Risk Factors and Predictors of Outcome in Patients with Cancer and Breakthrough Candidemia
Open accessAbstract
Hematogenous candidiasis adds substantially to the morbidity and mortality rates of patients with cancer. Little is known about the risk factors and outcome in patients with breakthrough (BT) candidemia while on systemic antifungal therapy. All 479 episodes of candidemia in 474 consecutive patients with candidemia that was diagnosed at M. D. Anderson Cancer Center from 1988 through 1992 were studied retrospectively. A total of 49 patients had BT candidemia, defined as candidemia that developed after at least 5 days of systemic antifungal therapy. Risk factors for BT candidemia and predictors of mortality were investigated. Multivariate analysis revealed that intensive care unit stay, neutropenia, use of corticosteroids, and duration of neutropenia as significant risk factors for BT candidemia. Seventy-six percent of patients with BT candidemia died, compared with 50% of patients with non-BT infection. In multivariate analysis, intensive care unit stay, being and remaining neutropenic, APACHE III score, and disseminated disease were independent prognostic factors. In conclusion, identification of risk factors and predictors of a poor outcome in patients with cancer with BT candidemia may have important implications in early diagnosis and appropriate therapy of these patients.
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Neutropenia is a major risk factor for mortality after invasive candidiasis in both mice and humans.
“neutropenia is a major risk factor for mortality after invasive candidiasis in both mice and humans [9], [32].”
From Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis (2012) · cites this paper as [32]
Breakthrough or persistence of candidemia during antifungal therapy suggests an infected intravascular device, significant immunosuppression, or microbiological resistance.
“Breakthrough (or persistence of) candidemia in the face of ongoing antifungal therapy suggests the possibility of an infected intravascular device [135], significant immunosuppression [136], or microbiological resistance.”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [136]
Cites
The APACHE III Prognostic System
Knaus, W. A., Wagner, D. P., Draper, E. A., Zimmerman, J. E., Bergner, M., BASTOS, P. G., Sirio, C., Murphy, D. J., Lotring, T., Damiano, A., et al. (1991) · CHEST Journal · doi:10.1378/chest.100.6.1619 · Cited by 3,524 · see citing works
The APACHE III Prognostic System
Teres, D., & Lemeshow, S. A. (1992) · CHEST Journal · doi:10.1378/chest.102.6.1919b · Cited by 2,880 · see citing works
A simplified acute physiology score for ICU patients
Gall, J. L., Loirat, P., Alpérovitch, A., GLASER, P., Granthil, C., Mathieu, D., MERCIER, P., THOMAS, R., & Villers, D. (1984) · Critical Care Medicine · doi:10.1097/00003246-198411000-00012 · Cited by 1,247 · see citing works
Hospital-Acquired Candidemia: The Attributable Mortality and Excess Length of Stay
Wey, S. B. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380120094019 · Cited by 831 · see citing works
The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance
Hong Nguyen, M., Peacock, J. E., Morris, A. J., Tanner, D. C., Nguyen, M. L., Snydman, D. R., Wagener, M. M., Rinaldi, M. G., & Yu, V. L. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(95)00010-0 · Cited by 758 · see citing works
The Epidemiology of Hematogenous Candidiasis Caused by Different Candida Species
Abi‐Said, D., Anaissie, E., Uzun, O., Raad, I., Pinzcowski, H., & Vartivarian, S. (1997) · Clinical Infectious Diseases · doi:10.1086/513663 · Cited by 755 · see citing works
Self-citationViscoli, C., Girmenia, C., Marinus, A., Collette, L., Martino, P., Vandercam, B., Doyen, C., Lebeau, B., Spence, D., Krcmery, V., et al. (1999) · Clinical Infectious Diseases · doi:10.1086/514731 · Cited by 601 · see citing works
Predominant pathogens in hospital infections
Jarvis, W. R., & Martone, W. J. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/29.suppl_a.19 · Cited by 581 · see citing works
Predictors of Adverse Outcome in Cancer Patients with Candidemia
Anaissie, E. J., Rex, J. H., Uzun, Ö., & Vartivarian, S. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00030-8 · Cited by 295 · see citing works
Self-citationAmphotericin B-resistant yeast infection in severely immunocompromised patients
Powderly, W. G., Kobayashi, G. S., Herzig, G. P., & Medoff, G. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90059-9 · Cited by 232 · see citing works
