Nitric Oxide Synthase 2Lambaréné(G‐954C), Increased Nitric Oxide Production, and Protection against Malaria

Common West African HLA antigens are associated with protection from severe malaria

Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,554 · see citing works

Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection

ALLISON, A. C. (1954) · BMJ · doi:10.1136/bmj.1.4857.290 · Cited by 1,297 · see citing works

Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

McGuire, W. L., Hill, A. V. S., Allsopp, C. E. M., Greenwood, B. M., & Kwiatkowski, D. P. (1994) · Nature · doi:10.1038/371508a0 · Cited by 1,166 · see citing works

Inducible nitric oxide synthase: what difference does it make?

Nathan, C. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119782 · Cited by 948 · see citing works

Sickle-cell disease

Serjeant, G. R. (1997) · The Lancet · doi:10.1016/s0140-6736(97)07330-3 · Cited by 760 · see citing works

Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population.

Snow, R. W., Craig, M., Deichmann, U., & Marsh, K. (1999) · PubMed Central · Cited by 651 · see citing works

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

Ruwende, C., Khoo, S. C., Snow, R. W., Yates, S. N. R., Kwiatkowski, D. P., Gupta, S., Warn, P. A., Allsopp, C. E. M., Gilbert, S. C., Peschu, N., et al. (1995) · Nature · doi:10.1038/376246a0 · Cited by 592 · see citing works

The Treatment of Malaria

White, N. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609123351107 · Cited by 494 · see citing works

A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria

Knight, J. C., Udalova, I. A., Hill, A. V. S., Greenwood, B. M., Peshu, N. M., Marsh, K., & Kwiatkowski, D. P. (1999) · Nature Genetics · doi:10.1038/9649 · Cited by 480 · see citing works

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

Weinberg, J. B., Granger, D. L., Pisetsky, D. S., Seldin, M. F., Misukonis, M. A., Mason, S. N., Pippen, A. M., Ruiz, P., Wood, E. R., & Gilkeson, G. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.651 · Cited by 435 · see citing works

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.

Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., Arnelle, D. R., Hollis, D. R., McDonald, M., & Granger, D. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.557 · Cited by 431 · see citing works

The Role of T H 1 and T H 2 Cells in a Rodent Malaria Infection

Taylor-Robinson, A. W., PHILLIPS, R. S., Severn, A., Moncada, S., & Liew, F. Y. (1993) · Science · doi:10.1126/science.8100366 · Cited by 346 · see citing works

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

Rockett, K. A., Awburn, M. M., Cowden, W. B., & Clark, I. A. (1991) · Infection and Immunity · doi:10.1128/iai.59.9.3280-3283.1991 · Cited by 306 · see citing works

High incidence of malaria in α-thalassaemic children

Williams, T. N., Maitland, K., Bennett, S., Ganczakowski, M., Peto, T., Newbold, C., Bowden, D. K., Weatherall, D. J., & Clegg, J. B. (1996) · Nature · doi:10.1038/383522a0 · Cited by 238 · see citing works

Malaria’s Eve: Evidence of a recent population bottleneck throughout the world populations of Plasmodium falciparum

Rich, S. M., Licht, M. C., Hudson, R. R., & Ayala, F. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4425 · Cited by 230 · see citing works

The Role of Red Blood Cell Polymorphisms in Resistance and Susceptibility to Malaria

Lell, B., May, J., Schmidt‐Ott, R., Lehman, L. G., Luckner, D., Greve, B., Matousek, P., Schmid, D., Herbich, K., Mockenhaupt, F. P., et al. (1999) · Clinical Infectious Diseases · doi:10.1086/515193 · Cited by 192 · see citing works

Ovalocytosis and cerebral malaria

Genton, B., Al-Yaman, F. M., Mgone, C. S., Alexander, N. D. E., Paniu, M. M., Alpers, M. P., & Mokela, D. (1995) · Nature · doi:10.1038/378564a0 · Cited by 180 · see citing works

Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria

Kun, J. F. J., Mordmüller, B. G., Lell, B., Lehman, L. G., Luckner, D., & Kremsner, P. G. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78273-8 · Cited by 178 · see citing works

L ‐Arginine‐dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation

Nussler, A. K., Drapier, J., Rénia, L., Pied, S., Miltgen, F., Gentilini, M., & Mazier, D. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210134 · Cited by 176 · see citing works

IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism

Mellouk, S., Green, S. J., Nacy, C. A., & Hoffman, S. L. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.11.3971 · Cited by 167 · see citing works

Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambaréné, Gabon

Kun, J. F. J., Schmidt‐Ott, R., Lehman, L. G., Lell, B., Luckner, D., Greve, B., Matousek, P., & Kremsner, P. G. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)90979-8 · Cited by 164 · see citing works

Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S

Agarwal, A., Guindo, A., Cissoko, Y., Taylor, J. G., Coulibaly, D., Kone, A. K., Kayentao, K., DJIMDÉ, A. A., Plowe, C. V., Doumbo, O. K., et al. (2000) · Blood · doi:10.1182/blood.v96.7.2358.h8002358_2358_2363 · Cited by 164 · see citing works

The epidemiology of malaria

Greenwood, B. M. (1997) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034989760518 · Cited by 153 · see citing works

Inducible nitric oxide synthase polymorphism and fatal cerebral malaria

Burgner, D. P., Xu, W., Rockett, K. A., Gravenor, M. B., Charles, I. G., Hill, A. V. S., & Kwiatkowski, D. P. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60531-4 · Cited by 127 · see citing works

High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria

Kremsner, P. G., Winkler, S., Wildling, E., Prada, J., Bienzle, U., Graninger, W., & Nussler, A. K. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90476-9 · Cited by 114 · see citing works

Mannose‐Binding Lectin Plasma Levels and Gene Polymorphisms inPlasmodium falciparumMalaria

Luty, A. J. F., Kun, J. F. J., & Kremsner, P. G. (1998) · The Journal of Infectious Diseases · doi:10.1086/515690 · Cited by 107 · see citing works

Nitric oxide expression in the spleen, but not in the liver, correlates with resistance to blood-stage malaria in mice

Jacobs, P., Radzioch, D., & Stevenson, M. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.11.5306 · Cited by 103 · see citing works

Malaria pigment in leucocytes

Metzger, W. G., Mordmüller, B. G., & Kremsner, P. G. (1995) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(95)90423-9 · Cited by 102 · see citing works

Nitric Oxide Synthase Type 2 Promoter Polymorphisms, Nitric Oxide Production, and Disease Severity in Tanzanian Children with Malaria

Levesque, M. C., Hobbs, M. R., Anstey, N. M., Vaughn, T. N., Chancellor, J. A., Pole, A. R., Perkins, D. J., Misukonis, M. A., Chanock, S. J., Granger, D. L., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/315140 · Cited by 89 · see citing works

Quinine plus clindamycin improves chemotherapy of severe malaria in children

Kremsner, P. G., Radloff, P. D., Metzger, W. G., Wildling, E., Mordmüller, B. G., Philipps, J., Jenne, L., Nkeyi, M., Prada, J., & Bienzle, U. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.7.1603 · Cited by 82 · see citing works

Blood Mononuclear Cell Nitric Oxide Production and Plasma Cytokine Levels in Healthy Gabonese Children with Prior Mild or Severe Malaria

Perkins, D. J., Kremsner, P. G., Schmid, D., Misukonis, M. A., Kelly, M. A., & Weinberg, J. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4977-4981.1999 · Cited by 68 · see citing works

A Comparative Trial of Three Regimens for Treating Uncomplicated Falciparum Malaria in Acre, Brazil

Kremsner, P. G., Zotter, G. M., Feldmeier, H., GRANINGER, W., Rocha, R. M., & Wiedermann, G. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.6.1368 · Cited by 68 · see citing works

Interferon‐γ induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine

Kremsner, P. G., Neifer, S., Chaves, M. F., Rudolph, R., & Bienzle, U. (1992) · European Journal of Immunology · doi:10.1002/eji.1830221118 · Cited by 46 · see citing works

No influence of socioeconomic factors on severe malarial anaemia, hyperparasitaemia or reinfection

Luckner, D., Lell, B., Greve, B., Lehman, L. G., Schmidt‐Ott, R., Matousek, P., Herbich, K., Schmid, D., Mba, R., & Kremsner, P. G. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)90882-3 · Cited by 38 · see citing works

Enchanced production of reactive nitrogen intermediates in human and murine malaria

Prada, J., & Kremsner, P. G. (1995) · Parasitology Today · doi:10.1016/0169-4758(95)80019-0 · Cited by 34 · see citing works

Plasmodium falciparum transmission intensity and infection rates in children in Gabon

Sylla, E. H. D., Lell, B., Kremsner, P. G., & Kun, J. (2001) · Parasitology Research · doi:10.1007/s004360100407 · Cited by 33 · see citing works

Pyrimethamine/sulfadoxine for treating uncomplicated Plasmodium falciparum malaria in young children in Gabon

