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Cited by 459Antibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and Resistance

Comparison of Mortality Associated with Vancomycin-Resistant and Vancomycin-Susceptible Enterococcal Bloodstream Infections: A Meta-analysis

DiazGranados, C. A., Zimmer, S. M., Mitchel, K., Jernigan, J. A.·2005·Clinical Infectious Diseases
DOI 10.1086/430909
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Abstract

BACKGROUND: Whether vancomycin resistance is independently associated with mortality among patients with enterococcal bloodstream infection (BSI) is controversial. To address this issue, we performed a systematic literature review with meta-analysis. METHODS: Data sources were studies identified using the MEDLINE database (for articles from 1988 through March 2003), the Cochrane Library (for articles published up to March 2003), and bibliographies of identified articles. Inclusion criteria were that the study assessed mortality after enterococcal BSI, compared mortality after vancomycin-resistant enterococci (VRE) BSI with that after vancomycin-susceptible enterococci (VSE) BSI, and adjusted for severity of illness. Study exclusion criteria were as follows: no report of the adjusted measure of effect (adjusted odds ratio [OR], adjusted hazard ratio, or adjusted relative risk) of vancomycin resistance on mortality available and/or its adjusted 95% confidence interval (95% CI). Data in the tables, figures, or text were independently extracted by 2 of the authors. Individual weights were calculated using the 95% CI of the adjusted measures of effect performing both fixed-effect and random-effects models. RESULTS: Nine studies were eligible (11 studies met the inclusion criteria, and 2 were excluded), with a total of 1614 enterococcal BSI episodes (683 VRE episodes and 931 VSE episodes). Patients with bacteremia caused by VRE were more likely to die than were those with VSE bacteremia (summary OR, 2.52; 95% CI, 1.9-3.4). CONCLUSIONS: Vancomycin resistance is independently associated with increased mortality among patients with enterococcal bloodstream infection.

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Crossref · 10.1086/430909

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  • Infections caused by multidrug-resistant organisms carry an economic burden estimated at over 20 billion dollars per year in the US alone.

    “Infections caused by multidrug-resistant (MDR) organisms are associated with increased mortality compared to those caused by susceptible bacteria and they carry an important economic burden, estimated at over 20 billion dollars per year in the US only (2,3,4).”

    From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [3]

  • Infections caused by multidrug-resistant organisms are associated with increased mortality compared to those caused by susceptible bacteria.

    “Infections caused by multidrug-resistant (MDR) organisms are associated with increased mortality compared to those caused by susceptible bacteria and they carry an important economic burden, estimated at over 20 billion dollars per year in the US only (2,3,4).”

    From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [3]

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Authors
DiazGranados, C. A., Zimmer, S. M., Mitchel, K., & Jernigan, J. A.
Affiliations
Emory University (US)
Corresponding author
DiazGranados, C. A.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2005-08-01
Volume
41
Issue
3
Pages
327-333
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/430909
OpenAlex
W2156508440
Semantic Scholar
d34d8d59db8606201dec68c09f8818d4ce8cd6c5
Cited by
459
References
49
Citations by year
2026: 6 · 2025: 15 · 2024: 10 · 2023: 24 · 2022: 21 · 2021: 18 · 2020: 25 · 2019: 33 · 2018: 29 · 2017: 21 · 2016: 32 · 2015: 19 · 2014: 31 · 2013: 29 · 2012: 22
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords
vancomycin-resistant enterococci, vancomycin-susceptible enterococci, bacteremia, mortality, antimicrobial resistance, disease severity
MeSH terms
Humans, Odds Ratio, Bacteremia, Gram-Positive Bacterial Infections, Enterococcus, Vancomycin Resistance

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