Breakthrough invasive fungal infections in neutropenic patients after prophylaxis with itraconazole
Glasmacher, A. G., Hahn, C., Leutner, C., Molitor, E., Wardelmann, E., Losem, C. J., Sauerbruch, T., Marklein, G., & Schmidt‐Wolf, I. G. H. (1999) · Mycoses · doi:10.1046/j.1439-0507.1999.00505.x · Cited by 147 · see citing works
Krcmery, V., Oravcova, E., Spanik, S., Mrazova-Studena, M., Trupl, J., Kunova, A., Stopkova, K., Kukuckova, E., Krupova, I., Demitrovicova, A., et al. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/41.3.373 · Cited by 102 · see citing works
Estey, E. H., Smith, T. L., Keating, M. J., McCREDIE, K. B., Gehan, E. A., & Freireich, E. J. (1989) · PubMed · Cited by 94 · see citing works
Uptake of minocycline by Escherichia coli
Chopra, I., & Hacker, K. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/29.1.19 · Cited by 89 · see citing works
Blumberg, E. A., & Reboli, A. C. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.3.462 · Cited by 45 · see citing works
Editorial Response: Catheters and Candidemia
Rex, J. H. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.3.467 · Cited by 39 · see citing works
Self-citationGirmenia, C., Martino, P., & Cassone, A. (1996) · Blood · doi:10.1182/blood.v87.2.838.bloodjournal872838 · Cited by 26 · see citing works
Hazards of inadequate fluconazole dosage to treat deep-seated or systemic Candida albicans infection
Flanagan, P., & Barnes, R. A. (1997) · Journal of Infection · doi:10.1016/s0163-4453(97)93270-9 · Cited by 25 · see citing works
Breakthrough Candidemia in Neutropenic Patients
Nucci, M., Colombo, A. L., Spector, N., Velasco, E., Martins, C. A., & Pulcheri, W. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.2.275 · Cited by 21 · see citing works
López‐Jiménez, J., Duarte, R. F., Cabezudo, M.-E., Jj, V.-M., Sousa, A., & Odriozola, J. (1997) · Blood · doi:10.1182/blood.v89.9.3491 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 21 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.26 · Cited by 1,636 · see citing works
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Self-citationAndes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793 · see citing works
Self-citationNosocomial fungal infections: epidemiology, diagnosis, and treatment
Perlroth, J., Choi, B., & Spellberg, B. (2007) · Medical Mycology · doi:10.1080/13693780701218689 · Cited by 738 · see citing works
Immune defence against Candida fungal infections
Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Kullberg, B.-J., & van de Veerdonk, F. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3897 · Cited by 642 · see citing works
Interactions of fungal pathogens with phagocytes
Erwig, L. P., & Gow, N. A. R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.21 · Cited by 626 · see citing works
Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients
Neofytos, D., Fishman, J. A., Horn, D., Anaissie, E. J., Chang, C., Olyaei, A. J., Pfaller, M. A., Steinbach, W. J., Webster, K. M., & Marr, K. A. (2010) · Transplant Infectious Disease · doi:10.1111/j.1399-3062.2010.00492.x · Cited by 455 · see citing works
Self-citationAn update on antifungal targets and mechanisms of resistance in<i>Candida</i><i>albicans</i>
Akins, R. A. (2005) · Medical Mycology · doi:10.1080/13693780500138971 · Cited by 291 · see citing works
Improved survival of critically ill cancer patients with septic shock
Larché, J., Azoulay, É., Fieux, F., Mesnard, L., Moreau, D., Thiéry, G., Darmon, M., Gall, J. L., & Schlemmer, B. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1957-y · Cited by 282 · see citing works
Viudes, A., Pemán, J., Cantón, R., Úbeda, P., Lopez-Ribot, J. L., & Gobernado, M. (2002) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-002-0822-1 · Cited by 248 · see citing works
Cornely, O. A., Hoenigl, M., Lass‐Flörl, C., Chen, S. C. ‐., Kontoyiannis, D. P., Morrissey, C. O., & Thompson, G. R. (2019) · Mycoses · doi:10.1111/myc.12960 · Cited by 224 · see citing works
Antimicrobial therapy for patients with severe sepsis and septic shock: An evidence-based review
Bochud, P., Bonten, M. J. M., Marchetti, O., & Calandra, T. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000143118.41100.14 · Cited by 195 · see citing works
Invasive candidiasis: current clinical challenges and unmet needs in adult populations
Soriano, À., Honoré, P. M., Puerta‐Alcalde, P., García‐Vidal, C., Pagotto, A., Gonçalves, D. C., & Verweij, P. E. (2023) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkad139 · Cited by 200 · see citing works
Breakthrough invasive fungal infections: Who is at risk?
