candidiasis by eye, renal, or cardiac involvement has therapeutic implications, and because risk factors for candidemia inadequately predict these complications, evaluations are indicated for all neonates with candidemia.

Integrity signals

Registry

Crossref · 10.1086/319601

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In neonates, a duration of candidemia of at least 5 days has been linked to the likelihood of ophthalmologic, renal, and cardiac involvement.
“In neonates, a duration of candidemia of у5 days has been linked to the likelihood of ophthalmologic, renal, and cardiac involvement [114].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [114]

Late-onset sepsis in very low birth weight neonates: A report from the National Institute of Child Health and Human Development Neonatal Research Network
Stoll, B. J., Gordon, T., Korones, S. B., Shankaran, S., Tyson, J. E., Bauer, C. R., Fanaroff, A. A., Lemons, J. A., Donovan, E. F., Oh, W., et al. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)70191-9 · Cited by 871 · see citing works
Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases
KOSSOFF, E. H., BUESCHER, E. S., & KARLOWICZ, M. G. (1998) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199806000-00014 · Cited by 330 · see citing works
Disseminated Fungal Infections in Very Low-Birth-Weight Infants: Clinical Manifestations and Epidemiology
Baley, J. E., Kliegman, R. M., & Fanaroff, A. A. (1984) · PEDIATRICS · doi:10.1542/peds.73.2.144 · Cited by 276 · see citing works
Risk factors associated with candidemia in the neonatal intensive care unit
Weese‐Mayer, D. E., Fondriest, D. W., Brouillette, R. T., & Shulman, S. T. (1987) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198702000-00009 · Cited by 197 · see citing works
Candidal Meningitis in Neonates: A 10-Year Review
Fernandez, M., Moylett, E. H., Noyola, D. E., & Baker, C. J. (2000) · Clinical Infectious Diseases · doi:10.1086/313973 · Cited by 163 · see citing works
Systemic Candida infections in infants in intensive care nurseries: High incidence of central nervous system involvement
Faix, R. G. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80433-3 · Cited by 162 · see citing works
Candidal infection in the central nervous system
Lipton, S. A., Hickey, W. F., Morris, J. H., & Loscalzo, J. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90757-5 · Cited by 157 · see citing works
Invasive Fungal Dermatitis in the ≤1000-Gram Neonate
Rowen, J. L., Atkins, J. T., Levy, M. L., Baer, S. C., & Baker, C. J. (1995) · PEDIATRICS · doi:10.1542/peds.95.5.682 · Cited by 156 · see citing works
Adherence and penetration of vascular endothelium by Candida yeasts
Klotz, S. A., Drutz, D. J., Harrison, J. L., & Huppert, M. (1983) · Infection and Immunity · doi:10.1128/iai.42.1.374-384.1983 · Cited by 136 · see citing works
Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection
FAIX, R. G. (1992) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199202000-00006 · Cited by 122 · cited 3× · see citing works
“Renal involvement, including fungus ball uropathy and renal parenchymal infiltration, was described by Faix [17] in 26% of 45 infants with systemic candidiasis and in 33% of 30 candidemic infants reported by Benjamin et al. [22].”
BackgroundInfluential
CandidaSepsis and Association With Retinopathy of Prematurity
Mittal, M., Dhanireddy, R., & Higgins, R. D. (1998) · PEDIATRICS · doi:10.1542/peds.101.4.654 · Cited by 118 · see citing works
Neonatal Candidiasis: The Current Challenge
Baley, J. E. (1991) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30523-2 · Cited by 118 · see citing works
Thrombus Detection on Central Venous Catheters in the Neonatal Intensive Care Unit
Tanke, R. B., van Megen, R., & Daniëls, O. (1994) · Angiology · doi:10.1177/000331979404500610 · Cited by 104 · see citing works
Management of neonatal candidiasis
Rowen, J. L., & Tate, J. M. (1998) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199811000-00008 · Cited by 97 · see citing works
Comparative Study of Mortality and Morbidity in Premature Infants (Birth Weight, <1,250 g) with Candidemia or Candidal Meningitis
Lee, B. E., Cheung, P., Robinson, J. L., Evanochko, C., & Robertson, C. M. T. (1998) · Clinical Infectious Diseases · doi:10.1086/514712 · Cited by 97 · see citing works
Candida endophthalmitis in the premature infant
Baley, J. E., Annable, W. L., & Kliegman, R. M. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80722-6 · Cited by 86 · see citing works
Amphotericin B as a single agent in the treatment of systemic candidiasis in neonates
BUTLER, K. M., Rench, M. A., & Baker, C. J. (1990) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199001000-00012 · Cited by 85 · see citing works
Renal candidiasis in neonates with candiduria
BRYANT, K., MAXFIELD, C., & RABALAIS, G. (1999) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199911000-00004 · Cited by 83 · see citing works
Systemic candidiasis: a study of 109 fatal cases.