Schmidt‐Ott, R., Luckner, D., Lehman, L. G., Lell, B., Matousek, P., Greve, B., & Kremsner, P. G. (1997) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(97)90033-x · Cited by 19 · see citing works

Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676 · see citing works

How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria

Kwiatkowski, D. P. (2005) · The American Journal of Human Genetics · doi:10.1086/432519 · Cited by 1,106 · see citing works

Nitric oxide and redox mechanisms in the immune response

Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010550 · Cited by 765 · see citing works

Innate immunity to malaria

Stevenson, M. M., & Riley, E. M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1311 · Cited by 652 · see citing works

Regulation of the expression of inducible nitric oxide synthase

Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C., & Kleinert, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.04.007 · Cited by 549 · see citing works

Regulation of the Expression of Inducible Nitric Oxide Synthase

Kleinert, H., Schwarz, P. M., & Förstermann, U. (2003) · Biological Chemistry · doi:10.1515/bc.2003.152 · Cited by 422 · see citing works

Inflammation and oxidative stress in vertebrate host–parasite systems

Sorci, G., & Faivre, B. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0151 · Cited by 350 · see citing works

Malarial hemozoin: From target to tool

Coronado, L. M., Nadovich, C. T., & Spadafora, C. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.02.009 · Cited by 288 · see citing works

Immunopathogenesis of cerebral malaria

Hunt, N. H., Golenser, J., Chan‐Ling, T., Parekh, S. B., Rae, C. D., Potter, S. M., Medana, I. M., Miu, J., & Ball, H. J. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.02.016 · Cited by 249 · see citing works

A functional promoter polymorphism in monocyte chemoattractant protein–1 is associated with increased susceptibility to pulmonary tuberculosis

Flores-Villanueva, P. O., Ruiz-Morales, J. A., Song, C., Flores, L. M., Jo, E., Montaño, M., Barnes, P. F., Selman, M., & Granados, J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050126 · Cited by 241 · see citing works

Regulating immunity to malaria

Riley, E. M., Wahl, S. M., Perkins, D. J., & Schofield, L. (2005) · Parasite Immunology · doi:10.1111/j.1365-3024.2006.00775.x · Cited by 202 · see citing works

Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression

Schwarzer, E., Arese, P., & Skorokhod, O. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/638416 · Cited by 202 · see citing works

A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children

Hobbs, M. R., Udhayakumar, V., Levesque, M. C., Booth, J., Roberts, J. M., Tkachuk, A. N., Pole, A. R., Coon, H. H., Kariuki, S., Nahlen, B. L., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11474-7 · Cited by 188 · see citing works

Malaria and anemia

Ekvall, H. (2003) · Current Opinion in Hematology · doi:10.1097/00062752-200303000-00002 · Cited by 169 · see citing works

Flavohemoglobin Hmp ProtectsSalmonella entericaSerovar Typhimurium from Nitric Oxide-Related Killing by Human Macrophages

Stevanin, T. M., Poole, R. K., Demoncheaux, E. A. G., & Read, R. C. (2002) · Infection and Immunity · doi:10.1128/iai.70.8.4399-4405.2002 · Cited by 169 · see citing works

Mechanisms of genetically-based resistance to malaria

López, C., Saravia, C., Gomez, A., Hoebeke, J., & Patarroyo, M. A. (2010) · Gene · doi:10.1016/j.gene.2010.07.008 · Cited by 164 · see citing works

Genetic polymorphisms linked to susceptibility to malaria

Driss, A., Hibbert, J. M., Wilson, N. O., Iqbal, S. A., Adamkiewicz, T. V., & Stiles, J. K. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-271 · Cited by 152 · see citing works

The Role of Reactive Species on Innate Immunity

Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works

Past, present and future directions in human genetic susceptibility to tuberculosis

Möller, M., de Wit, E., & Hoal, E. G. (2009) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2009.00600.x · Cited by 126 · see citing works

Species differences in macrophage NO production are important

Schneemann, M., & Schoedon, G. (2002) · Nature Immunology · doi:10.1038/ni0202-102a · Cited by 124 · see citing works

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase

Iwakiri, Y. (2015) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2015.21.4.319 · Cited by 119 · see citing works

Elevated Nitric Oxide Production in Children with Malarial Anemia: Hemozoin-Induced Nitric Oxide Synthase Type 2 Transcripts and Nitric Oxide in Blood Mononuclear Cells