Jenks, J. D., Cornely, O. A., Chen, S. C. ‐., Thompson, G. R., & Hoenigl, M. (2020) · Mycoses · doi:10.1111/myc.13148 · Cited by 191 · see citing works
Andes, D. R., Safdar, N., Baddley, J. W., Alexander, B., Brumble, L., Freifeld, A., Hadley, S., Herwaldt, L., Kauffman, C., Lyon, G. M., et al. (2016) · Transplant Infectious Disease · doi:10.1111/tid.12613 · Cited by 182 · see citing works
Management of central venous catheters in patients with cancer and candidemia
Raad, I., Hanna, H., Boktour, M., Girgawy, E., Danawi, H., Mardani, M., Kontoyiannis, D., Darouiche, R., Hachem, R., & Bodey, G. P. (2004) · Clinical Infectious Diseases · doi:10.1086/382874 · Cited by 159 · see citing works
Immunity to Commensal Fungi: Detente and Disease
Wheeler, M. L., Limon, J. J., & Underhill, D. M. (2017) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100342 · Cited by 123 · see citing works
Lionakis, M. S., Fischer, B. G., Lim, J. K., Swamydas, M., Wan, W., Richard Lee, C.-C., Cohen, J. I., Scheinberg, P., Gao, J.-L., & Murphy, P. M. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002865 · Cited by 118 · see citing works
“In agreement, neutropenia is a major risk factor for mortality after invasive candidiasis in both mice and humans [9,32].”
BackgroundNew insights into innate immune control of systemic candidiasis
Lionakis, M. S. (2014) · Medical Mycology · doi:10.1093/mmy/myu029 · Cited by 108 · see citing works
Host response toCandida albicansbloodstream infection and sepsis
Duggan, S., Leonhardt, I., Hünniger, K., & Kurzai, O. (2015) · Virulence · doi:10.4161/21505594.2014.988096 · Cited by 97 · see citing works
Dimopoulos, G., Karabinis, A., Samonis, G., & Falagas, M. E. (2007) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0316-2 · Cited by 97 · see citing works
Systemic mycoses in the immunocompromised host: an update in antifungal therapy
Kontoyiannis, D. P., Mantadakis, E., & Samonis, G. (2003) · Journal of Hospital Infection · doi:10.1053/jhin.2002.1278 · Cited by 96 · see citing works
Safdar, A., van Rhee, F., Henslee-Downey, J., Singhal, S., & Mehta, J. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703252 · Cited by 93 · see citing works
Risk Factors for Breakthrough Candidemia
Nucci, M., & Colombo, A. L. (2002) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-002-0697-1 · Cited by 92 · see citing works
Chen, S. C., Sorrell, T. C., Chang, C. C., Paige, E. K., Bryant, P. A., & Slavin, M. A. (2014) · Internal Medicine Journal · doi:10.1111/imj.12597 · Cited by 78 · see citing works
Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity
Li, D., Jawale, C. V., Zhou, C., Li, L., Trevejo-Nuñez, G., Rahman, S. A., Mullett, S. J., Das, J., Wendell, S. G., Delgoffe, G. M., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.02.017 · Cited by 68 · see citing works
Riera, F. O., Caeiro, J. P., Angiolini, S. C., Vigezzi, C., Rodriguez, E., Icely, P. A., & Sotomayor, C. E. (2022) · Antibiotics · doi:10.3390/antibiotics11070877 · Cited by 65 · see citing works
Recommendations for the treatment of established fungal infections
Thursky, K., Playford, E. G., Seymour, J. F., Sorrell, T. C., Ellis, D. H., Guy, S., Gilroy, N. M., Chu, J., & Shaw, D. (2008) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2008.01725.x · Cited by 66 · see citing works
Park, B. J., Park, J., Taguchi, H., Fukushima, K., Hyon, S.-H., & Takatori, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.06.037 · Cited by 62 · see citing works
EndogenousCandidaendophthalmitis
Sallam, A. B., Lynn, W. A., McCluskey, P., & Lightman, S. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.4.675 · Cited by 60 · see citing works
Safdar, A., Perlin, D. S., & Armstrong, D. (2002) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(02)00423-6 · Cited by 60 · see citing works