Hughes, W. T. (1983) · PubMed · Cited by 74 · see citing works
Systemic candidiasis
Hughes, W. T. (1982) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198201000-00005 · Cited by 65 · see citing works
Candidal Mycetoma in the Neonatal Kidney
Benjamin, D. K., Fisher, R. G., McKinney, R. E., & Benjamin, D. K. (1999) · PEDIATRICS · doi:10.1542/peds.104.5.1126 · Cited by 56 · see citing works
Candida meningitis in newborn infants: a review and report of combined amphotericin B--flucytosine therapy.
Chesney, P. J., Justman, R. A., & Bogdanowicz, W. M. (1978) · PubMed · Cited by 48 · see citing works
Successful medical treatment of presumed Candida endocarditis in critically ill infants
Zenker, P. N., Rosenberg, E. M., Dyke, R. B. V., Rabalais, G. P., & Daum, R. S. (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)82067-0 · Cited by 45 · see citing works
Fungal Endocarditis in Premature Infants: Case Report and Review
Mayayo, E., Moralejo, J., Camps, J., & Guarro, J. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.2.366 · Cited by 42 · see citing works
Candida endocarditis
Sánchez, P. J., Siegel, J. D., & FISHBEIN, J. T. (1991) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199103000-00013 · Cited by 40 · see citing works
Bladder Fungus Ball: A Reversible Cause of Neonatal Obstructive Uropathy
Baetz-Greenwalt, B., Debaz, B. P., & KUMAR, M. L. (1988) · PEDIATRICS · doi:10.1542/peds.81.6.826 · Cited by 39 · see citing works
Primary Renal Candidiasis in Two Preterm Neonates
Pappu, L. D. (1984) · American journal of diseases of children · doi:10.1001/archpedi.1984.02140480025009 · Cited by 37 · see citing works
Short-Course Amphotericin B Therapy for Candidemia in Pediatric Patients
Donowitz, L. G., & Hendley, J. O. (1995) · PEDIATRICS · doi:10.1542/peds.95.6.888 · Cited by 30 · see citing works
Endogenous candidal endophthalmitis.
Deutsch, D., Adler, S., Teller, J., & Savir, H. (1989) · PubMed · Cited by 16 · see citing works

Flagged first, then by citations

Sorted by citations

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
A Prospective Observational Study of Candidemia: Epidemiology, Therapy, and Influences on Mortality in Hospitalized Adult and Pediatric Patients
Pappas, P. G., Rex, J. H., Lee, J., Hamill, R. J., Larsen, R. A., Powderly, W. G., Kauffman, C. A., Hyslop, N., Mangino, J. E., Chapman, S. W., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/376906 · Cited by 832 · see citing works
Changes in the epidemiological landscape of invasive candidiasis
Lamoth, F., Lockhart, S. R., Berkow, E. L., & Calandra, T. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx444 · Cited by 547 · see citing works
Changing patterns and trends in systemic fungal infections
Richardson, M. D. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki218 · Cited by 525 · see citing works
Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants
Kaufman, D. A., & Fairchild, K. D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.638-680.2004 · Cited by 433 · see citing works
Neonatal sepsis: Progress towards improved outcomes
Shane, A. L., & Stoll, B. J. (2013) · Journal of Infection · doi:10.1016/j.jinf.2013.09.011 · Cited by 296 · see citing works
Neonatal Candidemia and End-Organ Damage: A Critical Appraisal of the Literature Using Meta-analytic Techniques
Benjamin, D. K., Poole, C., Steinbach, W. J., Rowen, J. L., & Walsh, T. J. (2003) · PEDIATRICS · doi:10.1542/peds.112.3.634 · Cited by 232 · see citing works
Candida parapsilosis Is a Significant Neonatal Pathogen: A Systematic Review and Meta-analysis
Pammi, M., Holland, L., Butler, G., Gacser, A., & Bliss, J. M. (2013) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182863a1c · Cited by 206 · see citing works
Risk Factors for Disseminated Candidiasis in Children with Candidemia
Zaoutis, T. E., Grow, H. M., Lautenbach, E., Bilker, W. B., & Coffin, S. E. (2004) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000128781.77600.6f · Cited by 166 · see citing works
