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Cited by 157Sepsis Diagnosis and TreatmentNeonatal and Maternal InfectionsStreptococcal Infections and Treatments

Epidemiology of Sepsis: Race, Sex, and Chronic Alcohol Abuse

Moss, Marc·2005·Clinical Infectious Diseases
DOI 10.1086/432003
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Abstract

The annual incidences of severe sepsis in several industrialized nations have recently been reported to be 50-100 cases per 100,000 persons. These numbers exceed the estimated rates for other diseases that hold a heightened public awareness, including breast cancer and acquired immune deficiency syndrome. There are also sex and race differences in the incidence of sepsis. Men are more likely than women to develop sepsis, with a mean annual relative risk of 1.28. Nonwhites are nearly twice as likely to develop sepsis as whites. These race and sex disparities in the incidence of sepsis are likely explained by differences in a variety of factors, including the presence of comorbid conditions. For example, chronic alcohol abuse is associated with a persistent fever, delayed resolution of symptoms, increased rates of bacteremia, increased use of intensive care, prolonged duration of hospital stay, and increased cost of hospitalization for infected patients.

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Crossref · 10.1086/432003

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78 of 78 references verified0 citation errors · 0 not checkable

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  • Alcohol exposure has a suppressive effect on the release of cytokines responsible for cell signalling and critical for regulation of host defence.

    “Alcohol exposure has a suppressive effect on the release of cytokines responsible for cell signalling and critical for regulation of the host defence 80, 81.”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [80]

  • Chronic alcohol exposure specifically impairs the immune defences and functioning of the lower respiratory tract, increasing the risk of both viral and bacterial pneumonia.

    “Apart from the general immunosuppressive effects explained above, chronic alcohol exposure specifically impairs the immune defences and functioning of the lower respiratory tract, increasing the risk of both viral and bacterial pneumonia.”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [80]

  • Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, especially with heavy drinking and alcohol use disorders.

    “Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, and especially with heavy drinking and alcohol use disorders 79, 80, 81, 214, 215, 216, 217.”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [80]

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Authors
Moss, M.
Affiliations
Emory University (US)
Corresponding author
Moss, Marc
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2005-11-15
Volume
41
Issue
Supplement_7
Pages
S490-S497
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/432003
OpenAlex
W2133641948
Cited by
157
References
78
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 13 · 2013: 8 · 2012: 9
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (AA-013757, AA-014435, R01AA014435, P50AA013757)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
Keywords
sepsis, racial disparities, sex differences, chronic alcohol abuse, comorbidities, bacteremia, intensive care utilization, length of hospital stay, hospital costs, persistent fever
MeSH terms
Alcoholism, Animals, Cross Infection, England, France, Humans, Intensive Care Units, Length of Stay, Prognosis, Respiratory Distress Syndrome, Risk Factors, Sex Factors, United States, Comorbidity, Incidence, Sepsis

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