Aquino, V. R., Lunardi, L. W., Goldani, L. Z., & Barth, A. L. (2005) · The Brazilian Journal of Infectious Diseases · doi:10.1590/s1413-86702005000500009 · Cited by 59 · see citing works
Kontoyiannis, D. P., Reddy, B. T., Hanna, H. A., Bodey, G. P., Tarrand, J. T., & RAAD, I. I. (2002) · Infection Control and Hospital Epidemiology · doi:10.1086/502104 · Cited by 55 · see citing works
Risk factors and outcome for nosocomial breakthrough candidaemia
Pasqualotto, A. C., Nedel, W. L., Machado, T. S., & Severo, L. C. (2006) · Journal of Infection · doi:10.1016/j.jinf.2005.04.020 · Cited by 54 · see citing works
Lynn, W. A., & Lightman, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17228-0 · Cited by 52 · see citing works
Pitarch, A., Nombela, C., & Gil, C. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004010 · Cited by 51 · see citing works
Recent Advances in Antifungal Prevention and Treatment
Groll, A. H., & Tragiannidis, A. (2009) · Seminars in Hematology · doi:10.1053/j.seminhematol.2009.03.003 · Cited by 48 · see citing works
Breakthrough candidaemia in the era of broad-spectrum antifungal therapies
Cuervo, G., Garcia-Vidal, C., Nucci, M., Puchades, F., Fernández-Ruiz, M., Obed, M., Manzur, A., Gudiol, C., Pemán, J., Aguado, J. M., et al. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.09.029 · Cited by 49 · see citing works
Epidemiology of candidemia in patients with hematologic malignancies and solid tumours in Brazil
Bergamasco, M. D., Garnica, M. M., Colombo, A. L., & Nucci, M. (2012) · Mycoses · doi:10.1111/myc.12013 · Cited by 47 · see citing works
Safdar, A., Chaturvedi, V. P., Koll, B. S., Larone, D. H., Perlin, D. S., & Armstrong, D. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.10.3268-3272.2002 · Cited by 46 · see citing works
Ortega, M., Almela, M., Soriano, À., Marco, F., Martínez, J. A., Muñoz, A., Peñarroja, G., & Mensa, J. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-008-0531-5 · Cited by 43 · see citing works
Ellis, M. E., Hedström, U., Jumaa, P., & Bener, A. (2003) · Medical Mycology · doi:10.1080/13693780310001645337 · Cited by 42 · see citing works
Impaired gut function as risk factor for invasive candidiasis in neutropenic patients
Blijlevens, N. M. A., Donnelly, J. P., & Pauw, B. E. D. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03394.x · Cited by 41 · see citing works
Friendly fungi: symbiosis with commensal Candida albicans
Shao, T., Haslam, D. B., Bennett, R. J., & Way, S. S. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.07.003 · Cited by 40 · see citing works
Hope, W. W., Drusano, G. L., Moore, C. B., Sharp, J., Louie, A., Walsh, T. J., Denning, D. W., & Warn, P. A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00601-06 · Cited by 40 · see citing works
Alkharashi, N., AlJohani, S. M., Layqah, L. A., Masuadi, E., Baharoon, W., Al-Jahdali, H. H., & Baharoon, S. A. (2019) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2019/2015692 · Cited by 40 · see citing works
Nur, S., Sparber, F., Lemberg, C., Guiducci, E., Schweizer, T. A., Zwicky, P., Becher, B., & LeibundGut‐Landmann, S. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008115 · Cited by 38 · see citing works
Bloodstream infections in haematology: Risks and new challenges for prevention
Worth, L. J., & Slavin, M. A. (2008) · Blood Reviews · doi:10.1016/j.blre.2008.10.003 · Cited by 38 · see citing works
The predictors of outcome in immunocompetent patients with hematogenous candidasis
Safdar, A., Bannister, T., & Safdar, Z. (2004) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2003.05.003 · Cited by 38 · see citing works
Stevens, D. A., Brummer, E., & Clemons, K. V. (2006) · The Journal of Infectious Diseases · doi:10.1086/505357 · Cited by 38 · see citing works
Safdar, A., & Armstrong, D. (2002) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703732 · Cited by 37 · see citing works