Fluconazole Prophylaxis in Extremely Low Birth Weight Neonates Reduces Invasive Candidiasis Mortality Rates Without Emergence of Fluconazole-Resistant Candida Species
Healy, C. M., Campbell, J. R., Zaccaria, E., & Baker, C. J. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1130 · Cited by 149 · see citing works
Recent Developments and Current Issues in the Epidemiology, Diagnosis, and Management of Bacterial and Fungal Neonatal Sepsis
Stoll, B. J., & Shane, A. L. (2013) · American Journal of Perinatology · doi:10.1055/s-0032-1333413 · Cited by 147 · see citing works
Impact of Fluconazole Prophylaxis on Incidence and Outcome of Invasive Candidiasis in a Neonatal Intensive Care Unit
Healy, C. M., Baker, C. J., Zaccaria, E., & Campbell, J. R. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.04.016 · Cited by 122 · see citing works
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Thompson, G. R., Jenks, J. D., Baddley, J. W., Lewis, J. S., Egger, M., Schwartz, I. S., Boyer, J., Patterson, T. F., Chen, S. C. ‐., Pappas, P. G., et al. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00019-23 · Cited by 128 · see citing works
Experience with Caspofungin in the Treatment of Persistent Fungemia in Neonates
Natarajan, G., Lulic‐Botica, M., Rongkavilit, C., Pappas, A., & Bedard, M. P. (2005) · Journal of Perinatology · doi:10.1038/sj.jp.7211380 · Cited by 109 · see citing works
Polymicrobial bloodstream infections in the neonatal intensive care unit are associated with increased mortality: a case-control study
Pammi, M., Zhong, D.-N., Johnson, Y., Revell, P. A., & Versalovic, J. A. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-390 · Cited by 99 · see citing works
Candida infections in the neonate
Chapman, R. L. (2003) · Current Opinion in Pediatrics · doi:10.1097/00008480-200302000-00016 · Cited by 80 · see citing works
Fungal Endocarditis in Neonates and Children
Millar, B. C., Jugo, J., & Moore, J. E. (2004) · Pediatric Cardiology · doi:10.1007/s00246-004-0831-1 · Cited by 75 · see citing works
Invasive fungal infections in neonates: a review
Weimer, K. E. D., Smith, P. B., Puia‐Dumitrescu, M., & Aleem, S. (2021) · Pediatric Research · doi:10.1038/s41390-021-01842-7 · Cited by 75 · see citing works
Fungal infection in the very low birthweight infant
Kaufman, D. A. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200406000-00014 · Cited by 70 · see citing works
Persistent candidemia in neonatal care units: risk factors and clinical significance
Hammoud, M. S., Al-Taiar, A., Fouad, M., Raina, A., & Khan, Z. (2013) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.11.020 · Cited by 63 · see citing works
Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children
King, J., Pana, Z. D., Lehrnbecher, T., Steinbach, W. J., & Warris, A. (2017) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/pix053 · Cited by 70 · see citing works
Strategies for prevention of neonatal invasive candidiasis
Kaufman, D. A. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00067-3 · Cited by 64 · see citing works
Novel synergistic antibiofilm combinations for salvage of infected catheters
Venkatesh, M. P., Rong, L., RAAD, I. I., & Versalovic, J. A. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.009761-0 · Cited by 68 · see citing works
Candida bloodstream infection in neonates
Benjamin, D. K., Garges, H. P., & Steinbach, W. J. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00061-2 · Cited by 64 · see citing works
Challenging issues in neonatal candidiasis
Kaufman, D. A. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.487799 · Cited by 66 · see citing works
Prevention and Treatment of Candida Infections in Neonates
Chapman, R. L. (2007) · Seminars in Perinatology · doi:10.1053/j.semperi.2007.01.006 · Cited by 63 · see citing works
Candidal renal and urinary tract infection in neonates
Karlowicz, M. G. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00063-6 · Cited by 64 · see citing works
Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study