KELLER, C. C., Kremsner, P. G., Hittner, J. B., Misukonis, M. A., Weinberg, J. B., & Perkins, D. J. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4868-4873.2004 · Cited by 111 · see citing works

Nitric oxide: therapeutic opportunities

Vallance, P. J. (2003) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2003.00124.x · Cited by 104 · see citing works

Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria

Weinberg, J. B., Lopansri, B. K., Mwaikambo, E. D., & Granger, D. L. (2008) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32830ef5cf · Cited by 97 · see citing works

Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics

Sirugo, G., Hennig, B. J., Adeyemo, A., Matimba, A., Newport, M. J., Ibrahim, M. E., Ryckman, K. K., Tacconelli, A., Mariani‐Costantini, R., Novelli, G., et al. (2008) · Human Genetics · doi:10.1007/s00439-008-0511-y · Cited by 95 · see citing works

Diethylcarbamazine activity against Brugia malayimicrofilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway

McGarry, H. F., Plant, L. D., & Taylor, M. J. (2005) · Filaria Journal · doi:10.1186/1475-2883-4-4 · Cited by 91 · see citing works

Nitric oxide production by human macrophages: there's NO doubt about it

Fang, F. C., & Vázquez‐Torres, A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00017.2002 · Cited by 91 · see citing works

Anti-Adhesive Effect of Nitric Oxide on Plasmodium falciparum Cytoadherence under Flow

Serirom, S., Raharjo, W. H., Chotivanich, K., Loareesuwan, S., Kubes, P., & Ho, M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64299-x · Cited by 88 · see citing works

NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans

Velez, D. R., Hulme, W. F., Myers, J. L., Weinberg, J. B., Levesque, M. C., Stryjewski, M. E., Abbate, E. H., Estevan, R., Patillo, S. G., Gilbert, J. R., et al. (2009) · Human Genetics · doi:10.1007/s00439-009-0713-y · Cited by 81 · see citing works

The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus

Oates, J. C., & Gilkeson, G. S. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.001 · Cited by 77 · see citing works

Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome‐wide association studies

Verra, F., Mangano, V. D., & Modiano, D. (2009) · Parasite Immunology · doi:10.1111/j.1365-3024.2009.01106.x · Cited by 74 · see citing works

Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria

Burgner, D. P., Usen, S., Rockett, K. A., Jallow, M., Ackerman, H. C., Cervino, A., Pinder, M., & Kwiatkowski, D. P. (2003) · Human Genetics · doi:10.1007/s00439-002-0882-4 · Cited by 70 · see citing works

Evidence That Interferon‐γ Plays a Protective Role during Cerebral Malaria

Cabantous, S., Poudiougou, B., Traore, A. M., Keita, M. M., Cissé, M. B., Doumbo, O. K., Dessein, A. J. J., & Marquet, S. (2005) · The Journal of Infectious Diseases · doi:10.1086/432484 · Cited by 70 · see citing works

Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival

Zell, J. A., Ignatenko, N. A., Yerushalmi, H. F., Ziogas, A., Besselsen, D. G., Gerner, E. W., & Anton‐Culver, H. (2006) · International Journal of Cancer · doi:10.1002/ijc.22311 · Cited by 69 · see citing works

Inducible Nitric Oxide Synthase (iNOS) Gene Polymorphism and Disease Prevalence

Qidwai, T., & Jamal, F. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02458.x · Cited by 68 · see citing works

Genetic epidemiology of health disparities in allergy and clinical immunology

Barnes, K. C. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.11.030 · Cited by 68 · see citing works

Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I

Jueliger, S., Bongartz, M., Luty, A. J. F., Kremsner, P. G., & Kun, J. F. J. (2002) · Immunogenetics · doi:10.1007/s00251-002-0516-y · Cited by 66 · see citing works

Genetic Determination and Linkage Mapping of Plasmodium falciparum Malaria Related Traits in Senegal

Sakuntabhai, A., Ndiaye, R., Casadémont, I., Peerapittayamonkol, C., Rogier, C., Tortevoye, P., Tall, A., Paul, R. E. L., Turbpaiboon, C., Phimpraphi, W., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002000 · Cited by 65 · see citing works

Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis

Barcellos, L. F., Begovich, A. B., Reynolds, R., Caillier, S. J., Brassat, D., Schmidt, S., Grams, S. E., Walker, K., Steiner, L. L., Cree, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20092 · Cited by 60 · see citing works

Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis

Oates, J. C., Shaftman, S. R., Self, S., & Gilkeson, G. S. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23153 · Cited by 59 · see citing works