Petraitienė, R., Petraitis, V., Kelaher, A. M., Sarafandi, A. A., Mickiene, D., Groll, A. H., Sein, T., Bacher, J., & Walsh, T. J. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.2084-2092.2005 · Cited by 36 · see citing works
Bow, E. J. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06906.x · Cited by 36 · see citing works
Chen, X.-C., Xu, J., & Wu, D.-P. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1523 · Cited by 32 · see citing works
Bertagnolio, S., Donati, K. D. G., Tacconelli, E., Scoppettuolo, G., Posteraro, B., Fadda, G., Cauda, R., & Tumbarello, M. (2004) · Journal of Chemotherapy · doi:10.1179/joc.2004.16.2.172 · Cited by 32 · see citing works
Giacobbe, D. R., Esteves, P., Bruzzi, P., Mikulska, M., Furfaro, E., Mesini, A., Tatarelli, P., Grignolo, S., Viscoli, C., Colombo, A. L., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.06.002 · Cited by 30 · see citing works
Cutaneous expression of systemic candidiasis
Pedraz, J., Delgado‐Jiménez, Y., Perez‐Gala, S., Nam‐Cha, S. H., Fernández‐Herrera, J., & García‐Diez, A. (2008) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2007.02524.x · Cited by 30 · see citing works
Kimura, M., Araoka, H., Yamamoto, H., Asano‐Mori, Y., Nakamura, S., Yamagoe, S., Ohno, H., Miyazaki, Y., Abe, M., Yuasa, M., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01791-16 · Cited by 30 · see citing works
Novel insights into host-fungal pathogen interactions derived from live-cell imaging
Bain, J. M., Gow, N. A. R., & Erwig, L. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0463-3 · Cited by 28 · see citing works
Breda, G. L., Tuon, F. F., Meis, J. F. G. M., Herkert, P. F., Hagen, F., de Oliveira, L. Z., Dias, V. D. C., da Cunha, C. A., & Queiroz‐Telles, F. (2017) · Medical Mycology · doi:10.1093/mmy/myx077 · Cited by 27 · see citing works
Tsai, M.-H., Hsu, J., Chu, S., Chang, P., Lai, M., Wu, I.-H., Huang, H., Chiang, M., Fu, R.-H., & Lu, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01123-6 · Cited by 26 · see citing works
Li, C., Wang, H., Yin, M., Han, H., Yue, J.-F., Zhang, F., Shan, T., Guo, H., & Wu, D. (2015) · Internal Medicine · doi:10.2169/internalmedicine.54.3744 · Cited by 26 · see citing works
Kim, S.-H., Choi, J.-K., Cho, S.-Y., Lee, H.-J., Park, S. H., Choi, S.-M., Lee, D.-G., Choi, J.-H., Yoo, J.-H., & Lee, J.-W. (2018) · Medical Mycology · doi:10.1093/mmy/myx038 · Cited by 24 · see citing works
Hirano, R., Sakamoto, Y., Kitazawa, J., Yamamoto, S., & Kayaba, H. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s156633 · Cited by 24 · see citing works
Vázquez, J. A., & Sobel, J. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6640-7_11 · Cited by 25 · see citing works
Phagocytes as central players in the defence against invasive fungal infection
Hünniger, K., & Kurzai, O. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.021 · Cited by 23 · see citing works
Candidemia in the cancer patient: diagnosis, treatment, and future directions
McCarthy, M. W., & Walsh, T. J. (2018) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2018.1536546 · Cited by 23 · see citing works
Host immune responses in the central nervous system during fungal infections
Reyes, E. Y., & Shinohara, M. L. (2022) · Immunological Reviews · doi:10.1111/imr.13101 · Cited by 22 · see citing works
Gamaletsou, M. N., Daikos, G. L., Walsh, T. J., Perlin, D. S., Jiménez‐Ortigosa, C., Psaroulaki, A., Pagoni, M. N., Argyrοpoulou, A., Nepka, M., Perivolioti, E., et al. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.05.015 · Cited by 21 · see citing works
González-Lara, M. F., Torres‐González, P., Cornejo‐Juárez, P., Velázquez-Acosta, C., Martínez‐Gamboa, A., Rangel‐Cordero, A., Bobadilla-del-Valle, M., Ostrosky‐Zeichner, L., Ponce‐de‐León, A., & Sifuentes‐Osornio, J. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2846-2 · Cited by 21 · see citing works
Antifungal resistance: the clinical front.