Robinson, J. L., Davies, H. D., Barton, M., O’Brien, K., Simpson, K., Asztalos, E. V., Synnes, A. R., Rubin, E., Saux, N. L., Hui, C. P., et al. (2009) · BMC Infectious Diseases · doi:10.1186/1471-2334-9-183 · Cited by 62 · see citing works
Ocular involvement in children with candidemia
Donahue, S. P., Hein, E., & Sinatra, R. B. (2003) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01705-1 · Cited by 56 · see citing works
Invasive candidiasis in pediatric intensive care units
Singhi, S. C., & Deep, A. (2009) · The Indian Journal of Pediatrics · doi:10.1007/s12098-009-0219-6 · Cited by 56 · see citing works
Effects of Fluid and Electrolyte Management on Amphotericin B-Induced Nephrotoxicity Among Extremely Low Birth Weight Infants
Holler, B., Omar, S. A., Farid, M. D., & Patterson, M. J. (2004) · PEDIATRICS · doi:10.1542/peds.113.6.e608 · Cited by 55 · see citing works
Neonatal candidiasis: ophthalmologic infection
Baley, J. E., & Ellis, F. J. (2003) · Seminars in Perinatology · doi:10.1016/s0146-0005(03)00064-8 · Cited by 54 · see citing works
Antifungal Agents in Neonates
Almirante, B., & Rodríguez-Pardo, D. (2007) · Pediatric Drugs · doi:10.2165/00148581-200709050-00004 · Cited by 49 · see citing works
Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis
Phongkhun, K., Pothikamjorn, T. L., Srisurapanont, K., Manothummetha, K., Sanguankeo, A., Thongkam, A., Chuleerarux, N., Leksuwankun, S., Meejun, T., Thanakitcharu, J., et al. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad064 · Cited by 47 · see citing works
Clinical characteristics and risk factors for mortality in adult patients with persistent candidemia
Kang, S., Kim, S. E., Kim, U. J., Jang, H., Park, K., Shin, J. H., & Jung, S. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.05.019 · Cited by 48 · see citing works
Persistent Candidemia in adults: underlying causes and clinical significance in the antifungal stewardship era
on behalf of the COMIC Study Group (Collaborative Group on Mycosis), Agnelli, C., Valerio, M., Bouza, E., Vena, A., Guinea, J., Martínez‐Jiménez, M. D. C., Marcos-Zambrano, L. J., Escribano, P., & Muñóz, P. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03477-3 · Cited by 47 · see citing works
Strategies for the Prevention of Neonatal Candidiasis
Leibovitz, E. (2012) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2012.01.004 · Cited by 46 · see citing works
Invasive Fungal Infections in Neonates in Canada
Ting, J. Y., Roberts, A. D., Synnes, A. R., Canning, R., Bodani, J., Monterossa, L., & Shah, P. S. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001968 · Cited by 41 · see citing works
Persistent Candidemia: Causes and Investigations
Nucci, M. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0039-1 · Cited by 36 · see citing works
Candidoses et levuroses diverses
Develoux, M., & Bretagne, S. (2005) · EMC-Maladies infectieuses/Encyclopédie médico-chirurgicale. Maladies infectieuses · doi:10.1016/j.emcmi.2005.04.001 · Cited by 32 · see citing works
Neonatal Coinfection Model of Coagulase-Negative Staphylococcus ( Staphylococcus epidermidis ) and Candida albicans : Fluconazole Prophylaxis Enhances Survival and Growth
Pammi, M., Pham, D., Fein, M., Kong, L., & Weisman, L. E. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01298-06 · Cited by 34 · see citing works
Recommendations for the management of candidemia in children in Latin America
Santolaya, M. E., Telles, F. D. Q., Matute, T. A., Colombo, A. L., Zurita, J., Tiraboschi, I. N., Cortés, J. A., Thompson-Moya, L., Guzmán-Blanco, M., Sifuentes‐Osornio, J., et al. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.05.010 · Cited by 34 · see citing works
FatalTrichodermaharzianuminfection in a leukemic pediatric patient
Kantarcıoğlu, A. S., Celkan, T. T., Yücel, A., Mikami, Y., Kuruğoğlu, S., Mitani, H., & Altaş, K. (2009) · Medical Mycology · doi:10.1080/13693780802406225 · Cited by 33 · see citing works
Invasive Candida infections in the neonate
Smith, P. B., Steinbach, W. J., & Benjamin, D. K. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2005.04.007 · Cited by 33 · see citing works