Polymorphisms in Genes Involved in Innate Immunity Predispose Toward Mycetoma Susceptibility

van de Sande, W. W. J., Fahal, A. H., Verbrugh, H. A., & van Belkum, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3065 · Cited by 58 · see citing works

History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon

Ramharter, M., Adégnika, A. A., Agnandji, S. T., Matsiegui, P., Grobusch, M. P., Winkler, S., Graninger, W., Krishna, S., Yazdanbakhsh, M., Mordmüller, B. G., et al. (2007) · Wiener klinische Wochenschrift · doi:10.1007/s00508-007-0857-5 · Cited by 57 · see citing works

Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand

Ohashi, J., Naka, I., Patarapotikul, J., Hananantachai, H., Looareesuwan, S., & Tokunaga, K. (2002) · The Journal of Infectious Diseases · doi:10.1086/341779 · Cited by 57 · see citing works

Metabolic Complications of Severe Malaria

Planche, T., Dzeing‐Ella, A., Ngou-Milama, E., Kombila, M., & Stacpoole, P. W. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-29088-5_5 · Cited by 57 · see citing works

Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population

Möller, M., Nebel, A., Valentonyte, R., van Helden, P. D., Schreiber, S., & Hoal, E. G. (2009) · Tuberculosis · doi:10.1016/j.tube.2008.10.001 · Cited by 56 · see citing works

Stressor-Induced Increase in Microbicidal Activity of Splenic Macrophages Is Dependent upon Peroxynitrite Production

Allen, R. G., Lafuse, W. P., Powell, N. D., Marketon, J. I. W., Stiner, L., Sheridan, J. F., & Bailey, M. T. (2012) · Infection and Immunity · doi:10.1128/iai.00714-12 · Cited by 53 · see citing works

Increased Pulmonary Pressures and Myocardial Wall Stress in Children with Severe Malaria

Janka, J., Koita, O., Traoré, B., Traoré, J. M., Mzayek, F., Sachdev, V., Wang, X., Sanogo, K. M., Sangaré, L., Mendelsohn, L. G., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/655225 · Cited by 50 · see citing works

iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection

Kumar, A., Singh, K. P., Bali, P., Anwar, S., Kaul, A., Singh, O. P., Gupta, B. K., Kumari, N., Alam, M. N., Raziuddin, M., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.12.005 · Cited by 50 · see citing works

Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.

Oates, J. C., Levesque, M. C., Hobbs, M. R., Smith, E. G., Molano, I. D., Page, G. P., Hill, B. S., Weinberg, J. B., Cooper, G. S., & Gilkeson, G. S. (2003) · PubMed · Cited by 45 · see citing works

HOST POLYMORPHISMS AND THE INCIDENCE OF MALARIA IN UGANDAN CHILDREN

Parikh, S., Dorsey, G., & Rosenthal, P. J. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.750 · Cited by 44 · see citing works

Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective

Penha‐Gonçalves, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01771 · Cited by 42 · see citing works

iNOS promoter variants and severe malaria in Ghanaian children

Cramer, J. P., Mockenhaupt, F. P., Ehrhardt, S., Burkhardt, J., Otchwemah, R. N., Dietz, E., Gellert, S., & Bienzle, U. (2004) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2004.01312.x · Cited by 42 · see citing works

Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults

Levesque, M. C., Hauswirth, D. W., Mervin-Blake, S., Fernandez, C. A., Patch, K. B., Alexander, K. M., Allgood, S. D., McNair, P. D., Allen, A. S., & Sundy, J. S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.031 · Cited by 42 · see citing works

Regulation of the Expression of Inducible Nitric Oxide Synthase

Kleinert, H., Art, J., & Pautz, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00007-1 · Cited by 40 · see citing works

Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trial

Hawkes, M., Opoka, R. O., Namasopo, S., Miller, C., Thorpe, K. E., Lavery, J. V., Conroy, A. L., Liles, W. C., John, C. C., & Kain, K. C. (2011) · Trials · doi:10.1186/1745-6215-12-176 · Cited by 39 · see citing works

Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparum malaria

Dietmann, A., Lackner, P., Helbok, R., Spora, K., Issifou, S., Lell, B., Reindl, M., Kremsner, P. G., & Schmutzhard, E. (2008) · Malaria Journal · doi:10.1186/1475-2875-7-253 · Cited by 38 · see citing works

TNFα−308A associated with shorter intervals of Plasmodium falciparum reinfections

Meyer, C. G., May, J., Luty, A. J. F., Lell, B., & Kremsner, P. G. (2002) · Tissue Antigens · doi:10.1034/j.1399-0039.2002.590406.x · Cited by 38 · see citing works

