Automatic Digital Analysis of Chromogenic Media for Vancomycin-Resistant-Enterococcus Screens Using Copan WASPLab
Open accessAbstract
Vancomycin-resistant enterococci (VRE) are an important cause of health care-acquired infections (HAIs). Studies have shown that active surveillance of high-risk patients for VRE colonization can aid in reducing HAIs; however, these screens generate a significant cost to the laboratory and health care system. Digital imaging capable of differentiating negative and "nonnegative" chromogenic agar can reduce the labor cost of these screens and potentially improve patient care. In this study, we evaluated the performance of the WASPLab Chromogenic Detection Module (CDM) (Copan, Brescia, Italy) software to analyze VRE chromogenic agar and compared the results to technologist plate reading. Specimens collected at 3 laboratories were cultured using the WASPLab CDM and plated to each site's standard-of-care chromogenic media, which included Colorex VRE (BioMed Diagnostics, White City, OR) or Oxoid VRE (Oxoid, Basingstoke, United Kingdom). Digital images were scored using the CDM software after 24 or 40 h of growth, and all manual reading was performed using digital images on a high-definition (HD) monitor. In total, 104,730 specimens were enrolled and automation agreed with manual analysis for 90.1% of all specimens tested, with sensitivity and specificity of 100% and 89.5%, respectively. Automation results were discordant for 10,348 specimens, and all discordant images were reviewed by a laboratory supervisor or director. After a second review, 499 specimens were identified as repre…
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- Authors
- Faron, M. L., Buchan, B. W., Coon, C., Liebregts, T., van Bree, A., Jansz, A. R., Soucy, G., Korver, J., & Ledeboer, N. A.
- Affiliations
- Medical College of Wisconsin (US)
- PAMM (NL)
- PAMM Laboratory of Medical Microbiology, Veldhoven, Netherlands
- CHU de Québec-Université Laval (CA)
- Hamilton Regional Laboratory Medicine Program (CA)
- ORCID
- Buchan, Blake W.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2016-10
- Volume
- 54
- Issue
- 10
- Pages
- 2464-2469
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC5035414
- OpenAlex
- W2460503493
- Cited by
- 63
- References
- 26
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 4 · 2021: 3 · 2020: 12 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- vancomycin-resistant enterococci, VRE screening, chromogenic agar, digital image analysis, active surveillance, health care-acquired infections, false-negative results
- MeSH terms
- Bacteriological Techniques, Chromogenic Compounds, Culture Media, Diagnostic Errors, Humans, Image Processing, Computer-Assisted, Mass Screening, Sensitivity and Specificity, Gram-Positive Bacterial Infections, Automation, Laboratory, Optical Imaging, Vancomycin-Resistant Enterococci
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