Incidence and predictors of invasive candidiasis associated with candidaemia in children
Festekjian, A., & Neely, M. N. (2009) · Mycoses · doi:10.1111/j.1439-0507.2009.01785.x · Cited by 32 · see citing works
Invasive fungal infections in newborns and current management strategies
Hundalani, S. G., & Pammi, M. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2013.811925 · Cited by 32 · see citing works
CLABSI reduction using evidence based interventions and nurse empowerment: a quality improvement initiative from a tertiary care NICU in Pakistan
Hussain, A. S., Ahmed, A. M., Arbab, S., Ariff, S., Ali, R., Demas, S., Zeb, J., Rizvi, A., Saleem, A. F., & Farooqi, J. Q. (2020) · Archives of Disease in Childhood · doi:10.1136/archdischild-2019-318779 · Cited by 31 · see citing works
Influence of sodium intake on Amphotericin B-induced nephrotoxicity among extremely premature infants
Turcu, R. M., Patterson, M. J., & Omar, S. A. (2008) · Pediatric Nephrology · doi:10.1007/s00467-008-1050-4 · Cited by 31 · see citing works
Antifungal prophylaxis in neonates
Manzoni, P., Jacqz-Aigrain, É., Rizzollo, S., Franco, C., Stronati, M., Mostert, M., & Farina, D. (2011) · Early Human Development · doi:10.1016/j.earlhumdev.2011.01.013 · Cited by 30 · see citing works
Review of Fluconazole Treatment and Prophylaxis for Invasive Candidiasis in Neonates
Hornik, C. D., Bondi, D. S., Greene, N. M., Cober, M. P., & John, B. M. (2021) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-26.2.115 · Cited by 29 · see citing works
Ocular Manifestations Of Candidemia In Children
Fierro, J. L., Prasad, P. A., Fisher, B. T., Gerber, J. S., Coffin, S. E., Walsh, T. J., & Zaoutis, T. E. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31826f547c · Cited by 29 · see citing works
Declining Incidence of Neonatal Endophthalmitis in the United States
Moshfeghi, A. A., Charalel, R. A., Hernandez‐Boussard, T., Morton, J. M., & Moshfeghi, D. M. (2010) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2010.07.008 · Cited by 28 · see citing works
Clinical practice
Bisht, V., & Voort, J. V. (2011) · European Journal of Pediatrics · doi:10.1007/s00431-011-1514-6 · Cited by 28 · see citing works
Candidemia in Children
Silvester, E. J., Watanabe, M., Pittet, L. F., Boast, A., Bryant, P. A., Haeusler, G. M., Daley, A. J., Curtis, N. C., & Gwee, A. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003082 · Cited by 27 · see citing works
Role of the Inducible Adhesin CpAls7 in Binding of Candida parapsilosis to the Extracellular Matrix under Fluid Shear
Neale, M. N., Glass, K., Longley, S., Kim, D. J., Laforce-Nesbitt, S., Wortzel, J. D., Shaw, S., & Bliss, J. (2018) · Infection and Immunity · doi:10.1128/iai.00892-17 · Cited by 24 · see citing works
Candidiasis
Vázquez, J. A., & Sobel, J. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6640-7_11 · Cited by 25 · see citing works
Invasive fungal infections during the neonatal period: diagnosis, treatment and prophylaxis
Tezer, H., Canpolat, F. E., & Dilmen, U. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.647685 · Cited by 24 · see citing works
Healthcare-Associated Infections in the Neonate
Sass, L. A., & Karlowicz, M. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-40181-4.00094-3 · Cited by 23 · see citing works
Very Low Prevalence of Endophthalmitis in Very Low Birthweight Infants who Survive Candidemia
Fisher, R. G., Karlowicz, M. G., & Lall-Trail, J. (2005) · Journal of Perinatology · doi:10.1038/sj.jp.7211300 · Cited by 20 · see citing works
Exacerbation of Invasive Candida albicans Infection by Commensal Bacteria or a Glycolipid Through IFN-γ Produced in Part by iNKT Cells
Tarumoto, N., Kinjo, Y., Kitano, N., Sasai, D., Ueno, K., Okawara, A., Izawa, Y., Shinozaki, M., Watarai, H., Taniguchi, M., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit534 · Cited by 20 · see citing works
Candidiasis invasoras en recién nacidos: diagnóstico, tratamiento y prevención
Giannina Izquierdo, C., & Santolaya, M. E. (2014) · Revista chilena de infectología · doi:10.4067/s0716-10182014000100011 · Cited by 20 · see citing works