To B or Not to B: Understanding B Cell Responses in the Development of Malaria Infection

Silveira, E. L. V., Dominguez, M. R., & Soares, I. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02961 · Cited by 37 · see citing works

TNF family members and malaria: Old observations, new insights and future directions

Randall, L. M., & Engwerda, C. R. (2010) · Experimental Parasitology · doi:10.1016/j.exppara.2010.04.016 · Cited by 36 · see citing works

Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes

Skorokhod, O. A., Schwarzer, E., Ceretto, M., & Arese, P. (2007) · Malaria Journal · doi:10.1186/1475-2875-6-73 · Cited by 35 · see citing works

Suppression of erythroid development in vitro by Plasmodium vivax

Panichakul, T., Payuhakrit, W., Panburana, P., Wongborisuth, C., Hongeng, S., & Udomsangpetch, R. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-173 · Cited by 33 · see citing works

The multiplicity of Plasmodium falciparum infections is associated with acquired immunity to asexual blood stage antigens

Mayengué, P. I., Luty, A. J. F., Rogier, C., Baragatti, M. C., Kremsner, P. G., & Ntoumi, F. (2008) · Microbes and Infection · doi:10.1016/j.micinf.2008.10.012 · Cited by 32 · see citing works

Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection

Lima‐Junior, J. D. C., Rodrigues‐da‐Silva, R. N., Pereira, V. A., Storer, F. L., Perce-da-Silva, D. D. S., Fabrino, D. L., Santos, F., Banic, D. M., & Oliveira-Ferreira, J. (2012) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762012000800012 · Cited by 31 · see citing works

Age‐dependent effect of plasma nitric oxide on parasite density in Ghanaian children with severe malaria

Cramer, J. P., Nussler, A. K., Ehrhardt, S., Burkhardt, J., Otchwemah, R. N., Zanger, P., Dietz, E., Gellert, S., Bienzle, U., & Mockenhaupt, F. P. (2005) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2005.01438.x · Cited by 30 · see citing works

Genes, nitric oxide and malaria in African children

Clark, I. A. (2003) · Trends in Parasitology · doi:10.1016/s1471-4922(03)00147-8 · Cited by 29 · see citing works

Genetic susceptibility to infectious diseases

Clementi, M., & Gianantonio, E. D. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.08.006 · Cited by 29 · see citing works

Anopheles gambiae immune gene variants associated with natural Plasmodium infection

Luckhart, S., Li, K., Dunton, R. F., Lewis, E. E., Crampton, A. L., Ryan, J. R., & Rosenberg, R. (2003) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(03)00016-1 · Cited by 27 · see citing works

NOS2 Variants Reveal a Dual Genetic Control of Nitric Oxide Levels, Susceptibility to Plasmodium Infection, and Cerebral Malaria

Trovoada, M. J., Martins, M., Mansour, R. B., Sambo, M. D. R., Fernandes, A. B., Gonçalves, L. A., Borja, A., Moya, R., Almeida, P., Costa, J., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01070-13 · Cited by 27 · see citing works

Nitric oxide for the adjunctive treatment of severe malaria: Hypothesis and rationale

Hawkes, M., Opoka, R. O., Namasopo, S., Miller, C., Conroy, A. L., Serghides, L., Kim, H., Thampi, N., Liles, W. C., John, C. C., et al. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.003 · Cited by 26 · see citing works

INDUCIBLE NITRIC OXIDE SYNTHASE (NOS2) PROMOTER CCTTT REPEAT POLYMORPHISM: RELATIONSHIP TO IN VIVO NITRIC OXIDE PRODUCTION/NOS ACTIVITY IN AN ASYMPTOMATIC MALARIA-ENDEMIC POPULATION

Boutlis, C. S., Hobbs, M. R., Marsh, R. L., Misukonis, M. A., Tkachuk, A. N., Lagog, M., Booth, J., Granger, D. L., Bockarie, M. J., Mgone, C. S., et al. (2003) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2003.69.569 · Cited by 26 · see citing works

Gastric cancer is associated with NOS2-954G/C polymorphism and environmental factors in a Brazilian population

Jorge, Y. C., Duarte, M. C., & Silva, A. E. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-64 · Cited by 24 · see citing works

Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study

Apinjoh, T. O., Anchang-Kimbi, J. K., Njua-Yafi, C., Ngwai, A. N., Mugri, R. N., Clark, T. G., Rockett, K. A., Kwiatkowski, D. P., & Achidi, E. A. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-236 · Cited by 23 · see citing works