Perfect, J. R. (2004) · PubMed · Cited by 21 · see citing works
Emergence of resistant Candida in neutropenic patients
Nucci, M., & Colombo, A. L. (2002) · The Brazilian Journal of Infectious Diseases · doi:10.1590/s1413-86702002000300004 · Cited by 21 · see citing works
Lin, K., Chen, P., Chuang, Y., Wang, J., Sun, H., Sheng, W., Chen, Y., & Chang, S. (2018) · Journal of Infection · doi:10.1016/j.jinf.2018.05.011 · Cited by 20 · see citing works
Orasch, C., Mertz, D., Garbino, J., van Delden, C., Emonet, S., Schrenzel, J., Zimmerli, S., Damonti, L., Mühlethaler, K., Imhof, A., et al. (2018) · Journal of Infection · doi:10.1016/j.jinf.2017.12.018 · Cited by 19 · see citing works
Levorato, A. D., De‐la‐Cruz‐Chacón, I., González‐Esquinca, A. R., da Silva, J. D. F., Ferreira, G., dos Santos, D. C., Garces, H. G., Moris, D. V., Marçon, C., Cavalcante, R. D. S., et al. (2020) · The Journal of venomous animals and toxins including tropical diseases · doi:10.1590/1678-9199-jvatitd-2020-0023 · Cited by 19 · see citing works
Serum (1,3)-beta-D-glucan is an inefficient marker of breakthrough candidemia
Abe, M., Kimura, M., Araoka, H., Taniguchi, S., & Yoneyama, A. (2014) · Medical Mycology · doi:10.1093/mmy/myu066 · Cited by 19 · see citing works
Dignani, M. C., Solomkin, J. S., & Anaissie, E. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00008-6 · Cited by 18 · see citing works
Self-citationLai, M., Hsu, J., Chu, S., Wu, I.-H., Huang, H., Lin, C., Lee, I., Chiang, M., Fu, R.-H., & Tsai, M.-H. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0223 · Cited by 17 · see citing works
Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia
Yu, D., Seger, D. L., Peterson, J. F., Kumar, R. N., & Bates, D. W. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-173 · Cited by 16 · see citing works
ARTERIAL RUPTURE AS THE RESULT OF FUNGAL ARTERITIS AFTER RENAL TRANSPLANTATION
Baccarani, U., Risaliti, A., Adani, G. L., Sainz‐Barriga, M., Bresadola, F., Viale, P., Scudeller, L., Beltrami, C. A., Scott, C., Montanaro, D., et al. (2003) · Transplantation · doi:10.1097/01.tp.0000071951.60122.5f · Cited by 16 · see citing works
Invasive fungal infections in cancer patients
Anaissie, E. J., Grazziutti, M., & Nucci, M. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00020-7 · Cited by 16 · see citing works
Self-citationInfections in Patients with Hematologic Malignancies
Papanicolaou, G. A., & Mehta, J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-644-3_3 · Cited by 15 · see citing works
Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands
Swamydas, M., Break, T. J., & Lionakis, M. S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1858-6 · Cited by 14 · see citing works
Chandrasekar, P. H., Sirohi, B., Seibel, N. L., Hsu, J. W., Azie, N. E., Wu, C., & Ruhnke, M. (2018) · Mycoses · doi:10.1111/myc.12748 · Cited by 13 · see citing works
Candidemia in the Surgical Intensive Care Unit
Krcmery, V., & Babela, R. (2002) · Clinical Infectious Diseases · doi:10.1086/340529 · Cited by 13 · see citing works
Clinical predictors of candidemia in medical non-neutropenic, non-ICU patients. The CaMed score
Ruiz‐Ruigómez, M., Dueñas, C., Hernandez, C., García, D. V., Coronado-Álvarez, N. M., Portillo-Tuñón, V., Cardozo, C., Muñoz‐Medina, L., Cabo-Magadán, R., Luna, J. D. D., et al. (2018) · International Journal of Clinical Practice · doi:10.1111/ijcp.13275 · Cited by 12 · see citing works
Antifungal Targets, Mechanisms of Action, and Resistance in Candida albicans
Akins, R. A., & Sobel, J. D. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-180-2_29 · Cited by 12 · see citing works