Recommendations for the management of candidemia in neonates in Latin America
Santolaya, M. E., Matute, T. A., Telles, F. D. Q., Colombo, A. L., Zurita, J., Tiraboschi, I. N., Cortés, J. A., Thompson-Moya, L., Guzmán-Blanco, M., Sifuentes‐Osornio, J., et al. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.05.012 · Cited by 18 · see citing works
Neonatal liver abscesses associated with candidemia: three cases and review of literature
Cascio, A., Pantaleo, D., Corona, G., Barberi, G., Delfino, D., Romeo, O., Iaria, C., & Barberi, I. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.837878 · Cited by 17 · see citing works
The Paediatric European Confederation of Medical Mycology ( ECMM ) Quality (Paed‐ EQUAL ) Candida Score for the Management of Candidaemia in Children and Neonates
Bal, A. M., Pana, Z. D., Carlesse, F. A. D. M. C., Marek, A., Seidel, D., Mehler, K., Butzer, S., Sprute, R., Stemler, J., Ludwig-Bettin, D., et al. (2025) · Mycoses · doi:10.1111/myc.70041 · Cited by 15 · see citing works
Guías de práctica clínica para el manejo de la candidiasis: actualización del 2009, de la Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D. R., Benjamin, D. K., Calandra, T., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B. J., Ostrosky-Zeichner, L. L., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/598961 · Cited by 15 · see citing works
A protocol for quality improvement programme to reduce central line-associated bloodstream infections in NICU of low and middle income country
Hussain, A. S., Ali, S. R., Ariff, S., Arbab, S., Demas, S., Zeb, J., & Rizvi, A. (2017) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2017-000008 · Cited by 15 · see citing works
Successful resolution of cardiac mycetomas by combined liposomal Amphotericin B with Fluconazole treatment in premature neonates
Karatza, A., Dimitriou, G., Marangos, M. N., Christofidou, M., Pavlou, V., Giannakopoulos, I. G., Darzentas, A., & Mantagos, S. P. (2008) · European Journal of Pediatrics · doi:10.1007/s00431-007-0634-5 · Cited by 15 · see citing works
Fungal Endocarditis in Neonates
Pana, Z. D., Dotis, J., Iosifidis, Ε., & Roilides, E. (2015) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000735 · Cited by 15 · see citing works
More serious infectious morbidity and mortality associated with simultaneous candidemia and coagulase-negative staphylococcal bacteremia in neonates and in vitro adherence studies between Candida albicans and Staphylococcus epidermidis
Kaufman, D. A., Brown, A. T., Eisenhuth, K. K., Yue, J., Grossman, L. B., & Hazen, K. C. (2014) · Early Human Development · doi:10.1016/s0378-3782(14)70021-0 · Cited by 13 · see citing works
Recent Challenges in Diagnosis and Treatment of Invasive Candidiasis in Neonates
Baltogianni, M. S., Giapros, V. I., & Dermitzaki, N. (2024) · Children · doi:10.3390/children11101207 · Cited by 12 · see citing works
Recomendaciones para el manejo de la candidemia en neonatos en América Latina
Santolaya, M. E., Matute, T. A., Telles, F. D. Q., Colombo, A. L., Zurita, J., Tiraboschi, I. N., Cortés, J. A., Thompson-Moya, L., Guzmán-Blanco, M., Sifuentes‐Osornio, J., et al. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.06.002 · Cited by 12 · see citing works
JSMM Clinical Practice Guidelines for Diagnosis and Treatment of Invasive Candidiasis
(2013) · Medical Mycology Journal · doi:10.3314/mmj.54.147 · Cited by 12 · see citing works
Systemic Candidiasis: Candidemia and Deep-Organ Infections
Clancy, C. J., & Nguyen, M. H. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch27 · Cited by 12 · see citing works
Candidoses et levuroses diverses
Develoux, M., & Bretagne, S. (2005) · EMC-Maladies infectieuses/Encyclopédie médico-chirurgicale. Maladies infectieuses · doi:10.1016/s1166-8598(05)26088-x · Cited by 11 · see citing works
Epidemiology and associated risk factors for candidemia in a Canadian tertiary paediatric hospital: An 11-year review