Inducible nitric oxide synthase promoter polymorphism in human brucellosis

Orozco, G., Sánchez, E., López‐Nevot, M. Á., Caballero, A., Bravo, M. J., Morata, P., Colmenero, J., Alonso, A., & Martin, J. J. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.08.010 · Cited by 23 · see citing works

Host Genetic Factors in Resistance and Susceptibility to Malaria

Kwiatkowski, D. P., & Luoni, G. (2014) · ASM Press eBooks · doi:10.1128/9781555817558.ch24 · Cited by 22 · see citing works

Nitric Oxide Synthase and Superoxide Dismutase Gene Polymorphisms in Behçet Disease

Nakao, K. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.2.246 · Cited by 22 · see citing works

Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes

Hernandez-Valladares, M., Rihet, P., & Iraqi, F. A. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00044.2013 · Cited by 21 · see citing works

IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon

Pereira, V. A., Sánchez‐Arcila, J. C., Têva, A., Perce-da-Silva, D. D. S., Vasconcelos, M. P. A., de Lima, C. A. M., Aprígio, C. J. L., Rodrigues‐da‐Silva, R. N., Santos, D. O., Banic, D. M., et al. (2015) · Malaria Journal · doi:10.1186/s12936-015-0548-z · Cited by 21 · see citing works

Host genetic susceptibility to mycetoma

Ali, R. S., Newport, M. J., Bakhiet, S. M., Ibrahim, M. E., & Fahal, A. H. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008053 · Cited by 21 · see citing works

Relationship of bovine TNF-α gene polymorphisms with the risk of bovine tuberculosis in Holstein cattle

Cheng, Y., Huang, C., & Tsai, H. (2016) · Journal of Veterinary Medical Science · doi:10.1292/jvms.15-0506 · Cited by 21 · see citing works

The role of NOS2A -954G/C and vascular endothelial growth factor +936C/T polymorphisms in type 2 diabetes mellitus and diabetic nonproliferative retinopathy risk management

Porojan, M. D., Catana, A. M., Popp, R. A., Dumitrascu, D. L., & Bala, C. G. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s93172 · Cited by 20 · see citing works

Inducible nitric oxide synthase gene promoter polymorphism is associated with increased gastric mRNA expression of inducible nitric oxide synthase and increased risk of gastric carcinoma

Kaise, M., Miwa, J., Suzuki, N., Mishiro, S., Ohta, Y., Yamasaki, T., & Tajiri, H. (2007) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000252637.11291.1d · Cited by 20 · see citing works

IgG opsonization of merozoites: multiple immune mechanisms for malaria vaccine development

Hill, D. L., Schofield, L., & Wilson, D. W. (2017) · International Journal for Parasitology · doi:10.1016/j.ijpara.2017.05.004 · Cited by 20 · see citing works

Immunogenetics and the design of Plasmodium falciparum vaccines for use in malaria-endemic populations

Plebanski, M., Proudfoot, O., Pouniotis, D. S., Coppel, R. L., Apostolopoulos, V., & Flannery, G. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216163 · Cited by 20 · see citing works

A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations

Wang, Z., Feng, K., Yue, M., Lu, X., Zheng, Q.-H., Zhang, H., Zhai, Y., Li, P., Yu, L., Cai, M., et al. (2012) · Human Genetics · doi:10.1007/s00439-012-1253-4 · Cited by 19 · see citing works

No Association ofIFNG+874T/ASNP andNOS2A-954G/CSNP Variants with Nitric Oxide Radical Serum Levels or Susceptibility to Tuberculosis in a Brazilian Population Subset

Leandro, A. C., Rocha, M. A. D., Souza, A. L., VandeBerg, J. L., Rolla, V. C., & Bonecini-Almeida, M. D. G. (2013) · BioMed Research International · doi:10.1155/2013/901740 · Cited by 18 · see citing works

Prevalence of polymorphisms in glucose-6-phosphate dehydrogenase, sickle haemoglobin and nitric oxide synthase genes and their relationship with incidence of uncomplicated malaria in Iganga, Uganda

Lwanira, C. N., Kironde, F., Kaddumukasa, M., & Swedberg, G. (2017) · Malaria Journal · doi:10.1186/s12936-017-1970-1 · Cited by 18 · see citing works

Inhaled Nitric Oxide and Cerebral Malaria

Bergmark, B. A., Bergmark, R. W., Beaudrap, P. D., Boum, Y., Mwanga‐Amumpaire, J., Carroll, R. W., & Zapol, W. M. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e318266c113 · Cited by 18 · see citing works

Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism

Planche, T., Macallan, D. C., Sobande, T. O., Borrmann, S., Kun, J. F. J., Krishna, S., & Kremsner, P. G. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00390.2010 · Cited by 18 · see citing works

A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

Randall, L. M., Kenangalem, E., Lampah, D. A., Tjitra, E., Mwaikambo, E. D., Handojo, T., Piera, K. A., Zhao, Z., Rivera, F. D. L., Zhou, Y., et al. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-302 · Cited by 18 · see citing works

Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality

Kempaiah, P. M., Anyona, S. B., Raballah, E. O., Davenport, G. C., Were, T., Hittner, J. B., Ong’echa, J. M., & Perkins, D. J. (2012) · Human Genetics · doi:10.1007/s00439-012-1175-1 · Cited by 18 · see citing works

The CCTTT pentanucleotide microsatellite in iNOS promoter influences the clinical outcome in P. falciparum infection

Dhangadamajhi, G., Mohapatra, B. N., Kar, S. K., & Ranjit‬, M. (2009) · Parasitology Research · doi:10.1007/s00436-009-1329-9 · Cited by 18 · see citing works

Hemozoin Inhibition and Control of Clinical Malaria

Ihekwereme, C. P., Esimone, C. O., & Nwanegbo, E. C. (2014) · Advances in Pharmacological Sciences · doi:10.1155/2014/984150 · Cited by 17 · see citing works

Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases

Varela, E. L. P., Gomes, A. R. Q., dos Santos, A. D. S. B., de Carvalho, E., Vale, V. V., & Percário, S. (2022) · Nutrients · doi:10.3390/nu14245303 · Cited by 17 · see citing works

Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide

Sivaloganathan, D. M., & Brynildsen, M. P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00330 · Cited by 16 · see citing works

Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People

Zhang, Y., Li, C., Li, K., Liu, L., Jian, Z., & Gao, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027077 · Cited by 16 · see citing works

Redox sensing and signaling by malaria parasite in vertebrate host

Tripathy, S., & Roy, S. (2015) · Journal of Basic Microbiology · doi:10.1002/jobm.201500031 · Cited by 16 · see citing works

Reactive Oxygen and Reactive Nitrogen Metabolites as Effector Molecules against Infectious Pathogens

Bogdan, C. (2014) · ASM Press eBooks · doi:10.1128/9781555817671.ch19 · Cited by 16 · see citing works

Nitric oxide protects against chloroquine resistant Plasmodium yoelii nigeriensis parasites in vitro

Awasthi, A., Kumar, A., Upadhyay, S. N., Yamada, T., & Matsunaga, Y. (2003) · Experimental Parasitology · doi:10.1016/j.exppara.2003.12.008 · Cited by 15 · see citing works

Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene

Coia, V., Jueliger, S., Mordmüller, B. G., Kreidenweiss, A., Stroh, A., Ortega, C., Vindigni, A., Dengjel, J., Lukyanov, D. V., Destro‐Bisol, G., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.178 · Cited by 15 · see citing works

No evidence for association of the inducible nitric oxide synthase promoter polymorphism with Trypanosoma cruzi infection

Calzada, J. E., López‐Nevot, M. Á., Beraún, Y., & Martin, J. J. (2002) · Tissue Antigens · doi:10.1034/j.1399-0039.2002.590411.x · Cited by 13 · see citing works

Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana

Dzodzomenyo, M., Ghansah, A., Ensaw, N., Dovie, D. B. K., Bimi, L., Quansah, R., Gyan, B. A., Gyakobo, M. K., & Amoani, B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202218 · Cited by 10 · see citing works

Increased nitric oxide production and protection from malaria

Wang, W. Y. S., & Adams, D. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12531-7 · Cited by 1 · see citing works

A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children

Hobbs, M. R., Udhayakumar, V., Levesque, M. C., Booth, J., Roberts, J. M., Tkachuk, A. N., Pole, A. R., Coon, H. H., Kariuki, S., Nahlen, B. L., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11474-7 · Cited by 188 · see citing works

Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria

Kun, J. F. J., Mordmüller, B. G., Lell, B., Lehman, L. G., Luckner, D., & Kremsner, P. G. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78273-8 · Cited by 178 · see citing works

Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism

Planche, T., Macallan, D. C., Sobande, T. O., Borrmann, S., Kun, J. F. J., Krishna, S., & Kremsner, P. G. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00390.2010 · Cited by 18 · see citing works