The yeast–human coevolution: Fungal transition from passengers, colonizers, and invaders
Nenciarini, S., Renzi, S., Paola, M. D., Meriggi, N., & Cavalieri, D. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1639 · Cited by 11 · see citing works
Ahn, H., Lee, R., Cho, S., & Lee, D. (2022) · Blood Research · doi:10.5045/br.2022.2022036 · Cited by 11 · see citing works
Risk factors and outcome for breakthrough candidaemia in patients with cancer
Chung, J., Lee, S., Choi, S., Woo, J., Ryu, J., Kim, Y. S., & Kim, N. J. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01198.x · Cited by 11 · see citing works
Nishida, R., Eriguchi, Y., Miyake, N., Nagasaki, Y., Yonekawa, A., Mori, Y., Kato, K., Akashi, K., & Shimono, N. (2023) · Medical Mycology · doi:10.1093/mmy/myad056 · Cited by 10 · see citing works
Candida infections among neutropenic patients.
Mohammadi, R., & Foroughifar, E. (2016) · Europe PMC (PubMed Central) · Cited by 10 · see citing works
Goel, G., Chandy, M., Bhattacharyya, A., Banerjee, S., Chatterjee, S., Mullick, S. P., Sinha, S., Sengupta, K., Dhar, K., Bhattacharya, S., et al. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3078-5 · Cited by 10 · see citing works
Trends in Antifungal Susceptibility of Candida Species – One Year Observation
Gołaś, M., Netsvyetayeva, I., Sikora, M., Piskorska, K., Sulik‐Tyszka, B., & Swoboda‐Kopeć, E. (2014) · Polish Journal of Microbiology · doi:10.33073/pjm-2014-028 · Cited by 10 · see citing works
Fujitani, S., Ricardo-Dukelow, M., Kamiya, T., Sullivan, L., & Low, L. L. (2006) · Infection Control and Hospital Epidemiology · doi:10.1086/508831 · Cited by 9 · see citing works
Antifungal Targets, Mechanisms of Action, and Resistance in Candida albicans
Akins, R. A., & Sobel, J. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-46718-4_30 · Cited by 9 · see citing works
Nguyen, N. Z. N., Tran, V. G., Baek, J. Y., Kim, Y., Youn, E. H., Na, S. W., Park, S. J., Seo, S., & Kwon, B. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100495 · Cited by 8 · see citing works
Non-albicans candidemia in cancer patients as an increasing health problem
Ghojoghi, A., Erfaninejad, M., Ahmadpour, E., Nazar, E., Barac, A. M., & Fatahinia, M. (2022) · Asian Pacific Journal of Tropical Medicine · doi:10.4103/1995-7645.356992 · Cited by 8 · see citing works
TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils
Viens, A. L., Timmer, K. D., Alexander, N. J., Barghout, R., Milosevic, J., Hopke, A. R., Atallah, N. J., Scherer, A. K., Sykes, D. B., Irimia, D., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100599 · Cited by 8 · see citing works
(2004) · CRC Press eBooks · doi:10.1201/b14177 · Cited by 8 · see citing works
- Authors
- Uzun, O., Ascioglu, S., Anaissie, E. J., & Rex, J. H.
- Affiliations
- University of Arkansas Medical Center (US)
- ORCID
- Rex, John H.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06-15
- Volume
- 32
- Issue
- 12
- Pages
- 1713-1717
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2109850966
- Cited by
- 138
- References
- 21
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 10 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 7 · 2014: 7 · 2012: 5
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- cancer patients, systemic antifungal therapy, risk factors, mortality risk factors, neutropenia, ICU length of stay, corticosteroids, APACHE III score, systemic candidiasis, prognostic factors
- MeSH terms
- Candidiasis, Female, Humans, Male, Middle Aged, Neoplasms, Predictive Value of Tests, Retrospective Studies, Risk Factors, Fungemia
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