Liu, S. H., Mitchell, H., & Al‐Rawahi, G. N. (2023) · Journal of the Association of Medical Microbiology and Infectious Disease Canada · doi:10.3138/jammi-2022-0021 · Cited by 10 · see citing works
O Recém-nascido de Alto Risco: teoria e prática do cuidar
Moreira, M. E. L., Lopes, J. M. D. A., & de Carvalho, M. (2004) · Editora FIOCRUZ eBooks · doi:10.7476/9788575412374 · Cited by 12 · see citing works
The Frequency of Ocular Abnormalities in Inpatient Pediatric Ophthalmology Consultations
Hasan, S. J., Yen, K. G., Parghi, C. R., Castanes, M. S., & Edmond, J. C. (2008) · Journal of Pediatric Ophthalmology & Strabismus · doi:10.3928/01913913-20080301-11 · Cited by 10 · see citing works
Correct choices for correct treatments: key issues in the management of Candida infections in preterm neonates
Manzoni, P., Stronati, M., Jacqz-Aigrain, É., Maragliano, R., Ruffinazzi, G., Rizzollo, S., Castagnola, E., & Farina, D. (2012) · Early Human Development · doi:10.1016/s0378-3782(12)70026-9 · Cited by 9 · see citing works
Candidoses invasives en réanimation néonatale
Brissaud, O., Tandonnet, O., & Guichoux, J. (2011) · Archives de Pédiatrie · doi:10.1016/s0929-693x(11)70937-x · Cited by 9 · see citing works
Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
Taliaka, P. K., Tsantes, A. G., Konstantinidi, A., Houhoula, D. P., Tsante, K. A., Vaiopoulos, G., Piovani, D., Nikolopoulos, G. K., Bonovas, S., Iacovidou, N. M., et al. (2023) · Life · doi:10.3390/life13010167 · Cited by 8 · see citing works
Successful medical treatment of Candida endocarditis with liposomal amphotericin B without surgical intervention
Stripeli, F., Tsolia, M. N., Trapali, C., Papaevangelou, V., Vlachos, E., Pasparakis, D., & Constantopoulos, A. (2007) · European Journal of Pediatrics · doi:10.1007/s00431-007-0498-8 · Cited by 8 · see citing works
An Update on the Epidemiology of Candidemia in Children
Dutta, A., Zaoutis, T. E., & Palazzi, D. L. (2012) · Current Fungal Infection Reports · doi:10.1007/s12281-012-0113-y · Cited by 8 · see citing works
Infections fongiques invasives du grand prématuré
Hot, A., Mittaine, B., & Dupont, B. (2006) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2006.09.001 · Cited by 7 · see citing works
Trends in Infantile Endogenous Endophthalmitis Hospitalizations in the United States
Papudesu, C., Mir, T. A., Fang, W., Thompson, J. M., & Hinkle, D. M. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.04.025 · Cited by 6 · see citing works
Surgical Treatment of Giant Candida albicans Vegetation of Tricuspid Valve Endocarditis in a Preterm Baby
Öztürk, E., Tanıdır, İ. C., Güzeltaş, A., & Haydın, S. (2014) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2014.06.009 · Cited by 6 · see citing works
Retinal vasculitis as an early indicator of systemic candidal abscesses in a premature infant
Vinekar, A. S., Avadhani, K., Maralusiddappa, P., Prabhu, V. M. D., Mahendradas, P., & Indumathi, V. A. (2011) · Journal of American Association for Pediatric Ophthalmology and Strabismus · doi:10.1016/j.jaapos.2010.11.005 · Cited by 6 · see citing works
The utility of abdominal ultrasonography in the diagnosis of fungal infections in children: a narrative review
Sungkana, H., Edwards, C. R., & Reddan, T. (2020) · Journal of Medical Radiation Sciences · doi:10.1002/jmrs.431 · Cited by 6 · see citing works
Low Yield of Ancillary Diagnostic Studies in Neonates Infected with Candida
Colby, C. E., Drohan, L., Benitz, W. E., & Hintz, S. R. (2004) · Journal of Perinatology · doi:10.1038/sj.jp.7211076 · Cited by 5 · see citing works
Diagnosis, Risk Factors, Outcomes, and Evaluation of Invasive Candida Infections
Kaufman, D. A., Liken, H. B., & Odackal, N. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-54391-0.00007-2 · Cited by 5 · see citing works
Survey of neonatal candidiasis in Greece
Dotis, J., Evdoridou, J., Kremenopoulos, G., & Roilides, E. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-005-0022-x · Cited by 5 · see citing works
Congenital Sepsis with Candida albicans—A Rare Event in the Neonatal Period: Report of Two Cases and Literature Review
