The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Changes in the Levels of Chemokines and Cytokines in the Placentas of Women with Plasmodium falciparum Malaria
Abstract
Plasmodium falciparum-infected erythrocytes often are sequestered in the placenta and stimulate the accumulation of maternal mononuclear cells. In this study, the role that chemokines and cytokines play in mediating the inflammatory response was investigated. Placental parasites elicited a statistically significant increase in the levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-10, in plasma collected from the intervillous space. Explants of fetal tissue from malaria-positive placentas also secreted significantly enhanced amounts of IFN-gamma. Culture supernatant of maternal intervillous leukocytes obtained from infected placentas contained significantly higher levels of TNF-alpha, IL-10, monocyte chemotactic protein-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and IFN-gamma inducible protein-10 than did cultures of white blood cells obtained from uninfected placentas. Taken together, these results show that both fetal and maternal cells secrete inflammatory and immunoregulatory cytokines in response to P. falciparum and suggest that beta-chemokines produced by maternal cells contribute to the accumulation of macrophages in the intervillous space.
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“In addition, activation of immune cells with upregulation of markers such as CD4 + , CD8 + and CD68 + can be observed [121, 123, 124].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [123]
In the citing paper
“PM is associated with inflammatory immune responses [75–79], with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood [80,81].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [76]
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Metadata
- Authors
- Suguitan, Jr., Leke, R. G. F., Fouda, G., Zhou, A., Thuita, L., Metenou, S., Fogako, J., Megnekou, R., & Taylor, D. W.
- Affiliations
- Université de Yaoundé I (CM)
- Georgetown University (US)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10
- Volume
- 188
- Issue
- 7
- Pages
- 1074-7082
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2096731679
- Cited by
- 161
- References
- 44
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 13
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (U01A1 43888)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- Plasmodium falciparum, malaria in pregnancy, placenta, chemokines, cytokines, interferon-gamma, TNF-α, IL-10, MCP-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1β, CXCL10, fetal tissue, placental inflammation, macrophage accumulation, immune regulation
- MeSH terms
- Adult, Animals, Cameroon, Enzyme-Linked Immunosorbent Assay, Female, Fetus, Hematocrit, Humans, Immunohistochemistry, Leukocyte Count, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Cytokines, Malaria, Falciparum, Parasitemia, Chemokines
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