Association between Chronic Disseminated Candidiasis in Adult Acute Leukemia and Common IL4 Promoter Haplotypes
Abstract
Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P= .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P= .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.
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Polymorphisms in several cytokines are associated with susceptibility to specific fungal diseases: aspergillosis with IL-1, IL-10, IL-15, and IL-23; candidiasis with IL-4; paracoccidioidomycosis with IL-4; and blastomycosis with IL-6.
“polymorphisms in a number of cytokines have also been found to predispose to fungal disease: aspergillosis (IL-1 [30], IL-10 [31,32], IL-15 [32], and IL-23); candidiasis (IL-4) [33,34]; paracoccidioidomycosis (IL-4) [35]; and blastomycosis (IL-6) [36].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [33]
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Race and ethnicity: Risk factors for fungal infections?
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- Authors
- Choi, E. H., Foster, C. B., Taylor, J. G., Erichsen, H. C., Chen, R. A., Walsh, T. J., Anttila, V., Ruutu, T., Palotie, A., & Chanock, S. J.
- Affiliations
- National Institutes of Health (US)
- University of Helsinki (FI)
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-04
- Volume
- 187
- Issue
- 7
- Pages
- 1153-1156
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2103553417
- Cited by
- 52
- References
- 15
- Citations by year
- 2023: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- chronic disseminated candidiasis, acute leukemia, IL-4, genetic susceptibility, haplotypes, candidiasis, host genetic factors
- MeSH terms
- Adolescent, Adult, Aged, Candida, Candidiasis, Chronic Disease, Female, Haplotypes, Humans, Leukemia, Male, Middle Aged, Promoter Regions, Genetic, Interleukin-4, Genetic Predisposition to Disease
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