Teacoe, D. A., Cormoș, R. C., Toma, D. A., Ștef, L., Cucerea, M., Muțiu, I., Chicea, R., Popescu, D., Chicea, E. D., Boicean, A., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12091869 · Cited by 4 · see citing works
Diagnosis and management of Candida endophthalmitis and chorioretinitis
Permpalung, N., Sedik, S., Pappas, P. G., Hoenigl, M., & Ostrosky‐Zeichner, L. (2025) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2025.05.028 · Cited by 4 · see citing works
Giant Mycotic Right Atrial Thrombus Due to Candida dubliniensis Septicemia in a Premature Infant
Grizelj, R., Vuković, J., Šarić, D., & Luetić, T. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181e0ccc0 · Cited by 4 · see citing works
Candidiasis
Bendel, C. M. (2006) · Elsevier eBooks · doi:10.1016/b0-72-160537-0/50035-9 · Cited by 4 · see citing works
Cerebral Candidiasis in a 4-Year-Old Boy After Intestinal Surgery
Zhang, S. (2014) · Journal of Child Neurology · doi:10.1177/0883073814531824 · Cited by 4 · see citing works
Fungal Prophylaxis in the Neonatal Intensive Care Unit
Healy, C. M. (2008) · NeoReviews · doi:10.1542/neo.9-12-e562 · Cited by 3 · see citing works
Candidiasis
Bendel, C. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6400-8.00033-x · Cited by 3 · see citing works
Recombinant tissue plasminogen activator treatment for intracardiac vegetation in a very low birth weight infant
Özdemir, A. A. (2017) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2017.eng.e307 · Cited by 3 · see citing works

Risk factors and outcomes of patients with ocular involvement of candidemia
Son, H., Kim, M. J., Lee, S., Choi, S., Jung, K. H., Jung, J., Chong, Y. P., Kim, S., Choi, S., Kim, Y. S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222356 · Cited by 40 · see citing works
Ophthalmologic Examination and Echocardiography Should be the Essential Components of Candidemia Bundle
Erol, Ç., Sarı, N., Yalçın, T. Y., Yesilkaya, A., Asena, L., Güngör, S. G., & Azap, Ö. K. (2023) · Infectious Diseases and Clinical Microbiology · doi:10.36519/idcm.2023.203 · Cited by 3 · see citing works
1441Risk factors and Treatment outcomes of Candida Ocular Infection in Candidemia Patients: Analysis of 845 cases over a 15-year period
Ryu, S. Y. (2014) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofu052.987
Neonatal Candidemia and End-Organ Damage: A Critical Appraisal of the Literature Using Meta-analytic Techniques
Benjamin, D. K., Poole, C., Steinbach, W. J., Rowen, J. L., & Walsh, T. J. (2003) · PEDIATRICS · doi:10.1542/peds.112.3.634 · Cited by 232 · see citing works
1702. Disseminated Candidiasis after Candidemia: Epidemiology, Diagnostic Evaluation, and Risk Factors
Whitehurst, D. A., Murphy, C. R., Teoh, Z., Brammer, C. N., Perkins, K., Paulsen, G. C., Danziger‐Isakov, L. A., Miller‐Handley, H., & Otto, W. R. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad500.1535 · Cited by 1 · see citing works

Authors: Noyola, D. E., Fernandez, M., Moylett, E. H., & Baker, C. J.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Baker, C. J.
ORCID: Noyola, D. E.
Fernandez, M.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2001-04-01
Volume: 32
Issue: 7
Pages: 1018-1023
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/319601
OpenAlex: W2008519120
Cited by: 137
References: 29
Citations by year: 2025: 4 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 9 · 2016: 1 · 2015: 3 · 2014: 7 · 2013: 12 · 2012: 9
FWCI: 4.54
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords: neonatal candidemia, systemic candidiasis, retinal abnormalities, ocular complications, visceral involvement, cardiac involvement, endocarditis, renal involvement, amphotericin B, central venous catheters, Candida species
MeSH terms: Candida, Candidiasis, Eye Diseases, Female, Heart Diseases, Humans, Infant, Newborn, Kidney Diseases, Liver Diseases, Male, Retrospective Studies, Fungemia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ophthalmologic, Visceral, and Cardiac Involvement in Neonates with Candidemia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks