The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Increased Colonization of Indwelling Medical Devices by Quorum‐Sensing Mutants of Staphylococcus epidermidis In Vivo
Open accessAbstract
Infections with the leading nosocomial pathogen Staphylococcus epidermidis are characterized by biofilm development on indwelling medical devices. We demonstrate that the quorum-sensing regulator agr affects the biofilm development of S. epidermidis in an unexpected fashion and is likely involved in promoting biofilm detachment. An isogenic agr mutant showed increased biofilm development and colonization in a rabbit model. In addition, nonfunctional agr occurred more frequently among strains isolated from infections of joint prostheses. Lack of functionality was based on mutations, including insertion of an IS256 element. Relative to other bacterial pathogens, quorum sensing in S. epidermidis thus has a different role during biofilm development and biofilm-associated infection. Our results indicate that disabling agr likely enhances the success of S. epidermidis during infection of indwelling medical devices. The permanent elimination of quorum-sensing regulation used by S. epidermidis represents a surprising and unusual means to adapt to a certain environment and type of infection.
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Cites
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The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
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MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES
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Fruiting body formation by Bacillus subtilis
Branda, S. S., González-Pastor, J. E., Ben-Yehuda, S., Losick, R., & Kolter, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191384198 · Cited by 1,129
Cited by
Coagulase-Negative Staphylococci
Becker, K., Heilmann, C., & Peters, G. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-13 · Cited by 1,628
Vuong, C., Kocianova, S., Voyich, J. M., Yao, Y., Fischer, E. R., DeLeo, F. R., & Otto, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411374200 · Cited by 592
Self-citationQuorum-sensing regulation in staphylococci—an overview
Le, K. Y., & Otto, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01174 · Cited by 490
Self-citationPeptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Molecular Basis of In Vivo Biofilm Formation by Bacterial Pathogens
Joo, H.-S., & Otto, M. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.10.022 · Cited by 434
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Metadata
- Authors
- Vuong, C., Kocianova, S., Yao, Y., Carmody, A. B., & Otto, M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-10-15
- Volume
- 190
- Issue
- 8
- Pages
- 1498-1505
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2127599536
- Cited by
- 216
- References
- 4
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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